Controlled-Release System of Small Molecules Triggered by the Photothermal Effect of Polypyrrole
Abstract
In this paper, a novel synthesis of polyethylene glycol (PEG)-modified polypyrrole (PPy) nanomaterials is demonstrated by combining reversible addition-fragmentation chain transfer polymerization and oxidative polymerization. Dye molecules with a heat-labile linker are used as a model drug and covalently anchored onto the PEGlated PPy nanomaterials via "click chemistry." The strong absorption of such PPy nanomaterials in the near-infrared region endows the system excellent photothermal effect, which can be used not only as efficient photothermal agents for photothermal therapy but also good controllers of a drug-release system by retro D-A reaction.
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The novel product of modification of polypyrrole with PEG and pyrene-oxabicycleheptenealkyne (POA) was designed to link covalently hydrophobic anticancer therapeutic units.
“the novel product of modification of polypyrrole with PEG and pyrene-oxabicycleheptenealkyne (POA) was designed recently to link covalently hydrophobic anticancer therapeutic units [184].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [184]
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Recent Advances in Nanomicelles Delivery Systems.
Tawfik, S. M., Azizov, S., Elmasry, M. R., Sharipov, M., & Lee, Y.-I. (2020) · Nanomaterials · doi:10.3390/nano11010070 · Cited by 156 · see citing works
“In addition, the novel product of modification of polypyrrole with PEG and pyrene-oxabicycleheptenealkyne (POA) was designed recently to link covalently hydrophobic anticancer therapeutic units [184].”
Background
- Authors
- Zhang, H., Xiong, L., Liao, X., & Huang, K.
- Affiliations
- East China Normal University (CN)
- Fudan University (CN)
- Corresponding author
- Liao, Xiaojuan
- Huang, Kun
- Venue
- Macromolecular Rapid Communications
- Publisher
- Wiley
- Published
- 2015-11-02
- Volume
- 37
- Issue
- 2
- Pages
- 149-154
- ISSN
- 1022-1336 (ISSN-L)
- 1521-3927
- OpenAlex
- W1915621409
- Cited by
- 25
- References
- 45
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 4
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Macromolecular Rapid Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (51273066, 21574042, 21204022)
- Shanghai Pujiang Program (13PJ1402300)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Polymers and Plastics › Conducting polymers and applications
- Keywords
- controlled drug release, photothermal effect, photothermal therapy, polyethylene glycol modification, near-infrared absorption, dye molecules, click chemistry, retro-Diels-Alder reaction, RAFT polymerization, oxidative polymerization
- MeSH terms
- Delayed-Action Preparations, Fluorescent Dyes, Gold, Infrared Rays, Polyethylene Glycols, Polymers, Pyrenes, Pyrroles, Microscopy, Electron, Transmission, Nanoparticles, Photochemical Processes, Click Chemistry, Drug Liberation
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