JNK signaling in cancer cell survival

Wu, Qinghua; Wu, Wenda; Fu, Bishi; Shi, Lei; Wang, Xu; Kuca, Kamil

doi:10.1002/med.21574

Cited by 328NF-κB Signaling PathwaysProtein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

JNK signaling in cancer cell survival

Wu, Qinghua, Wu, Wenda, Fu, Bishi, Shi, Lei, Wang, Xu, Kuca, Kamil·2019·Medicinal Research Reviews

DOI 10.1002/med.21574

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Abstract

c‐Jun N‐terminal kinase (JNK) is involved in cancer cell apoptosis; however, emerging evidence indicates that this Janus signaling promotes cancer cell survival. JNK acts synergistically with NF‐κB, JAK/STAT, and other signaling molecules to exert a survival function. JNK positively regulates autophagy to counteract apoptosis, and its effect on autophagy is related to the development of chemotherapeutic resistance. The prosurvival effect of JNK may involve an immune evasion mechanism mediated by transforming growth factor‐β, toll‐like receptors, interferon‐γ, and autophagy, as well as compensatory JNK‐dependent cell proliferation. The present review focuses on recent advances in understanding the prosurvival function of JNK and its role in tumor development and chemoresistance, including a comprehensive analysis of the molecular mechanisms underlying JNK‐mediated cancer cell survival. There is a focus on the specific “Yin and Yang” functions of JNK1 and JNK2 in the regulation of cancer cell survival. We highlight recent advances in our knowledge of the roles of JNK in cancer cell survival, which may provide insight into the distinct functions of JNK in cancer and its potential for cancer therapy.

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The JAK/STAT pathway interacts with the RAS/MAPK and NF-κB signaling pathways, forming a complex network that influences proliferation, survival, and apoptosis.
“The JAK/STAT pathway interacts with the RAS/MAPK and NF-κB signaling pathways, forming a complex network of cross-talk that influences various cellular processes, including cell proliferation, survival, and apoptosis.”
From Multiple myeloma: signaling pathways and targeted therapy (2024) · cites this paper as [118]
The JAK/STAT pathway, through its downstream effector Zfh2, controls expression of the fos gene and the pro-apoptotic hid gene, promoting JNK-mediated cell survival and inhibiting JNK-induced apoptosis.
“However, the JAK/STAT pathway, through its downstream effector Zfh2, can control the expression of the fos gene and the pro-apoptotic hid gene, thereby promoting cell survival mediated by JNK and inhibiting JNK-induced cell apoptosis [118].”
From Multiple myeloma: signaling pathways and targeted therapy (2024) · cites this paper as [118]

