The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Gut feelings about smoking and coffee in Parkinson's disease
Open accessAbstract
Strong epidemiologic evidence suggests that smokers and coffee drinkers have a lower risk of Parkinson's disease (PD). The explanation for this finding is still unknown, and the discussion has focused on two main hypotheses. The first suggests that PD patients have premorbid personality traits associated with dislike for coffee-drinking and smoking. The second posits that caffeine and nicotine are neuroprotective. We propose an alternative third hypothesis, in which both cigarette and coffee consumption change the composition of the microbiota in the gut in a way that mitigates intestinal inflammation. This, in turn, would lead to less misfolding of the protein alpha-synuclein in enteric nerves, reducing the risk of PD by minimizing propagation of the protein aggregates to the central nervous system, where they otherwise can induce neurodegeneration.
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“Smoking reduces gut inflammation, decreases luminal epithelial permeability, and decreases the abundance of Enterobacteriaceae [189, 190].”
From The gut–brain axis in early Parkinson’s disease: from prodrome to prevention (2025) · cites this paper as [189]
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“Paradoxically, due to altered gut microbiota coffee drinkers and smokers are at a lower risk of development of this condition [432].”
From The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders (2021) · cites this paper as [432]
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Staging of brain pathology related to sporadic Parkinson’s disease
Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777
Diversity, stability and resilience of the human gut microbiota
Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K., & Knight, R. (2012) · Nature · doi:10.1038/nature11550 · Cited by 5,533
The interplay between the intestinal microbiota and the brain
Collins, S. M., Surette, M., & Bercik, P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2876 · Cited by 1,611 · cited 2×
“Interestingly, the influence of microbiota is not limited to local effects but also extends to remote organs, particularly the brain.(11,12) Several recent studies have tried to shed light on the influence of gut flora on the brain by using germ-free animals or disrupting existing microbiota, and exposing the animals…”
Braak, H., de Vos, R. A. I., Bohl, J., & Del Tredici, K. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.11.012 · Cited by 1,354
Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination
Berer, K., Mues, M., Koutrolos, M., Rasbi, Z. A., Boziki, M., Johner, C., Wekerle, H., & Krishnamoorthy, G. (2011) · Nature · doi:10.1038/nature10554 · Cited by 1,251
Epidemiology and etiology of Parkinson's disease: a review of the evidence
Wirdefeldt, K., Adami, H.-O., Cole, P., Trichopoulos, D., & Mandel, J. (2011) · European Journal of Epidemiology · doi:10.1007/s10654-011-9581-6 · Cited by 1,199
Parkinson's disease: a dual‐hit hypothesis
Hawkes, C. H., Del Tredici, K., & Braak, H. (2007) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2007.00874.x · Cited by 1,021
A meta‐analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease
Hernán, M. A., Takkouche, B., Caamaño‐Isorna, F., & Gestal‐Otero, J. J. (2002) · Annals of Neurology · doi:10.1002/ana.10277 · Cited by 818
Colonic inflammation in Parkinson's disease
Devos, D., Lebouvier, T., Lardeux, B., Biraud, M., Rouaud, T., Pouclet, H., Coron, E., Bruley des Varannes, S., Naveilhan, P., Nguyen, J.-M., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.09.007 · Cited by 627
Self-citationChen, J., Xu, K., Petzer, J. P., Staal, R. G. W., Xu, Y., Beilstein, M. A., Sonsalla, P. K., Castagnoli, K., Castagnoli, N. J., & Schwarzschild, M. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-10-j0001.2001 · Cited by 617
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A Novel Therapeutic Strategy for Parkinson's Disease based on the Gut Microbiota: A Rreview Article
Kardan, R., Nazari, M., Hemmati, J., Ahmadi, A., & Ashab, M. (2024) · Scientific Journal of Kurdistan University of Medical Sciences · doi:10.61186/sjku.29.3.11 · Cited by 1
Complex liaisons moving forward the Parkinson’s disease? An appraisal
Rubino, G. (2015) · Basal Ganglia · doi:10.1016/j.baga.2015.09.001 · Cited by 1
Involuntary Movement Disorders
Kaufman, D. M., Geyer, H. L., & Milstein, M. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-41559-0.00018-6 · Cited by 1
Does Nicotine from Passive Smoking and Foods Protect Against Parkinson’s Disease?
