JNK signaling in cancer cell survival

Wu, Qinghua, Wu, Wenda, Fu, Bishi, Shi, Lei, Wang, Xu, Kuca, Kamil·2019·Medicinal Research Reviews

DOI 10.1002/med.21574

Cited by (328)

Items 101–200 of 328

MHY2251, a New SIRT1 Inhibitor, Induces Apoptosis via JNK/p53 Pathway in HCT116 Human Colorectal Cancer Cells
Yong Jung Kang, Young Hoon Kwon, Jung Yoon Jang, Jun Ho Lee, Sanggwon Lee, Yujin Park, Hyung Ryong Moon, Hae Young Chung, Nam Deuk Kim · 2022 · Biomolecules & Therapeutics
Optimizing component formula suppresses lung cancer by blocking DTL-mediated PDCD4 ubiquitination to regulate the MAPK/JNK pathway
Qianqian Fan, Qinwei Lu, Guiyang Wang, Wenjing Zhu, Linxin Teng, Weiping Chen, Lei Bi · 2022 · Journal of Ethnopharmacology
Th1-involved immune infiltrates improve neoadjuvant chemoradiotherapy response of esophageal squamous cell carcinoma
Jianye Yuan, Zelin Weng, Zihui Tan, Kongjia Luo, Jian Zhong, Xiuying Xie, Chunhua Qu, Xiaodan Lin, Hong Yang, Jing Wen et al. · 2022 · Cancer Letters
Inhibition of JNK/c-Jun-ATF2 Overcomes Cisplatin Resistance in Liver Cancer through down-Regulating Galectin-1
Fan Yang, Mengzhu Li, Duo Xu, Zebo Jiang, Hailong Jiang, Yitai Xiao, Chaoming Mei, Meilin Yang, Congmin Chen, Bin Zhou et al. · 2023 · International Journal of Biological Sciences
Aprepitant inhibits the development and metastasis of gallbladder cancer via ROS and MAPK activation
Xueyan Cao, Yang Yang, Wei Zhou, Yue Wang, Xue Bing Wang, Xianxiu Ge, Wang Fei, Fangfang Zhou, Xueting Deng, Lin Miao · 2023 · BMC Cancer
The Molecular Mechanism of Renal Tubulointerstitial Inflammation Promoting Diabetic Nephropathy
Rui Xue, Haiting Xiao, Vinod Kumar, Xiqian Lan, Ashwani Malhotra, Pravin C. Singhal, Jianning Chen · 2023 · International Journal of Nephrology and Renovascular Disease
Therapeutic potential of flavonoids in gastrointestinal cancer: Focus on signaling pathways and improvement strategies (Review)
Ye Ding, Yong Yu · 2025 · Molecular Medicine Reports
Nuclear export protein CSE1L interacts with P65 and promotes NSCLC growth via NF-κB/MAPK pathway
Heping Lin, Jing Li, Dandan Cheng, Xiaoling Zhang, Tao Yu, Fengdong Zhao, Q. Geng, M.X. Zhu, Hualei Kong, H. Li et al. · 2021 · Molecular Therapy — Oncolytics
Inhibition of FOXO1‑mediated autophagy promotes paclitaxel‑induced apoptosis of MDA‑MB‑231 cells
Kaixiang Xu, Wanyun Zhu, Anyong Xu, Zhe Xiong, Di Zou, Heng Zhao, Deling Jiao, Yubo Qing, Muhammad Ameen Jamal, Hong‐Jiang Wei et al. · 2022 · Molecular Medicine Reports
Serving up health: How phytochemicals transform food into medicine in the battle against cancer
Eshita Sharma, Manju Tewari, Priyanka Sati, Isha Sharma, Dharam Chand Attri, Supriyanka Rana, Afaf Ahmed Aldahish, Daniela Cornelia Călina, Praveen Dhyani, Javad Sharifi‐Rad et al. · 2024 · Food Frontiers
Synergy between vinorelbine and afatinib in the inhibition of non-small cell lung cancer progression by EGFR and p53 signaling pathways
Zhen Liu, Qingshan Fu, Yu Wang, Li Cui, Wenqiang Zhang, Yuou Teng, Peng Yu · 2020 · Biomedicine & Pharmacotherapy
RETRACTED ARTICLE: Nrf2 overexpression increases the resistance of acute myeloid leukemia to cytarabine by inhibiting replication factor C4
