A Near-Infrared Photothermal Effect-Responsive Drug Delivery System Based on Indocyanine Green and Doxorubicin-Loaded Polymeric Micelles Mediated by Reversible Diels–Alder Reaction
Abstract
Near-infrared light (NIR) possesses great advantages for light-responsive controllable drug release, such as deep tissue penetration and low damage to healthy tissues. Herein, a NIR-responsive drug delivery system is developed based on a NIR dye, indocyanine green (ICG), and anticancer drug, doxorubicin (DOX)-loaded thermoresponsive block copolymer micelles, in which the drug release can be controlled via NIR irradiation. First, block copolymers, poly(oligo(ethylene glycol) methacrylate)-block-poly(furfuryl methacrylate) (POEGMA-b-PFMA), are synthesized by sequential reversible addition-fragmentation chain-transfer (RAFT) polymerization, followed by modification with N-octyl maleimide through Diels-Alder (DA) reaction to produce POEGMA-b-POMFMA. The self-assembly of POEGMA-b-POMFMA by nano-precipitation in aqueous solution affords the polymeric micelles which are used to simultaneously encapsulate ICG and DOX. Upon irradiation by NIR light (805 nm), the loaded DOX is released rapidly from the micelles due to partial retro DA reaction and local temperature increase-induced faster drug diffusion by the photothermal effect. Cytotoxicity evaluation and intracellular distribution observation demonstrate significant synergistic effects of NIR-triggered drug release, photothermal, and chemotherapy toward cancer cells under NIR irradiation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The photothermal effect resulted from 805 nm-NIR irradiation of ICG located in the internal side of micelles caused an increase in temperature in the micellar core, which led to accelerated release of DOX.
“the photothermal effect resulted from 805 nm-NIR irradiation of ICG, which is located in the internal side of micelles caused an increase in temperature in the micellar core. This, in turn, led to the accelerated release of DOX.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [185]
Li and coworkers developed block copolymer nanomicelles consisting of poly(oligo(ethylene glycol)methacrylate)-block-poly(furfuryl methacrylate) (POEGMA-b-PFMA) that possessed thermosensitive properties and could deliver drug molecules according to NIR response.
“Another approach was developed by Li and coworkers whereby block copolymer nanomicelles consisting of poly(oligo(ethylene glycol)methacrylate)-block-poly(furfuryl methacrylate) (POEGMA-b-PFMA) possessed thermosensitive properties and could deliver drug molecules according to NIR response [185].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [185]
PNMs bearing NIR dye indocyanine green (ICG) and DOX could efficiently and selectively deliver the drug to the targeted site.
“Such PNMs bearing NIR dye indocyanine green (ICG) and DOX could efficiently and selectively deliver the drug to the targeted site.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [185]
Cites
Nanocarriers as an emerging platform for cancer therapy
Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710 · see citing works
Stimuli-responsive nanocarriers for drug delivery
Mura, S., Nicolas, J., & Couvreur, P. (2013) · Nature Materials · doi:10.1038/nmat3776 · Cited by 6,289 · see citing works
A clearer vision for in vivo imaging
Weissleder, R. (2001) · Nature Biotechnology · doi:10.1038/86684 · Cited by 3,839 · see citing works
Ultrasmall Reduced Graphene Oxide with High Near-Infrared Absorbance for Photothermal Therapy
Robinson, J. T., Tabakman, S. M., Liang, Y., Wang, H., Casalongue, H. S., Vinh, D., & Dai, H. (2011) · Journal of the American Chemical Society · doi:10.1021/ja2010175 · Cited by 2,099 · see citing works
Gold Nanorods: From Synthesis and Properties to Biological and Biomedical Applications
