The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Estimation of glomerular filtration rates before and after orthotopic liver transplantation: Evaluation of current equations
Abstract
The ability to estimate rather than measure the glomerular filtration rate (GFR) in patients before and after liver transplantation would be helpful in estimating risk, dosing drugs, and assessing long-term toxicity of calcineurin inhibitors. Currently available equations for estimating the GFR have not been validated in either the pre- or post-liver transplant population. We have evaluated the performance of currently used formulas for the estimation of the GFR in this setting. Data were collected prospectively on patients who underwent liver transplantation between 1984 and 2001. GFR per 1.73 m 2 was measured by I 125 iothalamate in patients at the pretransplant evaluation and at 3 months, 1 year, and yearly posttransplant thereafter. GFR estimated by the Cockcroft-Gault equation, the Nankivell equation, and the equations from the Modification of Diet in Renal Disease (MDRD) Study (6, 5, and 4 variables) was compared with the measured GFR. Pretransplant GFR was available in 1,447 patients. The mean GFR was 90.7 ± 40.5 mL/min. Values for r and r 2 were highest for the MDRD Study 6-variable equation (0.70 and 0.49, respectively). Only 66% of estimates were within 30% of the measured GFR. At 3 months, 1 year, and 5 years posttransplant, the mean GFR was 59.5 ± 27.1 mL/min, 62.7 ± 27.8 mL/min, and 55.3 ± 26.1 mL/min, respectively. Values for r and r 2 for the MDRD Study 6-variable equations at 1 and 5 years posttransplant were 0.74 (0.55) and 0.76 (0.58), respectively. At these time points, however, only 67% and 64% of the estimated GFR were within 30% of the measured GFR. MDRD Study equations had greater precision than other equations, but the precision was lower than reported for MDRD estimation of GFR in other populations. Better methods for estimating the GFR are required for evaluation of renal function before and after liver transplantation. (Liver Transpl 2004;10:301-309.)
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Cites
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Self-citationA Model to Predict Survival in Patients With End–Stage Liver Disease
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Carreras, L., Poveda, R., Bas, J., Mestre, M., Rama, I., & Carrera, M. (2002) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2002.32799 · Cited by 1,474
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A New Equation to Estimate Glomerular Filtration Rate
Levey, A. S., Stevens, L. A., Schmid, C. H., Zhang, Y. (., Castro, A. F., Feldman, H. I., Kusek, J. W., Eggers, P., Van Lente, F., Greene, T., et al. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-9-200905050-00006 · Cited by 25,603
Self-citationAssessing Kidney Function — Measured and Estimated Glomerular Filtration Rate
Stevens, L. A., Coresh, J., Greene, T., & Levey, A. S. (2006) · New England Journal of Medicine · doi:10.1056/nejmra054415 · Cited by 2,952
Self-citationGinès, P., & Schrier, R. W. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0809139 · Cited by 837
Stevens, L. A., Schmid, C. H., Greene, T., Zhang, Y. (., Beck, G. J., Froissart, M., Hamm, L. L., Lewis, J. B., Mauer, M., Navis, G. J., et al. (2010) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2010.03.026 · Cited by 600
Self-citationWong, F., Nadim, M. K., Kellum, J. A., Salerno, F., Bellomo, R., Gerbes, A., Angeli, P., Moreau, R., Davenport, A., Jalan, R., et al. (2011) · Gut · doi:10.1136/gut.2010.236133 · Cited by 414
Metadata
- Authors
- Gonwa, T. A., Jennings, L., Mai, M. L., Stark, P. C., Levey, A. S., & Klintmalm, G. B.
- Venue
- Liver Transplantation
- Published
- 2004-02
- Volume
- 10
- Issue
- 2
- Pages
- 301-309
- ISSN
- 1527-6465 (ISSN-L)
- OpenAlex
- W2068718128
- Cited by
- 313
- References
- 22
- FWCI
- 9.39
- Type
- journal article
- Language
- en
- Open access
- closed
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