Cited by 115Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and SignalingGut microbiota and health

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Gut feelings about smoking and coffee in Parkinson's disease

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Derkinderen, Pascal, Shannon, Kathleen M, Brundin, Patrik·2014·Movement Disorders

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Abstract

Strong epidemiologic evidence suggests that smokers and coffee drinkers have a lower risk of Parkinson's disease (PD). The explanation for this finding is still unknown, and the discussion has focused on two main hypotheses. The first suggests that PD patients have premorbid personality traits associated with dislike for coffee-drinking and smoking. The second posits that caffeine and nicotine are neuroprotective. We propose an alternative third hypothesis, in which both cigarette and coffee consumption change the composition of the microbiota in the gut in a way that mitigates intestinal inflammation. This, in turn, would lead to less misfolding of the protein alpha-synuclein in enteric nerves, reducing the risk of PD by minimizing propagation of the protein aggregates to the central nervous system, where they otherwise can induce neurodegeneration.

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Authors: Derkinderen, P., Shannon, K. M., & Brundin, P.
Affiliations: Inserm (FR)
Rush University Medical Center (US)
Van Andel Institute (US)
Corresponding author: Brundin, Patrik
ORCID: Derkinderen, Pascal
Shannon, Kathleen M
Brundin, Patrik
Venue: Movement Disorders
Publisher: Wiley
Published: 2014-04-21
Volume: 29
Issue: 8
Pages: 976-979
ISSN: 0885-3185 (ISSN-L)
1531-8257
DOI: 10.1002/mds.25882
PMC: PMC4107006
OpenAlex: W1897759802
Cited by: 115
References: 36
Citations by year: 2025: 7 · 2024: 11 · 2023: 5 · 2022: 15 · 2021: 11 · 2020: 9 · 2019: 11 · 2018: 8 · 2017: 16 · 2016: 7 · 2015: 10 · 2014: 4
FWCI: 8.04
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Movement Disorders (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
HAL (submittedVersion)
Funders: National Institute of Neurological Disorders and Stroke (U10NS044475)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: Parkinson's disease, smoking, coffee consumption, gut microbiota, intestinal inflammation, enteric nerves, caffeine, nicotine, neuroprotection, premorbid personality traits, neurodegeneration
MeSH terms: Coffee, Humans, Parkinson Disease, Risk Factors, Smoking, Gastrointestinal Tract, Microbiota

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Gut feelings about smoking and coffee in Parkinson's disease

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