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Increased JNK1 Signaling Pathway Is Responsible for ABCG2-Mediated Multidrug Resistance in Human Colon Cancer
Zhu, M., Tong, J. L., Xu, Q., Nie, F., Xi Tao, X. U., Shu Dong, X. I. A. O., & Ran, Z. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041763 · Cited by 59 · see citing works
Galectin-7 Regulates Keratinocyte Proliferation and Differentiation through JNK-miR-203-p63 Signaling
Chen, H.-L., Chiang, P.-C., Lo, C.-H., Lo, Y., Hsu, D. K., Chen, H., & Liu, F. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.366 · Cited by 58 · see citing works
Pro-survival effects of JNK and p38 MAPK pathways in LPS-induced activation of BV-2 cells
Svensson, C., Part, K., Künnis-Beres, K., Kaldmäe, M., Fernaeus, S. Z., & Land, T. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.02.083 · Cited by 56 · see citing works
JNK and Macroautophagy Activation by Bortezomib Has a Pro-Survival Effect in Primary Effusion Lymphoma Cells
Granato, M., Santarelli, R., Lotti, L. V., Renzo, L. D., Gonnella, R., Garufi, A., Trivedi, P., Frati, L., D’Orazi, G., Faggioni, A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075965 · Cited by 55 · see citing works
Tumor Immune Evasion
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Overexpression of c-Jun contributes to sorafenib resistance in human hepatoma cell lines
Haga, Y., Kanda, T., Nakamura, M., Nakamoto, S., Sasaki, R., Takahashi, K., Wu, S., & Yokosuka, O. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174153 · Cited by 52 · see citing works
TBP Is Differentially Regulated by c-Jun N-Terminal Kinase 1 (JNK1) and JNK2 through Elk-1, Controlling c-Jun Expression and Cell Proliferation
Zhong, S., Longo, J. F., & Johnson, D. L. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01365-06 · Cited by 50 · see citing works
TGF-β1 enhances tumor-induced angiogenesis via JNK pathway and macrophage infiltration in an improved zebrafish embryo/xenograft glioma model
Yang, X., Chen, G.-L., Yu, S., Xu, C. S., Xin, Y.-H., Li, T., Shi, Y., Ai, G., Duan, J., Qian, C., et al. (2012) · International Immunopharmacology · doi:10.1016/j.intimp.2012.12.002 · Cited by 48 · see citing works
Heme oxygenase-1 suppresses the apoptosis of acute myeloid leukemia cells via the JNK/c-JUN signaling pathway
Lin, X., Fang, Q., Chen, S., Zhe, N., Chai, Q., Yu, M., Zhang, Y., Wang, Z., & Wang, J. (2015) · Leukemia Research · doi:10.1016/j.leukres.2015.02.009 · Cited by 47 · see citing works
Role of C-Jun N-terminal Kinase in Hepatocellular Carcinoma Development
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Jun Kinase Delays Caspase-9 Activation by Interaction with the Apoptosome
Tran, T., Andreka, P. G., Rodrigues, C. O., Webster, K. A., & Bishopric, N. H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702210200 · Cited by 45 · see citing works
Drug resistance of bladder cancer cells through activation of ABCG2 by FOXM1
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Doxorubicin induces expression of multidrug resistance-associated protein 1 in human small cell lung cancer cell lines by the c-jun N-terminal kinase pathway
Shinoda, C., Maruyama, M., 藤下, 隆., Dohkan, J., Oda, H., Shinoda, K., Yamada, T., Miyabayashi, K., Hayashi, R., Kawagishi, Y., et al. (2005) · International Journal of Cancer · doi:10.1002/ijc.21094 · Cited by 45 · see citing works
Targeting STAT3 phosphorylation by neem leaf glycoprotein prevents immune evasion exerted by supraglottic laryngeal tumor induced M2 macrophages
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Functional p38 MAPK Identified by Biomarker Profiling of Pancreatic Cancer Restrains Growth through JNK Inhibition and Correlates with Improved Survival
Zhong, Y., Naito, Y., Cope, L., Naranjo‐Suarez, S., Saunders, T., Hong, S., Goggins, M., Herman, J. M., Wolfgang, C. L., & Iacobuzio–Donahue, C. A. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2823 · Cited by 44 · see citing works
TLE4 promotes colorectal cancer progression through activation of JNK/c-Jun signaling pathway
Wang, S., Gao, K., Deng, D., Cai, J., Xiao, Z., He, L., Jiao, H., Ye, Y., Yang, R., Li, T., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6694 · Cited by 44 · see citing works
Toll-like receptor 4 signaling promotes invasion of hepatocellular carcinoma cells through MKK4/JNK pathway
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Crosstalk of JNK1-STAT3 is critical for RAW264.7 cell survival
Wu, Q., Wang, X., Wan, D., Li, J., & Yuan, Z. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.09.013 · Cited by 43 · see citing works
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Crosstalk between JNK and NF-κB signaling pathways via HSP27 phosphorylation in HepG2 cells
Ruan, J., Qi, Z., Shen, L., Jiang, Y., Xu, Y., Lan, L., Luo, L., & Yin, Z. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.11.045 · Cited by 42 · see citing works
JNK1 Inhibition Attenuates Hypoxia-Induced Autophagy and Sensitizes to Chemotherapy
Vasilevskaya, I. A., Selvakumaran, M., Roberts, D., & O'Dwyer, P. J. (2016) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0035 · Cited by 40 · see citing works
mTORC1 pathway mediates beta cell compensatory proliferation in 60 % partial-pancreatectomy mice
Li, W., Zhang, H., Nie, A., Ni, Q., Li, F., Ning, G., Li, X., Gu, Y., & Wang, Q. (2016) · Endocrine · doi:10.1007/s12020-016-0861-5 · Cited by 39 · see citing works
