Cited by 40Iron Metabolism and DisordersOrgan Transplantation Techniques and OutcomesAntifungal resistance and susceptibility

Iron overload and unique susceptibility of liver transplant recipients to disseminated disease due to opportunistic pathogens.

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Singh, Nina, Sun, Hsin-Yun·2008·Liver Transplantation

Abstract

The propensity of liver transplant recipients to develop more fulminant disease presentation and a higher risk of disseminated disease due to a number of opportunistic infections, including invasive aspergillosis, cryptococcosis, zygomycosis, may be related to iron overload. Abnormalities in iron homeostasis may also be a contributor to severe manifestations due to other pathogens such as cytomegalovirus and Staphylococcus aureus in liver transplant recipients. Iron is essential not only for microbial pathogenesis, but directly impairs pivotal pathogen specific host defenses. Studies to assess iron homeostasis and the mechanisms by which iron overload contributes to the pathogenesis of opportunistic infections in liver transplant recipients are warranted.

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Authors
Singh, N., & Sun, H.-Y.
Affiliations
National Taiwan University (TW)
Corresponding author
Singh, Nina
Venue
Liver Transplantation
Published
2008-09
Volume
14
Issue
9
Pages
1249-1255
ISSN
1527-6465 (ISSN-L)
OpenAlex
W2066766815
Cited by
40
References
99
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 3 · 2014: 2 · 2013: 6 · 2012: 4
FWCI
0.31
Type
journal article
Language
en
Open access
Locations
  • Liver Transplantation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Keywords
iron overload, iron homeostasis, liver transplant recipients, opportunistic infections, disseminated fungal infection, invasive aspergillosis, cryptococcosis, mucormycosis, cytomegalovirus, Staphylococcus aureus, host defense impairment
MeSH terms
Aspergillosis, Cryptococcosis, Cryptococcus, Cytomegalovirus, T-Lymphocytes, Helper-Inducer, Homeostasis, Humans, Iron, Opportunistic Infections, Staphylococcus aureus, Liver Transplantation, Hepacivirus, Simplexvirus, Iron Overload, Zygomycosis

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