Huang, X., Neretina, S., & El‐Sayed, M. A. (2009) · Advanced Materials · doi:10.1002/adma.200802789 · Cited by 1,923 · see citing works
Targeted polymeric therapeutic nanoparticles: design, development and clinical translation
Kamaly, N., Xiao, Z., Valencia, P. M., Radovic‐Moreno, A. F., & Farokhzad, O. C. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15344k · Cited by 1,734 · see citing works
Gold nanocages covered by smart polymers for controlled release with near-infrared light
Yavuz, M. S., Cheng, Y., Chen, J., Cobley, C. M., Zhang, Q., Rycenga, M., Xie, J., Kim, C., Song, K. H., Schwartz, A. G., et al. (2009) · Nature Materials · doi:10.1038/nmat2564 · Cited by 1,404 · see citing works
Ge, Z., & Liu, S. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60048c · Cited by 917 · see citing works
Self-citationIn Vivo Near-Infrared Mediated Tumor Destruction by Photothermal Effect of Carbon Nanotubes
Moon, H. K., Lee, S. H., & Choi, H. C. (2009) · ACS Nano · doi:10.1021/nn900904h · Cited by 796 · see citing works
Sheng, Z., Hu, D., Zheng, M., Zhao, P., Liu, H., Gao, D., Gong, P., Gao, G., Zhang, P., Ma, Y., et al. (2014) · ACS Nano · doi:10.1021/nn5062386 · Cited by 719 · see citing works
Zhang, Z., Wang, J., Nie, X., Wen, T., Ji, Y., Wu, X., Zhao, Y., & Chen, C. (2014) · Journal of the American Chemical Society · doi:10.1021/ja412735p · Cited by 637 · see citing works
Remotely Triggerable Drug Delivery Systems
Timko, B. P., Dvir, T., & Kohane, D. S. (2010) · Advanced Materials · doi:10.1002/adma.201002072 · Cited by 613 · see citing works
Photo-responsive block copolymer micelles: design and behavior
Gohy, J., & Zhao, Y. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35469e · Cited by 533 · see citing works
Cancer Theranostics with Near-Infrared Light-Activatable Multimodal Nanoparticles
Melancon, M. P., Zhou, M., & Li, C. (2011) · Accounts of Chemical Research · doi:10.1021/ar200022e · Cited by 501 · see citing works
Photochemical mechanisms of light-triggered release from nanocarriers
Fomina, N., Sankaranarayanan, J., & Almutairi, A. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.02.006 · Cited by 491 · see citing works
Yan, B., Boyer, J., Branda, N. R., & Zhao, Y. (2011) · Journal of the American Chemical Society · doi:10.1021/ja209793b · Cited by 455 · see citing works
Yu, J. Z., Javier, D. J., Yaseen, M. A., Nitin, N., Richards-Kortum, R. R., Anvari, B., & Wong, M. S. (2010) · Journal of the American Chemical Society · doi:10.1021/ja908139y · Cited by 310 · see citing works
Supramolecular Nanodevices: From Design Validation to Theranostic Nanomedicine
Cabral, H., Nishiyama, N., & Kataoka, K. (2011) · Accounts of Chemical Research · doi:10.1021/ar200094a · Cited by 290 · see citing works
König, K., Becker, T., Fischer, P., Riemann, I., & Halbhuber, K. J. (1999) · Optics Letters · doi:10.1364/ol.24.000113 · Cited by 259 · see citing works
Dual imaging-guided photothermal/photodynamic therapy using micelles
Guo, M., Mao, H., Li, Y., Zhu, A., He, H., Yang, H., Wang, Y., Tian, X., Ge, C., Peng, Q., et al. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.02.018 · Cited by 234 · see citing works
Anionic Polyelectrolyte-Stabilized Nanoparticles via RAFT Aqueous Dispersion Polymerization
Semsarilar, M., Ladmiral, V., Blanazs, A., et al. (2011) · Langmuir · doi:10.1021/la203991y · Cited by 210 · see citing works
Room-Temperature Healing of a Thermosetting Polymer Using the Diels−Alder Reaction
Peterson, A. M., Jensen, R. E., & Palmese, G. R. (2010) · ACS Applied Materials & Interfaces · doi:10.1021/am9009378 · Cited by 203 · see citing works
Smart chemistry in polymeric nanomedicine
Tong, R., Tang, L., Ma, L., Tu, C., Baumgartner, R., & Cheng, J. (2014) · Chemical Society Reviews · doi:10.1039/c4cs00133h · Cited by 191 · see citing works
