Cited by 328NF-κB Signaling PathwaysProtein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

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JNK signaling in cancer cell survival

Wu, Qinghua, Wu, Wenda, Fu, Bishi, Shi, Lei, Wang, Xu, Kuca, Kamil·2019·Medicinal Research Reviews

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Abstract

c‐Jun N‐terminal kinase (JNK) is involved in cancer cell apoptosis; however, emerging evidence indicates that this Janus signaling promotes cancer cell survival. JNK acts synergistically with NF‐κB, JAK/STAT, and other signaling molecules to exert a survival function. JNK positively regulates autophagy to counteract apoptosis, and its effect on autophagy is related to the development of chemotherapeutic resistance. The prosurvival effect of JNK may involve an immune evasion mechanism mediated by transforming growth factor‐β, toll‐like receptors, interferon‐γ, and autophagy, as well as compensatory JNK‐dependent cell proliferation. The present review focuses on recent advances in understanding the prosurvival function of JNK and its role in tumor development and chemoresistance, including a comprehensive analysis of the molecular mechanisms underlying JNK‐mediated cancer cell survival. There is a focus on the specific “Yin and Yang” functions of JNK1 and JNK2 in the regulation of cancer cell survival. We highlight recent advances in our knowledge of the roles of JNK in cancer cell survival, which may provide insight into the distinct functions of JNK in cancer and its potential for cancer therapy.

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Sui, X., Kong, N., Wang, X., Fang, Y., Hu, X., Xu, Y., Chen, W., Wang, K., Li, D., Jin, W., et al. (2014) · Scientific Reports · doi:10.1038/srep04694 · Cited by 96
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Protocatechuic Acid Prevents oxLDL-Induced Apoptosis by Activating JNK/Nrf2 Survival Signals in Macrophages
Varı́, R., Scazzocchio, B., Santangelo, C., Filesi, C., Galvano, F., D’Archivio, M., Masella, R., & Giovannini, C. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/351827 · Cited by 41
Retracted
Superior efficacy of the antifungal agent ciclopirox olamine over gemcitabine in pancreatic cancer models
Mihailidou, C., Papakotoulas, P., Papavassiliou, A. G., & Karamouzis, M. V. (2017) · Oncotarget · doi:10.18632/oncotarget.23164 · Cited by 31
Retracted
Patterns of somatic mutation in human cancer genomes
Greenman, C. D., Stephens, P., Smith, R., Dalgliesh, G. L., Hunter, C., Bignell, G. R., Davies, H. R., Teague, J. W., Butler, A. P., Stevens, C., et al. (2007) · Nature · doi:10.1038/nature05610 · Cited by 3,143
Signal integration by JNK and p38 MAPK pathways in cancer development
Wagner, E. F., & Nebreda, Á. R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2694 · Cited by 2,635
The STATs of cancer — new molecular targets come of age
Yu, H., & Jove, R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1275 · Cited by 2,278
Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress
Ogata, M., Hino, S.-I., Saito, A., Morikawa, K., Kondo, S., Kanemoto, S., Murakami, T., Taniguchi, M., Tanii, I., Yoshinaga, K., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01453-06 · Cited by 1,832
Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway
Tournier, C., Hess, P., Yang, D. D., Xu, J., Turner, T. K., Nimnual, A., Bar-Sagi, D., Jones, S. N., Flavell, R. A., & Davis, R. J. (2000) · Science · doi:10.1126/science.288.5467.870 · Cited by 1,728
TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance
Thomas, D. A., & Massagué, J. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.10.012 · Cited by 1,355
JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy
Wei, Y., Pattingre, S., Sinha, S., Bassik, M., & Levine, B. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.06.001 · Cited by 1,329

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Moreira, B. P., Gava, S. G., Haeberlein, S., Gueye, S., dos Santos, E. S. S., Weber, M. H. W., Abramyan, T. M., Grevelding, C. G., Mourão, M. D. M., & Falcone, F. H. (2024) · Frontiers in Parasitology · doi:10.3389/fpara.2024.1394407 · Cited by 7
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Authors: Wu, Q., Wu, W., Fu, B., Shi, L., Wang, X., & Kuca, K.
Affiliations: Nanjing Agricultural University (CN)
Harvard University (US)
University of Manchester (GB)
Huazhong Agricultural University (CN)
Department of Chemistry Faculty of Science, University of Hradec Kralove Hradec Kralove Czech Republic
Corresponding author: Wang, Xu
ORCID: Wu, Qinghua
Wu, Wenda
Fu, Bishi
Wang, Xu
Kuca, Kamil
Venue: Medicinal Research Reviews
Publisher: Wiley
Published: 2019-03-25
Volume: 39
Issue: 6
Pages: 2082-2104
ISSN: 0198-6325 (ISSN-L)
1098-1128
DOI: 10.1002/med.21574
OpenAlex: W2923315793
Cited by: 322
References: 146
Citations by year: 2026: 22 · 2025: 51 · 2024: 68 · 2023: 42 · 2022: 56 · 2021: 43 · 2020: 29 · 2019: 11
FWCI: 3.40
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Medicinal Research Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (31572575, 31602114)
China Postdoctoral Science Foundation (2016T90477)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
Keywords: JNK signaling, c-Jun N-terminal kinase, tumor cell survival, apoptosis, NF-κB, JAK/STAT signaling, autophagy, chemoresistance, immune evasion, TGF-beta, Toll-like receptors, interferon-gamma, JNK1, JNK2, carcinogenesis, cell proliferation
MeSH terms: Animals, Autophagy, Cell Survival, Humans, Neoplasms, Drug Resistance, Neoplasm, MAP Kinase Signaling System, JNK Mitogen-Activated Protein Kinases

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