The DOI matches its Crossref record; 138 of the 138 references it cites were found in a registry or an index.
Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention
Open accessAbstract
The world's population aging progression renders age‐related neurodegenerative diseases to be one of the biggest unsolved problems of modern society. Despite the progress in studying the development of pathology, finding ways for modifying neurodegenerative disorders remains a high priority. One common feature of neurodegenerative diseases is mitochondrial dysfunction and overproduction of reactive oxygen species, resulting in oxidative stress. Although lipid peroxidation is one of the markers for oxidative stress, it also plays an important role in cell physiology, including activation of phospholipases and stimulation of signaling cascades. Excessive lipid peroxidation is a hallmark for most neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and many other neurological conditions. The products of lipid peroxidation have been shown to be the trigger for necrotic, apoptotic, and more specifically for oxidative stress‐related, that is, ferroptosis and neuronal cell death. Here we discuss the involvement of lipid peroxidation in the mechanism of neuronal loss and some novel therapeutic directions to oppose it.
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1 retracted
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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
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Cited by
RONS and Oxidative Stress: An Overview of Basic Concepts
Aranda-Rivera, A. K., Cruz-Gregorio, A., Arancibia-Hernández, Y. L., Hernández-Cruz, E. Y., & Pedraza-Chaverri, J. (2022) · Oxygen · doi:10.3390/oxygen2040030 · Cited by 384
Interaction of Mitochondrial Calcium and ROS in Neurodegeneration
Baev, A. Y., Vinokurov, A. Y., Novikova, I. N., Dremin, V. V., Potapova, E. V., & Abramov, A. Y. (2022) · Cells · doi:10.3390/cells11040706 · Cited by 162
Self-citationNew hope for Parkinson’s disease treatment: Targeting gut microbiota
Fan, H., Sheng, S., & Zhang, F. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13916 · Cited by 66
Wei, M., Bao, G., Li, S., Yang, Z., Cheng, C., & Le, W. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114333 · Cited by 55
Metadata
- Authors
- Angelova, P. R., Esteras, N., & Abramov, A. Y.
- Venue
- Medicinal Research Reviews
- Publisher
- Wiley
- Published
- 2020-07-13
- Volume
- 41
- Issue
- 2
- Pages
- 770-784
- ISSN
- 0198-6325 (ISSN-L)
- 1098-1128
- OpenAlex
- W3043203703
- Cited by
- 287
- References
- 138
- FWCI
- 14.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Angelova, P. R., Esteras, N., & Abramov, A. Y. (2021). Mitochondria and lipid peroxidation in the mechanism of neurodegeneration: Finding ways for prevention. Medicinal Research Reviews. https://doi.org/10.1002/med.21712
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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