The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Placebo‐controlled study of rTMS for the treatment of Parkinson's disease
Abstract
The objective of this study is to assess the safety and efficacy of repetitive transcranial magnetic stimulation (rTMS) for gait and bradykinesia in patients with Parkinson's disease (PD). In a double‐blind placebo‐controlled study, we evaluated the effects of 25 Hz rTMS in 18 PD patients. Eight rTMS sessions were performed over a 4‐week period. Four cortical targets (left and right motor and dorsolateral prefrontal cortex) were stimulated in each session, with 300 pulses each, 100% of motor threshold intensity. Left motor cortex (MC) excitability was assessed using motor evoked potentials (MEPs) from the abductor pollicis brevis. During the 4 weeks, times for executing walking and complex hand movements tests gradually decreased. The therapeutic rTMS effect lasted for at least 1 month after treatment ended. Right‐hand bradykinesia improvement correlated with increased MEP amplitude evoked by left MC rTMS after individual sessions, but improvement overall did not correlate with MC excitability. rTMS sessions appear to have a cumulative benefit for improving gait, as well as reducing upper limb bradykinesia in PD patients. Although short‐term benefit may be due to MC excitability enhancement, the mechanism of cumulative benefit must have another explanation. © 2005 Movement Disorder Society
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Cites
Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,483
Strafella, A. P., Paus, T., Barrett, J., & Dagher, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-15-j0003.2001 · Cited by 1,058
Zangen, A., & Hyodo, K. (2002) · NeuroReport · doi:10.1097/00001756-200212200-00005 · Cited by 145
Cited by
Rossi, S., Hallett, M., Rossini, P. M., & Pascual-Leone, A. (2009) · Clinical Neurophysiology · doi:10.1016/j.clinph.2009.08.016 · Cited by 5,367
Self-citationLefaucheur, J.-P., André-Obadia, N., Antal, A., Ayache, S. S., Baeken, C., Benninger, D. H., Cantello, R. M., Cincotta, M., de Carvalho, M., De Ridder, D., et al. (2014) · Clinical Neurophysiology · doi:10.1016/j.clinph.2014.05.021 · Cited by 2,119
Consensus: Motor cortex plasticity protocols
Ziemann, U., Paulus, W., Nitsche, M. A., Pascual-Leone, A., Byblow, W. D., Berardelli, A., Siebner, H. R., Classen, J., Cohen, L. G., & Rothwell, J. C. (2008) · Brain Stimulation · doi:10.1016/j.brs.2008.06.006 · Cited by 639
Fox, M. D., Buckner, R. L., Liu, H., Chakravarty, M. M., Lozano, A. M., & Pascual-Leone, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405003111 · Cited by 617
Metadata
- Authors
- Lomarev, M. P., Kanchana, S., Bara‐Jimenez, W., Iyer, M., Wassermann, E. M., & Hallett, M.
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2006-03
- Volume
- 21
- Issue
- 3
- Pages
- 325-331
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- OpenAlex
- W1914825850
- Cited by
- 224
- References
- 3
- FWCI
- 6.61
- Type
- journal article
- Language
- en
- Open access
- closed
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