Wei, Q., Ji, J., & Shen, J. (2008) · Macromolecular Rapid Communications · doi:10.1002/marc.200800009 · Cited by 144 · see citing works
Bakhtiari, A. B. S., Hsiao, D., Jin, G., et al. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200805303 · Cited by 139 · see citing works
Photodegradable Polymers for Biotechnological Applications
Pasparakis, G., Manouras, T., Argitis, P., & Vamvakaki, M. (2011) · Macromolecular Rapid Communications · doi:10.1002/marc.201100637 · Cited by 124 · see citing works
Wan, Z., Mao, H., Guo, M., Li, Y., Zhu, A., Yang, H., He, H., Shen, J., Zhou, L., Jiang, Z., et al. (2014) · Theranostics · doi:10.7150/thno.8171 · Cited by 112 · see citing works
Ge, Z., Luo, S., & Liu, S. (2006) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.21261 · Cited by 98 · see citing works
Self-citationSun, H. R., Kabb, C. P., & Sumerlin, B. S. (2014) · Chemical Science · doi:10.1039/c4sc02290d · Cited by 82 · see citing works
A Deep, Water‐Soluble Cavitand Acts as a Phase‐Transfer Catalyst for Hydrophobic Species
Hooley, R. J., Biros, S. M., & REBEK, J. J. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200600405 · Cited by 71 · see citing works
Yamashita, S., Fukushima, H., Niidome, Y., Mori, T., Katayama, Y., & Niidome, T. (2011) · Langmuir · doi:10.1021/la2036746 · Cited by 71 · see citing works
Near-infrared light-triggered drug release nanogels for combined photothermal-chemotherapy of cancer
Zan, M., Li, J., Huang, M., Lin, S., Luo, D., Luo, S., & Ge, Z. (2015) · Biomaterials Science · doi:10.1039/c5bm00048c · Cited by 68 · see citing works
Self-citationReversible releasing of arms from star morphology polymers
Aumsuwan, N., & Urban, M. W. (2008) · Polymer · doi:10.1016/j.polymer.2008.10.048 · Cited by 33 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Recent Advances in Nanomicelles Delivery Systems.
Tawfik, S. M., Azizov, S., Elmasry, M. R., Sharipov, M., & Lee, Y.-I. (2020) · Nanomaterials · doi:10.3390/nano11010070 · Cited by 156 · see citing works
“Another approach was developed by Li and coworkers whereby block copolymer nanomicelles consisting of poly(oligo(ethylene glycol)methacrylate)-block-poly(furfuryl methacrylate) (POEGMA-b-PFMA) possessed thermosensitive properties and could deliver drug molecules according to NIR response [185].”
Background
- Authors
- Li, H., Li, J., Ke, W., & Ge, Z.
- Affiliations
- University of Science and Technology of China (CN)
- Corresponding author
- Ge, Zhishen
- Venue
- Macromolecular Rapid Communications
- Publisher
- Wiley
- Published
- 2015-08-14
- Volume
- 36
- Issue
- 20
- Pages
- 1841-1849
- ISSN
- 1022-1336 (ISSN-L)
- 1521-3927
- OpenAlex
- W1505190116
- Cited by
- 47
- References
- 33
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 1 · 2021: 6 · 2020: 4 · 2019: 2 · 2018: 6 · 2017: 13 · 2016: 5
- FWCI
- 3.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Macromolecular Rapid Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Scientific Foundation of China (51273188, 81201176)
- Foundation for the Author of National Excellent Doctoral Dissertation (201224)
- Central Universities (WK2060200012)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Keywords
- near-infrared photothermal effect, drug delivery systems, indocyanine green, doxorubicin, polymeric micelles, thermoresponsive block copolymers, RAFT polymerization, photothermal drug release, cancer cells
- MeSH terms
- Antineoplastic Agents, Cell Survival, Chemistry, Pharmaceutical, Doxorubicin, Drug Screening Assays, Antitumor, HeLa Cells, Humans, Infrared Rays, Micelles, Molecular Weight, Particle Size, Polyethylene Glycols, Polymethacrylic Acids, Temperature, Photochemical Processes, Polymerization, Cycloaddition Reaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
