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The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.

Imaging mass spectrometry

Open access
McDonnell, Liam A., Heeren, Ron M.A.·2007·Mass Spectrometry Reviews

Abstract

Imaging mass spectrometry combines the chemical specificity and parallel detection of mass spectrometry with microscopic imaging capabilities. The ability to simultaneously obtain images from all analytes detected, from atomic to macromolecular ions, allows the analyst to probe the chemical organization of a sample and to correlate this with physical features. The sensitivity of the ionization step, sample preparation, the spatial resolution, and the speed of the technique are all important parameters that affect the type of information obtained. Recently, significant progress has been made in each of these steps for both secondary ion mass spectrometry (SIMS) and matrix‐assisted laser desorption/ionization (MALDI) imaging of biological samples. Examples demonstrating localization of proteins in tumors, a reduction of lamellar phospholipids in the region binding two single celled organisms, and sub‐cellular distributions of several biomolecules have all contributed to an increasing upsurge in interest in imaging mass spectrometry. Here we review many of the instrumental developments and methodological approaches responsible for this increased interest, compare and contrast the information provided by SIMS and MALDI imaging, and discuss future possibilities. © 2007 Wiley Periodicals, Inc., Mass Spectrom. Rev.

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Metadata

Authors
McDonnell, L. A., & Heeren, R. M. A.
Venue
Mass Spectrometry Reviews
Publisher
Wiley
Published
2007-04-30
Volume
26
Issue
4
Pages
606-643
ISSN
  • 0277-7037 (ISSN-L)
  • 1098-2787
OpenAlex
W1965011257
Cited by
1,082
References
128
FWCI
31.37
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Imaging mass spectrometry. https://app.cochat.ai/papers/10.1002/mas.20124
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McDonnell, L. A., & Heeren, R. M. A. (2007). Imaging mass spectrometry. Mass Spectrometry Reviews. https://doi.org/10.1002/mas.20124

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