Tianzhen Hu, Chengyun Pan, Tianzhuo Zhang, Ming Ni, Weili Wang, Siyu Zhang, Ying Chen, Jishi Wang, Qin Fang · 2022 · Cancer Gene Therapy · Retracted
Management of Adverse Reactions for BCMA-Directed Therapy in Relapsed Multiple Myeloma: A Focused Review
Razwana Khanam, Beth M Faiman, Saba Batool, Mohammed Musa Najmuddin, Rana Muhammad Usman, Kiran Kuriakose, Arooj Ahmed, Mohammad Ebad Ur Rehman, Zinath Roksana, Zain Syed et al. · 2023 · Journal of Clinical Medicine
Kaempferide triggers apoptosis and paraptosis in pancreatic tumor cells by modulating the ROS production, SHP ‐1 expression, and the STAT3 pathway
Young Yun Jung, Ninh The Son, Chakrabhavi Dhananjaya Mohan, Jairo Kenupp Bastos, Nguyen Dinh Luyen, Mai Huong Le, Kwang Seok Ahn · 2024 · IUBMB Life
The role of programmed cell death in osteosarcoma: From pathogenesis to therapy
Suqing Liu, Chengtao Liu, Yian Wang, Jiewen Chen, Yujin He, Kaibo Hu, Ting Li, Junmei Yang, Jie Peng, Liang Hao · 2024 · Cancer Medicine
Inhibition of JNK signaling attenuates photoreceptor ferroptosis caused by all-trans-retinal
Bo Yang, Kunhuan Yang, Ruitong Xi, Shiying Li, Jingmeng Chen, Yalin Wu · 2024 · Free Radical Biology and Medicine
The functional role of Pescadillo ribosomal biogenesis factor 1 in cancer
Yongzhi Li, Cheng Zhang, Jun‐Peng Pei, Wanchuan Zhang, Chun‐Dong Zhang, Dong‐Qiu Dai · 2021 · Journal of Cancer
Knockdown of MTHFD2 inhibits proliferation and migration of nasopharyngeal carcinoma cells through the ERK signaling pathway
Sa Wu, Weisong Cai, Zhenxiang Shi, Xiaoping Ming, Xiuping Yang, Yuhao Zhou, Xiong Chen, Minlan Yang · 2022 · Biochemical and Biophysical Research Communications
Janus Kinase-Signal Transducer and Activator of Transcription Inhibitors for the Treatment and Management of Cancer
Fahim Anwar Rizwi, Md. Abubakar, Eswara Rao Puppala, Ahsas Goyal, Ch. Veera Bhadrawamy, V.G.M. Naidu, S. Roshan, Bachi Tazneem, Waleed Hassan Almalki, Vetriselvan Subramaniyan et al. · 2023 · Journal of Environmental Pathology Toxicology and Oncology
Based on Network Pharmacology Tools to Investigate the Mechanism of Tripterygium wilfordii Against IgA Nephropathy
Ming Xia, Di Liu, Haiyang Liu, Juanyong Zhao, Chengyuan Tang, Guochun Chen, Yu Liu, Hong Liu · 2021 · Frontiers in Medicine
Selective Covalent Inhibiting JNK3 by Small Molecules for Parkinson's Diseases
Shuai Wen, Panpan Yang, Huan Xiao, Yumeng Zhu, Faqian Bu, Aoxue Wang, Qiu Sun, Guan Wang, Liang Ouyang · 2024 · Angewandte Chemie International Edition
Mechanism of ferroptosis in heart failure: The role of the RAGE/TLR4-JNK1/2 pathway in cardiomyocyte ferroptosis and intervention strategies
Zeyu Zhang, Zhihua Yang, Shuai Wang, Xianliang Wang, Jingyuan Mao · 2025 · Ageing Research Reviews
Knockdown of TMED3 inhibits cell viability and migration and increases apoptosis in human chordoma cells
Jinxing Yang, Hanwen Huang, Dan Xiao, Yang Duan, Yanfang Zheng, Zhong Chen · 2021 · International Journal of Oncology
Components of the JNK–MAPK pathway play distinct roles in hepatocellular carcinoma
