New hope for Parkinson’s disease treatment: Targeting gut microbiota
Open accessAbstract
There might be more than 10 million confirmed cases of Parkinson's disease (PD) worldwide by 2040. However, the pathogenesis of PD is still unclear. Host health is closely related to gut microbiota, which are affected by factors such as age, diet, and exercise. Recent studies have found that gut microbiota may play key roles in the progression of a wide range of diseases, including PD. Changes in the abundance of gut bacteria, such as Helicobacter pylori, Enterococcus faecalis, and Desulfovibrio, might be involved in PD pathogenesis or interfere with PD therapy. Gut microbiota and the distal brain achieve action on each other through a gut‐brain axis composed of the nervous system, endocrine system, and immune system. Here, this review focused on the current understanding of the connection between Parkinson's disease and gut microbiota, to provide potential therapeutic targets for PD.
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Altering the gut microbiota composition is a viable target for diagnosing and treating Parkinson's disease.
“Altering the gut microbiota composition is a viable target for diagnosing and treating PD [31,32].”
From Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson’s Disease (2023) · cites this paper as [31]
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Guo, T.-T., Zhang, Z., Sun, Y., Zhu, R.-Y., Wang, F.-X., Ma, L.-J., Jiang, L., & Liu, H.-D. (2023) · Nutrients · doi:10.3390/nu15040930 · Cited by 82 · see citing works
- Authors
- Fan, H., Sheng, S., & Zhang, F.
- Affiliations
- Laboratory Animal Center and Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education and Key Laboratory of Basic Pharmacology of Guizhou Province Zunyi Medical University Zunyi Guizhou China
- Zunyi Medical University (CN)
- Corresponding author
- Zhang, Feng
- ORCID
- Zhang, Feng
- Venue
- CNS Neuroscience & Therapeutics
- Publisher
- Wiley
- Published
- 2022-07-13
- Volume
- 28
- Issue
- 11
- Pages
- 1675-1688
- ISSN
- 1755-5930 (ISSN-L)
- 1755-5949
- PMC
- PMC9532916
- OpenAlex
- W4285086539
- Cited by
- 66
- References
- 198
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 22 · 2023: 13 · 2022: 4
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- CNS Neuroscience & Therapeutics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (82160690)
- Guizhou Science and Technology Department (ZK[2021]‐014, [2018]5772‐036 and [2020]‐012)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Parkinson's disease, gut microbiota, gut-brain axis, Helicobacter pylori, Enterococcus faecalis, Desulfovibrio, therapeutic target, neurodegeneration
- MeSH terms
- Gastrointestinal Microbiome, Brain, Humans, Parkinson Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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