Cited by 66Parkinson's Disease Mechanisms and TreatmentsGut microbiota and healthGastrointestinal motility and disorders

New hope for Parkinson’s disease treatment: Targeting gut microbiota

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Fan, Hong‐Xia, Sheng, Shuo, Zhang, Feng·2022·CNS Neuroscience & Therapeutics

Abstract

There might be more than 10 million confirmed cases of Parkinson's disease (PD) worldwide by 2040. However, the pathogenesis of PD is still unclear. Host health is closely related to gut microbiota, which are affected by factors such as age, diet, and exercise. Recent studies have found that gut microbiota may play key roles in the progression of a wide range of diseases, including PD. Changes in the abundance of gut bacteria, such as Helicobacter pylori, Enterococcus faecalis, and Desulfovibrio, might be involved in PD pathogenesis or interfere with PD therapy. Gut microbiota and the distal brain achieve action on each other through a gut‐brain axis composed of the nervous system, endocrine system, and immune system. Here, this review focused on the current understanding of the connection between Parkinson's disease and gut microbiota, to provide potential therapeutic targets for PD.

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Authors
Fan, H., Sheng, S., & Zhang, F.
Affiliations
  • Laboratory Animal Center and Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education and Key Laboratory of Basic Pharmacology of Guizhou Province Zunyi Medical University Zunyi Guizhou China
  • Zunyi Medical University (CN)
Corresponding author
Zhang, Feng
Venue
CNS Neuroscience & Therapeutics
Publisher
Wiley
Published
2022-07-13
Volume
28
Issue
11
Pages
1675-1688
ISSN
  • 1755-5930 (ISSN-L)
  • 1755-5949
OpenAlex
W4285086539
Cited by
66
References
198
Citations by year
2026: 14 · 2025: 13 · 2024: 22 · 2023: 13 · 2022: 4
FWCI
1.88
Type
journal article
Language
en
Open access
Locations
  • CNS Neuroscience & Therapeutics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (82160690)
  • Guizhou Science and Technology Department (ZK[2021]‐014, [2018]5772‐036 and [2020]‐012)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
Parkinson's disease, gut microbiota, gut-brain axis, Helicobacter pylori, Enterococcus faecalis, Desulfovibrio, therapeutic target, neurodegeneration
MeSH terms
Gastrointestinal Microbiome, Brain, Humans, Parkinson Disease

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