Jijun Yu, Xinying Li, Junxia Cao, Ting Zhu, Shuifeng Liang, Le Du, Meng Cao, Haitao Wang, Yaolin Zhang, Yinxi Zhou et al. · 2023 · Journal of Cancer Research and Clinical Oncology
A small-molecule JNK inhibitor JM-2 attenuates high-fat diet-induced non-alcoholic fatty liver disease in mice
Leiming Jin, Minxiu Wang, Bin Yang, Lin Ye, Weiwei Zhu, Qianhui Zhang, Shuaijie Lou, Yi Zhang, Wu Luo, Guang Liang · 2022 · International Immunopharmacology
Natural products and ferroptosis: A novel approach for heart failure management
Zeyu Zhang, Zhihua Yang, Shuai Wang, Xianliang Wang, Jingyuan Mao · 2025 · Phytomedicine
Sorafenib prevents the proliferation and induces the apoptosis of liver cancer cells by regulating autophagy and hypoxia-inducible factor-1
Qingzhuang Yang, Lianghui Gao, Xiaolong Huang, Jie Weng, Youke Chen, Shibu Lin, Qiushi Yin · 2021 · Experimental and Therapeutic Medicine
Polyacrylonitrile microfibers pose a significant threat to the early-stage survival of zebrafish
Yingying Zhang, Yinan Jiang, Zhu Zhu, Xinrui Xu, Hui Yang · 2023 · Aquatic Toxicology
The Role and Mechanism of ATM-Mediated Autophagy in the Transition From Hyper-Radiosensitivity to Induced Radioresistance in Lung Cancer Under Low-Dose Radiation
Qiong Wang, Yangyang Chen, Haiyan Chang, Ting Hu, Jue Wang, Yuxiu Xie, Jing Cheng · 2021 · Frontiers in Cell and Developmental Biology
RPL35A is a key promotor involved in the development and progression of gastric cancer
Fang Wu, Dachuan Sun, Yuqian Liao, Kai Shang, Canrong Lu · 2021 · Cancer Cell International
CHOP overexpression sensitizes human non-small cell lung cancer cells to cisplatin treatment by Bcl-2/JNK pathway.
Li-Le Wang, Ruicheng Hu, Aiguo Dai, Shuang‐Xiang Tan, Ming Xu, Chunchu Kong, Yunrong Chen, Daiyan Fu · 2021 · PubMed Central
Advances in hyperbaric oxygen to promote immunotherapy through modulation of the tumor microenvironment
Pei Wang, Xiaoyan Wang, Changfeng Man, Dandan Gong, Yu Fan · 2023 · Frontiers in Oncology
α-lipoic acid modulates prostate cancer cell growth and bone cell differentiation
K. M. Abdullah, Gunjan Sharma, Simran Takkar, Jyoti Kaushal, Ramesh Pothuraju, Bandana Chakravarti, Surinder K. Batra, Jawed Akhtar Siddiqui · 2024 · Scientific Reports
A focus on c-Jun-N-terminal kinase signaling in sepsis-associated multiple organ dysfunction: Mechanisms and therapeutic strategies
Riya Gagnani, Mukul Srivastava, Manisha Suri, Harshita Singh, Uma Shanker Navik, Anjana Bali · 2024 · International Immunopharmacology
Artemisia annua L. Polyphenol-Induced Cell Death Is ROS-Independently Enhanced by Inhibition of JNK in HCT116 Colorectal Cancer Cells
Eun Joo Jung, Anjugam Paramanantham, Hye Jung Kim, Sung Chul Shin, Gon Sup Kim, Jin‐Myung Jung, Chung Ho Ryu, Soon‐Chan Hong, Ky Hyun Chung, Choong Won Kim et al. · 2021 · International Journal of Molecular Sciences
Differential regulation of autophagy by STAU1 in alveolar rhabdomyosarcoma and non‐transformed skeletal muscle cells
Shekoufeh Almasi, Tara E. Crawford Parks, Aymeric Ravel‐Chapuis, Alex MacKenzie, Jocelyn Côté, Kyle Northcote Cowan, Bernard Jean Jasmin · 2021 · Cellular Oncology
c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease
