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Metabolomic applications of HILIC–LC–MS
Abstract
Hydrophilic interaction liquid chromatography (HILIC), although not a new technique, has enjoyed a recent renaissance with the introduction of robust and reproducible stationary phases. It is consequently finding application in metabolomics studies, which have traditionally relied on the stability of reversed phases (RPs), since the biofluids analyzed are predominantly aqueous and thus contain many polar analytes. HILIC's retention of those polar compounds and use of solvents readily compatible with mass spectrometry have seen its increasing adoption in studies of complex aqueous metabolomes. This review describes the stationary phases and their features, surveys HILIC–LC–MS's role in metabolomics experiments, discusses approaches to data extraction and analysis including multivariate analysis, and reviews the literature on HILIC–MS applications in metabolomics. © 2009 Wiley Periodicals, Inc., Mass Spec Rev 29:671–684, 2010
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A leisurely look at the bootstrap, the jackknife, and cross-validation
Efron, B., & Gong, G. (1983) · The American Statistician · doi:10.1080/00031305.1983.10483087 · Cited by 3,229
Microbial metabolomics: toward a platform with full metabolome coverage
Werf, M. J. V. D., Overkamp, K. M., Muilwijk, B., Coulier, L., & Hankemeier, T. (2007) · Analytical Biochemistry · doi:10.1016/j.ab.2007.07.022 · Cited by 207
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Integration of GC–MS and LC–MS for untargeted metabolomics profiling
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Advances in metabolite identification
Wishart, D. S. (2011) · Bioanalysis · doi:10.4155/bio.11.155 · Cited by 284
Statistical workflow for feature selection in human metabolomics data
Antonelli, J., Claggett, B. L., Henglin, M., Kim, A., Ovsak, G., Kim, N., Deng, K., Rao, K., Tyagi, O., Watrous, J. D., et al. (2019) · Metabolites · doi:10.3390/metabo9070143 · Cited by 88
Guo, B., Chen, B., Liu, A., Zhu, W., & Yao, S. (2012) · Current Drug Metabolism · doi:10.2174/138920012803341401 · Cited by 80
Metadata
- Authors
- Cubbon, S., Antonio, C., Wilson, J., & Thomas‐Oates, J.
- Venue
- Mass Spectrometry Reviews
- Publisher
- Wiley
- Published
- 2009-06-25
- Volume
- 29
- Issue
- 5
- Pages
- 671-684
- ISSN
- 0277-7037 (ISSN-L)
- 1098-2787
- OpenAlex
- W2101989062
- Cited by
- 184
- References
- 2
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- closed
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