Iron overload and unique susceptibility of liver transplant recipients to disseminated disease due to opportunistic pathogens.
Open accessAbstract
The propensity of liver transplant recipients to develop more fulminant disease presentation and a higher risk of disseminated disease due to a number of opportunistic infections, including invasive aspergillosis, cryptococcosis, zygomycosis, may be related to iron overload. Abnormalities in iron homeostasis may also be a contributor to severe manifestations due to other pathogens such as cytomegalovirus and Staphylococcus aureus in liver transplant recipients. Iron is essential not only for microbial pathogenesis, but directly impairs pivotal pathogen specific host defenses. Studies to assess iron homeostasis and the mechanisms by which iron overload contributes to the pathogenesis of opportunistic infections in liver transplant recipients are warranted.
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Fe overload is an independent risk factor for post-transplant infection.
“clinical evidence also indicates that Fe overload is an independent risk factor for post-transplant infection [20], [21]”
From Host Iron Withholding Demands Siderophore Utilization for Candida glabrata to Survive Macrophage Killing (2011) · cites this paper as [20]
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Self-citation
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Self-citationRisk stratification for invasive aspergillosis in immunocompromised patients
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“independent risk factor for post-transplant infection [20,21] and”
BackgroundUnrecognized Pretransplant and Donor‐Derived Cryptococcal Disease in Organ Transplant Recipients
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Rodríguez‐Rodríguez, S., Olivas‐Martínez, A., la Mora, J. D.-D., Martínez‐Benítez, B., García‐Juárez, I., & Demichelis‐Gómez, R. (2024) · Revista de investigaci�n Cl�nica · doi:10.24875/ric.23000246
- Authors
- Singh, N., & Sun, H.-Y.
- Affiliations
- National Taiwan University (TW)
- Corresponding author
- Singh, Nina
- ORCID
- Sun, Hsin-Yun
- Venue
- Liver Transplantation
- Published
- 2008-09
- Volume
- 14
- Issue
- 9
- Pages
- 1249-1255
- ISSN
- 1527-6465 (ISSN-L)
- OpenAlex
- W2066766815
- Cited by
- 40
- References
- 99
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 3 · 2014: 2 · 2013: 6 · 2012: 4
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Liver Transplantation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Keywords
- iron overload, iron homeostasis, liver transplant recipients, opportunistic infections, disseminated fungal infection, invasive aspergillosis, cryptococcosis, mucormycosis, cytomegalovirus, Staphylococcus aureus, host defense impairment
- MeSH terms
- Aspergillosis, Cryptococcosis, Cryptococcus, Cytomegalovirus, T-Lymphocytes, Helper-Inducer, Homeostasis, Humans, Iron, Opportunistic Infections, Staphylococcus aureus, Liver Transplantation, Hepacivirus, Simplexvirus, Iron Overload, Zygomycosis
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