Abigail O. Smith, Julie A. Jonassen, Kenley M. Preval, Roger J. Davis, Gregory J. Pazour · 2021 · PLoS Genetics
ZFP36L1 Promotes Gastric Cancer Progression via Regulating JNK and p38 MAPK Signaling Pathways
Kang Ding, Fengping Zhang, Gaoxiu Qi, Meng Lin, Min Chen, Yanchun Chen, Jie Zheng, Fenghua Zhou · 2022 · Recent Patents on Anti-Cancer Drug Discovery
Research progress on the mechanisms of endogenous neural stem cell differentiation in spinal cord injury repair
Tianwei Wang, Qing Han, Shi Lv, Li-ping Zhang, Hengrui Li, Jian Liu, Jinyi Kuang, Baoliang Sun, Jingyi Sun · 2025 · Frontiers in Cellular Neuroscience
Daemonorops draco Blume Induces Apoptosis Against Acute Myeloid Leukemia Cells via Regulation of the miR-216b/c-Jun
Moon Nyeo Park, Hee Won Jeon, Md. Ataur Rahman, Se Sun Park, Se Yun Jeong, Ki Hyun Kim, Sung‐Hoon Kim, Woojin Kim, Bonglee Kim · 2022 · Frontiers in Oncology
The cross-talk of autophagy and apoptosis in breast carcinoma: implications for novel therapies?
Kamil Seyrek, Fabian Wohlfromm, Johannes Espe, Inna N. Lavrik · 2022 · Biochemical Journal
Chinese dragon's blood ethyl acetate extract suppresses gastric cancer progression through induction of apoptosis and autophagy mediated by activation of MAPK and downregulation of the mTOR‐Beclin1 signalling cascade
Lishan Ouyang, Jiaqi Li, Xiaonan Chen, Huiming Huang, Yingying Tian, Xingxing Li, Dao-Ran Pang, Xuejiao Wei, Jinxin Xie, Longyan Wang et al. · 2022 · Phytotherapy Research
Sorafenib Alleviates Inflammatory Signaling of Tumor Microenvironment in Precancerous Lung Injuries
Betül Çiçek, Ahmet Hacımüftüoğlu, Mehmet Kuzucu, Ahmet Cetin, Yeşim Yeni, Sıdıka Genç, Serkan Yıldırım, İsmail Bolat, Mecit Kantarcı, Mustafa Gül et al. · 2023 · Pharmaceuticals
PKC-δ Promotes IL-1β-Induced Apoptosis of Rat Chondrocytes and Via Activating JNK and P38 MAPK Pathways
Jinfeng Lü, Miao Yu, Jia Li · 2023 · Cartilage
Therapeutic potential of ASK1 activators in cancer treatment: Current insights and future directions
Bo Wang, Ying Ma, Yue Zhang, Xunzhe Yin · 2024 · Biomedicine & Pharmacotherapy
HDAC3 genetic and pharmacologic inhibition radiosensitizes fusion positive rhabdomyosarcoma by promoting DNA double-strand breaks
Matteo Cassandri, Antonella Porrazzo, Silvia Pomella, Beatrice Noce, Clemens Zwergel, Francesca Antonella Aiello, Francesca Vulcano, Luisa Milazzo, Simona Camero, Deborah Pajalunga et al. · 2024 · Cell Death Discovery
Discovery of 1-phenyl-1,2,3-triazole ureas as dual VEGFR-2/JNK-1 type II kinase inhibitors targeting pancreatic cancer
Wagdy Mohamed Eldehna, Eslam Roshdy, Maha‐Hamadien Abdulla, Abdelrahman I. Zain-Alabdeen, Moataz Ahmed Shaldam, Noura Sufyan Alhassan, Thamer Bin Traiki, Mohammad Mahmoud Al-Sanea, Anwar A El-Hamaky, Ahmed Ali Al-Karmalawy et al. · 2025 · International Journal of Biological Macromolecules
Aloin induced apoptosis by enhancing autophagic flux through the PI3K/AKT axis in osteosarcoma
Jiaming He, Wenkan Zhang, Xiaozhong Zhou, Weiqi Yan, Zhan Wang · 2021 · Chinese Medicine
Design, synthesis, and biological evaluation of a new series of pyrazole derivatives: Discovery of potent and selective JNK3 kinase inhibitors