Anti-proliferation of triple-negative breast cancer cells with physagulide P: ROS/JNK signaling pathway induces apoptosis and autophagic cell death
Yu, P., Zhang, C., Gao, C., Ma, T., Zhang, H., Zhou, M., Yang, Y.-W., Yang, L., & Kong, L. (2017) · Oncotarget · doi:10.18632/oncotarget.19299 · Cited by 38 · see citing works
Activation of JNK by TPA promotes apoptosis via PKC pathway in gastric cancer cells
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Blocking autophagy enhances the apoptotic effect of 18β-glycyrrhetinic acid on human sarcoma cells via endoplasmic reticulum stress and JNK activation
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cJun N-terminal kinase (JNK) mediates cortico-striatal signaling in a model of Parkinson's disease
Spigolon, G., Cavaccini, A., Trusel, M., Tonini, R., & Fisone, G. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.10.015 · Cited by 34 · see citing works
Basal Cancer Cell Survival Involves JNK2 Suppression of a Novel JNK1/c-Jun/Bcl-3 Apoptotic Network
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Midazolam anesthesia protects neuronal cells from oxidative stress-induced death via activation of the JNK-ERK pathway
Liu, J., Guo, F., Wu, H., Wang, Y., & Liu, J.-S. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.6031 · Cited by 34 · see citing works
Endothelin‐1 protects human melanocytes from UV ‐induced DNA damage by activating JNK and p38 signalling pathways
von Koschembahr, A., Swope, V. B., Starner, R. J., & ABDEL‐MALEK, Z. A. (2015) · Experimental Dermatology · doi:10.1111/exd.12638 · Cited by 32 · see citing works
Cancer associated fibroblasts tailored tumor microenvironment of therapy resistance in gastrointestinal cancers
Sun, Y., Wang, R., Qiao, M., Yan-chun, X., Guan, W., & Wang, L. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26433 · Cited by 32 · see citing works
Role of mitogen-activated protein kinase signaling in the pathogenesis of dengue virus infection
Sreekanth, G. P., Yenchitsomanus, P., & Limjindaporn, T. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.05.002 · Cited by 32 · see citing works
SP600125, an inhibitor of Jnk pathway, reduces viability of relatively resistant cancer cells to doxorubicin
Kim, J.-H., Kim, T. H., Kang, H. S., Ro, J., Kim, H. S., & Yoon, S. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.07.036 · Cited by 32 · see citing works
Contribution of persistent C-Jun N-terminal kinase activity to the survival of human vestibular schwannoma cells by suppression of accumulation of mitochondrial superoxides
Yue, W., Clark, J. J., Fernando, A., Domann, F. E., & Hansen, M. R. (2011) · Neuro-Oncology · doi:10.1093/neuonc/nor068 · Cited by 31 · see citing works
Autophagy activated by the c-Jun N-terminal kinase-mediated pathway protects human prostate cancer PC3 cells from celecoxib-induced apoptosis
Zhu, X., Zhou, M., Guanyu, L., Huang, X., He, W., Gou, X., & Jiang, T. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4287 · Cited by 31 · see citing works
Involvement of the c-jun N-terminal kinases JNK1 and JNK2 in complement-mediated cell death
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Tumour growth and immune evasion as targets for a new strategy in advanced cancer
Nicolini, A., Ferrari, P., Rossi, G., & Carpi, A. (2018) · Endocrine Related Cancer · doi:10.1530/erc-18-0142 · Cited by 29 · see citing works
Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion
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Oppositional Regulation of Noxa by JNK1 and JNK2 during Apoptosis Induced by Proteasomal Inhibitors
Pietkiewicz, S., Sohn, D., Piekorz, R. P., Grether‐Beck, S., Budach, W., Sabapathy, K., & Jänicke, R. U. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061438 · Cited by 25 · see citing works
Autophagy-independent function of Atg1 for apoptosis-induced compensatory proliferation
Li, M., Lindblad, J. L., Perez, E., Bergmann, A., & Fan, Y. (2016) · BMC Biology · doi:10.1186/s12915-016-0293-y · Cited by 25 · see citing works
Activation of a c-Jun N-terminal kinase-mediated autophagy pathway attenuates the anticancer activity of gemcitabine in human bladder cancer cells
Huang, X., Zhang, H., Yang, X., Dong, X., Xie, X. S., Yin, H., Gou, X., Lin, Y., & He, W. (2017) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000000499 · Cited by 24 · see citing works
Autophagy blockade sensitizes the anticancer activity of CA-4 via JNK-Bcl-2 pathway
Li, Y., Luo, P., Wang, J., Dai, J., Yang, X., Wu, H., Yang, B., & He, Q. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.11.018 · Cited by 23 · see citing works
Foxo1 Attenuates NaF-Induced Apoptosis of LS8 Cells through the JNK and Mitochondrial Pathways
Li, J., Zhao, L., Zhao, X., Wang, P., Liu, Y., & Ruan, J. (2017) · Biological Trace Element Research · doi:10.1007/s12011-017-1015-1 · Cited by 23 · see citing works
CIP2A overexpression induces autoimmune response and enhances JNK signaling pathway in human lung cancer
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Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors
He, Y., Duckett, D. R., Chen, W., Ling, Y. Y., Cameron, M. D., Li, L., Ruiz, C. H., LoGrasso, P. V., Kamenecka, T. M., & Koenig, M. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.11.052 · Cited by 22 · see citing works
Signalling pathways involved in clinical responses to chemotherapy
