Functionalized synthetic biodegradable polymer scaffolds for tissue engineering.
Open accessAbstract
Scaffolds (artificial ECMs) play a pivotal role in the process of regenerating tissues in 3D. Biodegradable synthetic polymers are the most widely used scaffolding materials. However, synthetic polymers usually lack the biological cues found in the natural extracellular matrix. Significant efforts have been made to synthesize biodegradable polymers with functional groups that are used to couple bioactive agents. Presenting bioactive agents on scaffolding surfaces is the most efficient way to elicit desired cell/material interactions. This paper reviews recent advancements in the development of functionalized biodegradable polymer scaffolds for tissue engineering, emphasizing the syntheses of functional biodegradable polymers, and surface modification of polymeric scaffolds.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some synthetic biodegradable polymers have attracted considerable attention because they present high biocompatibility, ease of processing, and tailored mechanical properties and degradation rates.
“some synthetic biodegradable polymers have attracted considerable attention over the past decades since the present high biocompatibility, ease of processing, as well as tailored mechanical properties and degradation rates [21][22][23][24][25][26]”
From A strategy to tailor the mechanical and degradation properties of PCL-PEG-PCL based copolymers for biomedical application (2023) · cites this paper as [23]
Cites
Lutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551 · see citing works
Designing materials for biology and medicine
Langer, R., & Tirrell, D. A. (2004) · Nature · doi:10.1038/nature02388 · Cited by 3,198 · see citing works
Santerre, J. P., Woodhouse, K., Laroche, G., & Labow, R. S. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.05.079 · Cited by 718 · see citing works
The nanofibrous architecture of poly(l-lactic acid)-based functional copolymers
Liu, X., & Ma, P. X. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2009.09.046 · Cited by 104 · see citing works
Self-citationGautier, S., D'Aloia, V., Halleux, O., Mazza, M., Lecomte, P., & Jérôme, R. (2003) · Journal of Biomaterials Science, Polymer Edition · doi:10.1163/15685620360511146 · Cited by 49 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Biodegradable and biocompatible polymers for tissue engineering application: A review
Asghari, F., Samiei, M., Adibkia, K., Akbarzadeh, A., & Davaran, S. (2017) · Artificial Cells, Nanomedicine, and Biotechnology · doi:10.3109/21691401.2016.1146731 · Cited by 482 · see citing works
Liu, Y.-Y., Blázquez, J. P. F., Yin, G.-Z., Wang, D.-Y., Llorca, J., & Echeverry-Rendón, M. (2023) · arXiv · doi:10.48550/arxiv.2308.15503 · Cited by 46 · see citing works
- Authors
- Liu, X., Holzwarth, J. M., & Ma, P. X.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Ma, Peter X.
- Venue
- Macromolecular Bioscience
- Publisher
- Wiley
- Published
- 2012-03-06
- Volume
- 12
- Issue
- 7
- Pages
- 911-919
- ISSN
- 1616-5187 (ISSN-L)
- 1616-5195
- OpenAlex
- W2139033684
- Cited by
- 290
- References
- 5
- Citations by year
- 2026: 3 · 2025: 21 · 2024: 12 · 2023: 20 · 2022: 23 · 2021: 24 · 2020: 20 · 2019: 25 · 2018: 25 · 2017: 24 · 2016: 24 · 2015: 21 · 2014: 21 · 2013: 22 · 2012: 5
- FWCI
- 1.14
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Macromolecular Bioscience (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- biodegradable polymers, tissue engineering, extracellular matrix mimics, functionalized polymers, surface modification, cell-material interactions, polymer synthesis
- MeSH terms
- Polylactic Acid-Polyglycolic Acid Copolymer, Apatites, Carboxylic Acids, Cells, Cultured, Extracellular Matrix, Gelatin, Humans, Microscopy, Electron, Scanning, Phosphates, Polyglycolic Acid, Surface Properties, Biomarkers, Gene Expression, Lactic Acid, Tissue Engineering, Biomimetic Materials, Chitosan
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