Reinad R. Abu Rabah, Anusha Sebastian, Vunnam Srinivasulu, Shaista Sultan, Hamadeh Tarazi, Hanan S. Anbar, Mahmoud K. Shehata, Seyed–Omar Zaraei, Sara M. Elgendy, Salma A. Al Shamma et al. · 2022 · Bioorganic & Medicinal Chemistry
c-Jun N-terminal kinase signaling in aging
Yihao Li, Li You, Eugenie Nepovimová, Vojtěch Adam, Zbyněk Heger, Klaudia Jomová, Marián Valko, Qinghua Wu, Kamil Kuča · 2024 · Frontiers in Aging Neuroscience
Updated insights on ASK1 signaling: mechanisms, regulation, and therapeutic potential in diseases
Divyanshi Thakur, Aniket Nandi, Yash Kumar Gaur, Karthikeyan Chandrabose, Digambar Kumar Waiker, Ghanshyam Das Gupta, Kalicharan Sharma · 2025 · Molecular and Cellular Biochemistry
Research Progress on Autophagy Regulation by Active Ingredients of Traditional Chinese Medicine in the Treatment of Acute Lung Injury
Jin-yan Dong, Honglin Yin, Hao Hao, Yang Liu · 2023 · Journal of Inflammation Research
Fisetin induces G2/M phase arrest and caspase‐mediated cleavage of p21Cip1 and p27Kip1 leading to apoptosis and tumor growth inhibition in HNSCC
Monika Yadav, Kushal Kandhari, Sivapar V. Mathan, Mansoor Ali, Rana Pratap Singh · 2024 · Molecular Carcinogenesis
PMEPA1 facilitates non-small cell lung cancer progression via activating the JNK signaling pathway
Benxu Tan, Yonghong Chen, Lei Xia, Xianjun Yu, Yuan Peng, Xiaoyue Zhang, Zhenzhou Yang · 2021 · Cancer Biomarkers
ANLN Serves as an Oncogene in Bladder Urothelial Carcinoma via Activating JNK Signaling Pathway
Sheng Chen, Yi Gao, Fei Chen, Tianbao Wang · 2022 · Urologia Internationalis
Microcystin-LR accelerates follicular atresia in mice via JNK-mediated adherent junction damage of ovarian granulosa cells
Xingde Du, Yu Fu, Zhihui Tian, Haohao Liu, Hongxia Xin, Xiaoli Fu, Fufang Wang, Huizhen Zhang, Xin Zeng · 2023 · Ecotoxicology and Environmental Safety
JNK and Yorkie drive tumor malignancy by inducing L-amino acid transporter 1 in Drosophila
Bojie Cong, Mai Nakamura, Yukari Sando, Takefumi Kondo, Shizue Ohsawa, Tatsushi Igaki · 2021 · PLoS Genetics
MAP4K signaling pathways in cancer: roles, mechanisms and therapeutic opportunities
Chyntia Sherlyn Bunardi, Minseo Yeom, Prisca Kosasih, Han Han, Wenqi Wang, Gayoung Seo · 2025 · Experimental & Molecular Medicine
Evaluation of nanoplastics-induced redox imbalance in cells, larval zebrafish, and daphnia magna with a superoxide anion radical fluorescent probe
Yicheng Wang, Yan Huang, Lili Fu, Xiaoyan Wang, Lingxin Chen · 2024 · Chemosphere
Neurokinin‐1 receptor antagonist aprepitant regulates autophagy and apoptosis via ROS / JNK in intrahepatic cholangiocarcinoma
Yang Yang, Xueyan Cao, Yuting Wang, Xinyu Wu, Ping Zhou, Lin Miao, Xueting Deng · 2024 · Liver International
The Cytotoxic Activity of Secondary Metabolites from Marine-Derived Penicillium spp.: A Review (2018–2024)
Shuncun Zhang, Huannan Wang, Chunmei Sai, Yan Wang, Zhongbin Cheng, Zhen Zhang · 2025 · Marine Drugs
Targeting BCMA to Treat Multiple Myeloma: Updates From the 2021 ASH Annual Meeting
Ruiting Guo, Wenyi Lu, Yi Zhang, Xinping Cao, Xin Kinson Jin, Mingfeng Zhao · 2022 · Frontiers in Immunology