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The NAB-Brk Signal Bifurcates at JNK to Independently Induce Apoptosis and Compensatory Proliferation
Suissa, Y., Oren, Z., Dinur, T., Arama, E., & Gerlitz, O. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.193235 · Cited by 21 · see citing works
TAK1–JNK Axis Mediates Survival Signal through Mcl1 Stabilization in Activated T Cells
Hirata, Y., Sugie, A., Matsuda, A., Matsuda, S., & Koyasu, S. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202809 · Cited by 21 · see citing works
An In Vivo Functional Screen Identifies JNK Signaling As a Modulator of Chemotherapeutic Response in Breast Cancer
Ashenden, M., van Weverwijk, A., Murugaesu, N., Fearns, A., Campbell, J., Gao, Q., Iravani, M., & Isacke, C. M. (2017) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-16-0731 · Cited by 21 · see citing works
STAT3-enhancing germline mutations contribute to tumor-extrinsic immune evasion
Kogan, D., Grabner, A., Yanucil, C., Faul, C., & Ulaganathan, V. K. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96708 · Cited by 21 · see citing works
JNK and JAK/STAT signalling are required for inducing loss of cell fate specification during imaginal wing discs regeneration in Drosophila melanogaster
Ahmed-de-Prado, S., Díaz-García, S., & Baonza, A. (2018) · Developmental Biology · doi:10.1016/j.ydbio.2018.05.021 · Cited by 21 · see citing works
The c-Jun N-terminal kinase inhibitor SP600125 inhibits human cytomegalovirus replication
Zhang, H., Niu, X., Qian, Z., Qian, J., & Xuan, B. (2015) · Journal of Medical Virology · doi:10.1002/jmv.24286 · Cited by 21 · see citing works
JNK activation is required for TNFα-induced apoptosis in human hepatocarcinoma cells
Minero, V. G., Khadjavi, A., Costelli, P., Baccino, F. M., & Bonelli, G. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.05.017 · Cited by 20 · see citing works
Inhibition of JNK and prothymosin-alpha sensitizes hepatocellular carcinoma cells to cisplatin
Lin, Y.-T., Liu, Y., & Chao, C. C. ‐. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.10.003 · Cited by 20 · see citing works
Attenuated JNK signaling in multidrug-resistant leukemic cells. Dual role of MAPK in cell survival
Cerezo, D., Ruiz‐Alcaraz, A. J., Lencina, M., Cánovas, M., García–Peñarrubia, P., Martínez-López, I., & Martín‐Orozco, E. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.12.003 · Cited by 19 · see citing works
Ligation of IFN-γ-induced HLA-DR molecules on fibroblasts induces RANTES expression via c-Jun N-terminal kinase (JNK) pathway
Meguro, M., Nishimura, F., Ohyama, H., Takashiba, S., Murayama, Y., & Matsushita, S. (2003) · Cytokine · doi:10.1016/s1043-4666(03)00123-6 · Cited by 19 · see citing works
TGF‐β Down‐regulates Apolipoprotein M Expression through the TAK‐1‐JNK‐c‐Jun Pathway in HepG2 Cells
Ren, K., Mo, Z., Liu, X., Tang, Z., Jiang, Y., Peng, X., Zhang, Q., Shi, J., & Yi, G. (2016) · Lipids · doi:10.1007/s11745-016-4227-9 · Cited by 18 · see citing works
The Bone Marrow-Mediated Protection of Myeloproliferative Neoplastic Cells to Vorinostat and Ruxolitinib Relies on the Activation of JNK and PI3K Signalling Pathways
Cardoso, B. A., Belo, H., Barata, J. T., & Almeida, A. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143897 · Cited by 17 · see citing works
Tumor necrosis factor receptor‐associated factor 6 mediated the promotion of salivary adenoid cystic carcinoma progression through Smad‐p38‐ JNK signaling pathway induced by TGF ‐β
Liang, Y., Jiao, J., Liang, L., Zhang, J., Lu, Y. J., Xie, H., Liang, Q., Wan, D., Duan, L., Wu, Y., et al. (2018) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.12709 · Cited by 16 · see citing works
Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells
Deng, H., Zhang, J., Yoon, T., Song, D., Li, D.-D., & Lin, A. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.11.011 · Cited by 15 · see citing works
Two different specific JNK activators are required to trigger apoptosis or compensatory proliferation in response to Rbf1 in Drosophila
Clavier, A., Rincheval‐Arnold, A., Baillet, A., Mignotte, B., & Guénal, I. (2016) · Cell Cycle · doi:10.1080/15384101.2015.1100776 · Cited by 15 · see citing works
Compensatory role of Neuroglobin in nervous and non-nervous cancer cells in response to the nutrient deprivation
Fiocchetti, M., Cipolletti, M., & Marino, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0189179 · Cited by 15 · see citing works
c-Jun N-terminal kinase 1 defective CD4+CD25+FoxP3+ cells prolong islet allograft survival in diabetic mice
Tripathi, D., Cheekatla, S. S., Paidipally, P., Radhakrishnan, R. K., Welch, E., Thandi, R. S., Tvinnereim, A., & Vankayalapati, R. (2018) · Scientific Reports · doi:10.1038/s41598-018-21477-9 · Cited by 15 · see citing works
A Tumor Cell-Intrinsic Yin-Yang Determining Immune Evasion
Horton, B. L., & Spranger, S. (2018) · Immunity · doi:10.1016/j.immuni.2018.07.001 · Cited by 13 · see citing works
Regulation of compensatory β-cell proliferation by inter-organ networks from the liver to pancreatic β-cells
Imai, J. (2018) · Endocrine Journal · doi:10.1507/endocrj.ej18-0241 · Cited by 10 · see citing works
37LRP induces invasion in hypoxic lung adenocarcinoma cancer cells A549 through the JNK/ERK/c-Jun signaling cascade
Zhou, Y., Wang, Y., Zhao, Z., Wang, Y., Zhang, N., Zhang, H., & Liu, L. (2017) · Tumor Biology · doi:10.1177/1010428317701655 · Cited by 8 · see citing works

