Cited by 25Nanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryConducting polymers and applications

Controlled-Release System of Small Molecules Triggered by the Photothermal Effect of Polypyrrole

Zhang, Hui, Xiong, Linfeng, Liao, Xiaojuan, Huang, Kun·2016·Macromolecular Rapid Communications

Abstract

In this paper, a novel synthesis of polyethylene glycol (PEG)-modified polypyrrole (PPy) nanomaterials is demonstrated by combining reversible addition-fragmentation chain transfer polymerization and oxidative polymerization. Dye molecules with a heat-labile linker are used as a model drug and covalently anchored onto the PEGlated PPy nanomaterials via "click chemistry." The strong absorption of such PPy nanomaterials in the near-infrared region endows the system excellent photothermal effect, which can be used not only as efficient photothermal agents for photothermal therapy but also good controllers of a drug-release system by retro D-A reaction.

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Crossref · 10.1002/marc.201500523

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45 of 45 references verified0 citation errors · 0 not checkable

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  • The novel product of modification of polypyrrole with PEG and pyrene-oxabicycleheptenealkyne (POA) was designed to link covalently hydrophobic anticancer therapeutic units.

    “the novel product of modification of polypyrrole with PEG and pyrene-oxabicycleheptenealkyne (POA) was designed recently to link covalently hydrophobic anticancer therapeutic units [184].”

    From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [184]

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Authors
Zhang, H., Xiong, L., Liao, X., & Huang, K.
Affiliations
  • East China Normal University (CN)
  • Fudan University (CN)
Corresponding author
  • Liao, Xiaojuan
  • Huang, Kun
Venue
Macromolecular Rapid Communications
Publisher
Wiley
Published
2015-11-02
Volume
37
Issue
2
Pages
149-154
ISSN
  • 1022-1336 (ISSN-L)
  • 1521-3927
OpenAlex
W1915621409
Cited by
25
References
45
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 4
FWCI
1.82
Type
journal article
Language
en
Open access
closed
Locations
  • Macromolecular Rapid Communications (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (51273066, 21574042, 21204022)
  • Shanghai Pujiang Program (13PJ1402300)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Materials Science › Polymers and Plastics › Conducting polymers and applications
Keywords
controlled drug release, photothermal effect, photothermal therapy, polyethylene glycol modification, near-infrared absorption, dye molecules, click chemistry, retro-Diels-Alder reaction, RAFT polymerization, oxidative polymerization
MeSH terms
Delayed-Action Preparations, Fluorescent Dyes, Gold, Infrared Rays, Polyethylene Glycols, Polymers, Pyrenes, Pyrroles, Microscopy, Electron, Transmission, Nanoparticles, Photochemical Processes, Click Chemistry, Drug Liberation

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