Tumor elimination by clustered microRNAs miR-306 and miR-79 via noncanonical activation of JNK signaling
Zhaowei Wang, Xiaoling Xia, Jiaqi Li, Tatsushi Igaki · 2022 · eLife
Autophagy in Intracerebral Hemorrhage: From Mechanism to Regulation
Jia Zheng, Wei Zou, Xueping Yu · 2023 · Journal of Integrative Neuroscience
SHP2 potentiates anti-PD-1 effectiveness through intervening cell pyroptosis resistance in triple-negative breast cancer
Chao Chen, Yuanyuan Cheng, Haoqi Lei, Xuefei Feng, Hongxia Zhang, Lingling Qi, Jufeng Wan, Haiying Xu, Xin Yu Zhao, Yan Zhang et al. · 2023 · Biomedicine & Pharmacotherapy
Propofol Attenuates Hypoxia/Reoxygenation-Induced Apoptosis and Autophagy in HK-2 Cells by Inhibiting JNK Activation
Huaxin Wang, Xuan Peng, Yayi Huang, Yeda Xiao, Zhuo Wang, Liying Zhan · 2019 · Yonsei Medical Journal
Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases
Yiqiang Zhi, Xiaokun Zhou, Jurui Yu, Ling Yuan, Hongsheng Zhang, Dominic C.H. Ng, Zhiheng Xu, Dan Xu · 2021 · Frontiers in Cell and Developmental Biology
Meso‐Hannokinol inhibits breast cancer bone metastasis via the ROS / JNK / ZEB1 axis
Yuan Zhu, Wei‐feng Yin, Pei Yu, Chao Zhang, Ming‐hui Sun, Lingyi Kong, Lei Yang · 2023 · Phytotherapy Research
The SIX2/PFN2 feedback loop promotes the stemness of gastric cancer cells
Qianqian Guo, Yi Zhou, Haiwei Ni, Miaomiao Niu, Shengtao Xu, Lufeng Zheng, Wenzhou Zhang · 2024 · Journal of Translational Medicine
Chinese medicine in the treatment of chronic hepatitis B: The mechanisms of signal pathway regulation
Shihao Zheng, Wenying Qi, Tianyu Xue, Xiaobin Zao, Jinchi Xie, Peng Zhang, Xiaoke Li, Yongan Ye, Aimin Liu · 2024 · Heliyon
Oleanolic acid activates the JNK-Sp1-DJ-1 axis to promote mitophagy-mediated neuroprotection in dopaminergic neurons for Parkinson’s disease treatment
Han-Bin Yang, Chien-Hsing Lee, Nguyen Thao Nhung, Shih‐Ya Hung · 2025 · Archives of Pharmacal Research
Macrophages promote tumor growth by phagocytosis-mediated cytokine amplification in Drosophila
Eri Hirooka, Ryo Hattori, Keisuke Ikawa, Tomoe Kobayashi, Makoto Matsuyama, Tatsushi Igaki, Shizue Ohsawa · 2025 · Current Biology
Celastrol-mediated autophagy regulation in cancer
Muhammad Haroon, Sun Chul Kang · 2020 · Applied Biological Chemistry
Role of ROR2 in promoting gastric cancer metastasis by enhancing c-JUN-mediated MMP3 transcription
Xiaoxiao Ge, Fengjuan Lin, Zheng Lai Wu, Ying Lin, Wenbo Tang, Michael Jerome McKay, Arvind Sahu, Leonardo Saul Lino-Silva, Joshua Tseng, Jin Li · 2022 · Annals of Translational Medicine
RETRACTED: miR-33b in human cancer: Mechanistic and clinical perspectives
Wenlong Zhang, Bincan Jiang, Hecheng Zhu, Ailan Cheng, Can Li, Haoxuan Huang, Xuewen Li, Yirui Kuang · 2023 · Biomedicine & Pharmacotherapy · Retracted
Apoptosis-Induced Compensatory Proliferation in Cancer
Ulisses Moreno‐Celis, Teresa García-Gasca, Carmen Mejía · 2021 · Exon Publications eBooks
Identification of Senescence-Related Subtypes, the Development of a Prognosis Model, and Characterization of Immune Infiltration and Gut Microbiota in Colorectal Cancer
Juji Dai, Yangyang Fu, Xiqiang Zhong, Wei Cen, Mao-Fei Ye, Xi-Han Chen, Yifei Pan, Lechi Ye · 2022 · Frontiers in Medicine