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The JAK/STAT signaling pathway: from bench to clinic
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Antitumor Effects of Carvacrol and Thymol: A Systematic Review
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Two-Faced: Roles of JNK Signalling During Tumourigenesis in the Drosophila Model
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An update on T-2 toxin and its modified forms: metabolism, immunotoxicity mechanism, and human exposure assessment
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JNK3 as Therapeutic Target and Biomarker in Neurodegenerative and Neurodevelopmental Brain Diseases
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RHOV promotes lung adenocarcinoma cell growth and metastasis through JNK/c-Jun pathway
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A risk signature with four autophagy‐related genes for predicting survival of glioblastoma multiforme
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Authors: Wu, Q., Wu, W., Fu, B., Shi, L., Wang, X., & Kuca, K.
Affiliations: Nanjing Agricultural University (CN)
Harvard University (US)
University of Manchester (GB)
Huazhong Agricultural University (CN)
Department of Chemistry Faculty of Science, University of Hradec Kralove Hradec Kralove Czech Republic
Corresponding author: Wang, Xu
ORCID: Wu, Qinghua
Wu, Wenda
Fu, Bishi
Wang, Xu
Kuca, Kamil
Venue: Medicinal Research Reviews
Publisher: Wiley
Published: 2019-03-25
Volume: 39
Issue: 6
Pages: 2082-2104
ISSN: 0198-6325 (ISSN-L)
1098-1128
DOI: 10.1002/med.21574
OpenAlex: W2923315793
Cited by: 322
References: 146
Citations by year: 2026: 22 · 2025: 51 · 2024: 68 · 2023: 42 · 2022: 56 · 2021: 43 · 2020: 29 · 2019: 11
FWCI: 3.40
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Medicinal Research Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (31572575, 31602114)
China Postdoctoral Science Foundation (2016T90477)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
Keywords: JNK signaling, c-Jun N-terminal kinase, tumor cell survival, apoptosis, NF-κB, JAK/STAT signaling, autophagy, chemoresistance, immune evasion, TGF-beta, Toll-like receptors, interferon-gamma, JNK1, JNK2, carcinogenesis, cell proliferation
MeSH terms: Animals, Autophagy, Cell Survival, Humans, Neoplasms, Drug Resistance, Neoplasm, MAP Kinase Signaling System, JNK Mitogen-Activated Protein Kinases

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JNK signaling in cancer cell survival

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