The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Rapid eye movement sleep behavior disorder and risk of dementia in Parkinson's disease: A prospective study
Abstract
One of the most devastating nonmotor manifestations of PD is dementia. There are few established predictors of dementia in PD. In numerous cross‐sectional studies, patients with rapid eye movement (REM) sleep behavior disorder (RBD) have increased cognitive impairment on neuropsychological testing, but no prospective studies have assessed whether RBD can predict Parkinson's dementia. PD patients who were free of dementia were enrolled in a prospective follow‐up of a previously published cross‐sectional study. All patients had a polysomnogram at baseline. Over a mean 4‐year follow‐up, the incidence of dementia was assessed in those with or without RBD at baseline using regression analysis, adjusting for age, sex, disease duration, and follow‐up duration. Of 61 eligible patients, 45 (74%) were assessed and 42 were included in a full analysis. Twenty‐seven patients had baseline RBD, and 15 did not. Four years after the initial evaluation, 48% with RBD developed dementia, compared to 0% of those without (P‐adjusted = 0.014). All 13 patients who developed dementia had mild cognitive impairment on baseline examination. Baseline REM sleep atonia loss predicted development of dementia (% tonic REM = 73.2 ± 26.7 with dementia, 40.8 ± 34.5 without; P = 0.029). RBD at baseline also predicted the new development of hallucinations and cognitive fluctuations. In this prospective study, RBD was associated with increased risk of dementia. This indicates that RBD may be a marker of a relatively diffuse, complex subtype of PD. © 2012 Movement Disorder Society
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Cites
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Cited by
Visual dysfunction in Parkinson’s disease
Weil, R. S., Schrag, A. E., Warren, J. D., Crutch, S. J., Lees, A. J., & Morris, H. R. (2016) · Brain · doi:10.1093/brain/aww175 · Cited by 481
“The presence of RBD in Parkinson’s disease is also predictive of progressive cognitive dysfunction (Sinforiani et al., 2008; Postuma et al., 2012; Nomura et al., 2013).”
BackgroundParkinson’s disease dementia: a neural networks perspective
Gratwicke, J., Jahanshahi, M., & Foltynie, T. (2015) · Brain · doi:10.1093/brain/awv104 · Cited by 435
Boeve, B. F., Silber, M. H., Ferman, T. J., Lin, S. C., Benarroch, E. E., Schmeichel, A. M., Ahlskog, J. E., Caselli, R. J., Jacobson, S., Sabbagh, M., et al. (2013) · Sleep Medicine · doi:10.1016/j.sleep.2012.10.015 · Cited by 393
Minor hallucinations occur in drug‐naive Parkinson's disease patients, even from the premotor phase
Pagonabarraga, J., Martinez‐Horta, S., Fernández de Bobadilla, R., Pérez, J., Ribosa‐Nogué, R., Marín, J., Pascual‐Sedano, B., García, C., Gironell, A., & Kulisevsky, J. (2016) · Movement Disorders · doi:10.1002/mds.26432 · Cited by 236
Motor and non-motor circuit disturbances in early Parkinson disease: which happens first?
Blesa, J., Foffani, G., Dehay, B., Bezard, E., & Obeso, J. A. (2022) · Nature Reviews Neuroscience · doi:10.1038/s41583-021-00542-9 · Cited by 232
Metadata
- Authors
- Postuma, R. B., Bertrand, J., Montplaisir, J., Desjardins, C., Vendette, M., Rios Romenets, S., Panisset, M., & Gagnon, J.
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2012-02-09
- Volume
- 27
- Issue
- 6
- Pages
- 720-726
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- OpenAlex
- W2077161354
- Cited by
- 305
- References
- 39
- FWCI
- 19.63
- Type
- journal article
- Language
- en
- Open access
- closed
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