Extracellular adenosine oppositely regulates the purinome machinery in glioblastoma and mesenchymal stem cells
Deborah Pietrobono, Lara Russo, Maria Sofia Bertilacchi, Laura Marchetti, Claudia Martini, Chiara Giacomelli, Maria Letizia Trincavelli · 2024 · IUBMB Life
Tumor cell cycle regulation: integrated perspective of stage characteristics, regulatory networks, and signaling pathway intervention strategies
Qing Wan, Zhongmin Yang, Lian Huang, Yang Xia, Lihua Long, Zucai Xu, Jida Li · 2026 · Molecular Biomedicine
Role of F-box proteins in human upper gastrointestinal tumors
Che Zhang, Guangzhao Pan, Jiang‐Jiang Qin · 2023 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Programmable activation of berbamine and photosensitizers for enhanced photodynamic therapy using emission-switchable upconversion nanoparticles
Tao Zhu, Zhiyuan Lin, Xiaoli Tang, Jinliang Liu, Yong Zhang, Xiaoqin Zhong · 2024 · International Journal of Pharmaceutics
Combined blockade of GPX4 and activated EGFR / HER3 bypass pathways inhibits the development of ALK ‐inhibitor‐induced tolerant persister cells in ALK ‐fusion‐positive lung cancer
Koh Furugaki, Takaaki Fujimura, Narumi Sakaguchi, Yasutaka Watanabe, Ken Uchibori, Eisaku Miyauchi, Hidetoshi Hayashi, Ryohei Katayama, Shigeki Yoshiura · 2024 · Molecular Oncology
Research Progress of Indole Alkaloids: Targeting MAP Kinase Signaling Pathways in Cancer Treatment
Md. Al Amin, Talha Bin Emran, Jishan Khan, Mehrukh Zehravi, Indu Sharma, Anasuya Patil, Jeetendra Kumar Gupta, D. Jeslin, Karthickeyan Krishnan, Rajib Chandra Das et al. · 2023 · Cancers
Clinical efficacy and potential mechanism of ginseng polysaccharides in the treatment of non-small cell lung cancer based on meta-analysis associated with network pharmacology
Qi Zhao, Le Bai, Dongwei Zhu, Tingyuan Li, Jie Xu, Yong Xu, Xianmei Zhou · 2024 · Heliyon
Anticancer role of flubendazole: Effects and molecular mechanisms (Review)
Xing Xing, Zongning Zhou, Hongwei Peng, Shaoping Cheng · 2024 · Oncology Letters
Genome-wide p63-Target Gene Analyses Reveal TAp63/NRF2-Dependent Oxidative Stress Responses
Marco Napoli, Avani A. Deshpande, Deepavali Chakravarti, Kimal Rajapakshe, Preethi H. Gunaratne, Cristian Coarfa, Elsa Renee Flores · 2024 · Cancer Research Communications
The emerging role of circular RNAs in cisplatin resistance in ovarian cancer: From molecular mechanism to future potential
Mohaddese Malek Mohammadi, Hamidreza Rismanchi, Shakiba Esmailzadeh, Aryan Farahani, Neda Hedayati, Mina Alimohammadi, Alireza Mafi, Najma Farahani, Kiavash Hushmandi · 2024 · Non-coding RNA Research
Update on JNK inhibitor patents: 2015 to present
Guotai Feng, Xiao Yang, Shuai Wen, Guan Wang, Liang Ouyang · 2024 · Expert Opinion on Therapeutic Patents
Structure Optimization of c-Jun N-terminal Kinase 1 Inhibitors for Treating Idiopathic Pulmonary Fibrosis
Yi Huang, Fengling Liu, Shuhua Ren, Yuanqing Ding, Man Chi, Weiwei Huang, Wenjing Gu, Hewen Qian, Yaxia Yuan, Shurong Hou et al. · 2024 · Journal of Medicinal Chemistry