Faramarzi, E., Fathalizadeh, A., Sanaie, S., Mirghafourvand, M., Reyhanifard, A., Rahnemayan, S., & Mahmoodpoor, A. (2022) · Current Nutrition & Food Science · doi:10.2174/1573401318666220401112508 · Cited by 1
Ovallath, S., & Sulthana, B. (2018) · Annals of Movement Disorders · doi:10.4103/aomd.aomd_4_18 · Cited by 1
Influência do café na Doença de Parkinson
de Carvalho, L. O. R., Valério, D. G. B., da Nóbrega, H. M. G., Dantas, I. C. M., Leite, N. D. S. B., & de Sousa, M. N. A. (2019) · Revista Brasileira de Educação e Saúde · doi:10.18378/rebes.v9i2.6558 · Cited by 1
Involuntary Movement Disorders
Kaufman, D. M., Geyer, H. L., Milstein, M. J., & Rosengard, J. L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-79680-4.00018-8 · Cited by 1
Progressive models of Parkinson's disease : behavioural and neurochemical analyses
Alvarsson, A. (2015) · Figshare
Interazione caffè-microbiota intestinale: una revisione della letteratura
Condelli, S., & Savio, M. (2018) · PNEI REVIEW · doi:10.3280/pnei2018-002009
Effect of Coffee, Tobacco, and Alcohol on Parkinson’s Disease
Seol, W., Kim, H. J., & Son, I. (2021) · Journal of the Korean Neurological Association · doi:10.17340/jkna.2021.3.3
Mechanisms of development of constipation in Parkinson’s disease and therapeutic approaches
Катунина, Е. А., Shipilova, N. N., & Katunin, D. A. (2022) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202212208121
Coffee, the Metabolome and the Gut Microbiome
Favari, C., Moreno-Ortega, A., Cruz‐Carrión, Á., Rio, D. D., & Mena, P. R. (2025) · Royal Society of Chemistry eBooks · doi:10.1039/9781839166853-00153
Etude physiopathologique de la diffusion de la maladie de parkinson au système nerveux autonome
Leclair‐Visonneau, L. (2017) · theses.fr (ABES) · doi:10.70675/6537e18cze1c8z4bd8zad04z73a63a9ae4fe
Interactions foie-intestin dans la cholangite sclérosante primitive
Kemgang, A. (2019) · theses.fr (ABES) · doi:10.70675/43488c90z3a87z4265z8aeaz1b3e77ed5a3b
Metadata
- Authors
- Derkinderen, P., Shannon, K. M., & Brundin, P.
- Affiliations
- Inserm (FR)
- Rush University Medical Center (US)
- Van Andel Institute (US)
- Corresponding author
- Brundin, Patrik
- Venue
- Movement Disorders
- Publisher
- Wiley
- Published
- 2014-04-21
- Volume
- 29
- Issue
- 8
- Pages
- 976-979
- ISSN
- 0885-3185 (ISSN-L)
- 1531-8257
- PMC
- PMC4107006
- OpenAlex
- W1897759802
- Cited by
- 115
- References
- 36
- Citations by year
- 2025: 7 · 2024: 11 · 2023: 5 · 2022: 15 · 2021: 11 · 2020: 9 · 2019: 11 · 2018: 8 · 2017: 16 · 2016: 7 · 2015: 10 · 2014: 4
- FWCI
- 8.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Movement Disorders (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (U10NS044475)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Parkinson's disease, smoking, coffee consumption, gut microbiota, intestinal inflammation, enteric nerves, caffeine, nicotine, neuroprotection, premorbid personality traits, neurodegeneration
- MeSH terms
- Coffee, Humans, Parkinson Disease, Risk Factors, Smoking, Gastrointestinal Tract, Microbiota
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