Low-intensity pulsed ultrasound combined with microbubble mediated JNK/c-Jun pathway to reverse multidrug resistance in triple-negative breast cancer
Nina Qu, Zhihui Wu, Qingkai Meng, Menglu Bi, Hexiu Liu, Xiaoli Cao, Yanqing Liu · 2024 · Scientific Reports
Kinase Inhibitors Involved in the Regulation of Autophagy: Molecular Concepts and Clinical Implications
Isehaq Al‐Huseini, Srinivasa Rao Sirasanagandla, K. Suresh Babu, R. G. S. Sofin, Srijit Das · 2022 · Current Medicinal Chemistry
Pre exposure to enriched environment alleviates brain injury after ischemia-reperfusion by inhibiting p38MAPK/STAT1 pathway
Xin-Ya Shen, Yu Han, Zhen-Kun Gao, Ping-Ping Han, Xia Bi · 2022 · Molecular Biology Reports
SPG21, a potential oncogene targeted by miR-128-3p, amplifies HBx-induced carcinogenesis and chemoresistance via activation of TRPM7-mediated JNK pathway in hepatocellular carcinoma
Ping Zhou, Wei Yao, Lijuan Liu, Qiujin Yan, Xiaobei Chen, Xiaocui Wei, Shuang Ding, Zhao Lv, Fan Zhu · 2024 · Cellular Oncology
Enhancing radiosensitivity of osteosarcoma by ITGB3 knockdown: a mechanism linked to enhanced osteogenic differentiation status through JNK/c-JUN/RUNX2 pathway activation
Qiujian Lian, Hu Liu, Jingyan Li, Cheng Luo, Chang Liu, Haonan Zhao, Peijun Dai, Bingxuan Wang, Huipeng Zhou, Xin Jian Jiang et al. · 2025 · Journal of Experimental & Clinical Cancer Research
miR-155 aberrant expression impairs tumor rejection because of its targeting of ICOSL and multiple pathways implicated in the antitumor response
Esmerina Tili, Jean‐Jacques Michaille, Carlo Maria Croce · 2025 · Pharmacological Reviews
Growth of T-cell lymphoma cells is inhibited by mPGES-1/PGE2 suppression via JAK/STAT, TGF-β/Smad3 and PI3K/AKT signal pathways
Yiqing Li, Meng Qiu, Boqi Li, Jie Xiao, Wenjuan Yang, Shuangfeng Xie, Yumo Du, Kezhi Huang, Danian Nie · 2022 · Translational Cancer Research
The lincRNA JUNI regulates the stress-dependent induction of c-Jun, cellular migration and survival through the modulation of the DUSP14-JNK axis
Vikash Kumar, Xavier Sabaté-Cadenas, Isha Soni, Esther Stern, Carine Vias, Doron Ginsberg, Carlos Romá Mateo, Rafael Pulido, Martin Dodel, Faraz K. Mardakheh et al. · 2024 · Oncogene
Remote ischemia precondition protects against renal IRI through apoptosis associated vesicles carrying MIF protein via modulating DUSP6/JNK signaling axis
Nieke Zhang, Zhicong Huang, Yi Xin Xia, Shuchun Tao, Tiange Wu, Si Sun, Yongkun Zhu, Guiya Jiang, Xun Lu, Yue Gao et al. · 2025 · Journal of Nanobiotechnology
Cell-cell and cell-substratum contacts in the regulation of MAPK and Akt signalling: Importance in therapy, biopharmacy and bioproduction
Aurimas Stulpinas, Tomas Uzusienis, Aušra Imbrasaitė, Natalija Krestnikova, Aušra Ungurytė, Audronė Valerija Kalvelytė · 2021 · Cellular Signalling
Combined treatment with inhibitors of ErbB Receptors and Hh signaling pathways is more effective than single treatment in reducing the growth of malignant mesothelioma both in vitro and in vivo
Roberto Bei, Monica Benvenuto, Chiara Focaccetti, Sara Fazi, Marta Moretti, Daniela Nardozi, Valentina Angiolini, Sara Ciuffa, Loredana Cifaldi, Raffaele Carrano et al. · 2022 · Journal of Translational Medicine