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Cited by 23Cytokine Signaling Pathways and InteractionsBioactive natural compoundsNatural Compounds in Disease Treatment

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Natural products as IL‐6 inhibitors for inflammatory diseases: Synthetic and SAR perspective

Harmalkar, Dipesh S., Sivaraman, Aneesh, Nada, Hossam, Lee, Joohan, Kang, Hyeseul, Choi, Yongseok, Lee, Kyeong·2024·Medicinal Research Reviews
DOI 10.1002/med.22022
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Abstract

Interleukin‐6 (IL‐6), a pleiotropic cytokine, plays a pivotal role in the pathophysiology of various diseases including diabetes, atherosclerosis, Alzheimer's disease, multiple myeloma, rheumatoid arthritis, and prostate cancer. The signaling pathways associated with IL‐6 offer promising targets for therapeutic interventions in inflammatory diseases and IL‐6‐dependent tumors. Although certain anti‐IL‐6 monoclonal antibodies are currently employed clinically, their usage is hampered by drawbacks such as high cost and potential immunogenicity, limiting their application. Thus, the imperative arises to develop novel small non‐peptide molecules acting as IL‐6 inhibitors. Various natural products derived from diverse sources have been investigated for their potential to inhibit IL‐6 activity. Nevertheless, these natural products remain inadequately explored in terms of their structure‐activity relationships. In response, our review aims to provide syntheses and structure activity perspective of natural IL‐6 inhibitors. The comprehensive amalgamation of information presented in this review holds the potential to serve as a foundation for forthcoming research endeavors by medicinal chemists, facilitating the design of innovative IL‐6 inhibitors to address the complexities of inflammatory diseases.

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Metadata

Authors
Harmalkar, D. S., Sivaraman, A., Nada, H., Lee, J., Kang, H., Choi, Y., & Lee, K.
Affiliations
  • Korea University (KR)
  • Dongguk University (KR)
Corresponding author
  • Choi, Yongseok
  • Lee, Kyeong
ORCID
Venue
Medicinal Research Reviews
Publisher
Wiley
Published
2024-02-02
Volume
44
Issue
4
Pages
1683-1726
ISSN
  • 0198-6325 (ISSN-L)
  • 1098-1128
DOI
10.1002/med.22022
OpenAlex
W4391484807
Cited by
23
References
1
Citations by year
2026: 7 · 2025: 8 · 2024: 8
FWCI
1.22
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Medicinal Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Research Foundation of Korea (NRF 2018R1A5A2023127, 2023R1A2C3004599)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
  • Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Keywords
interleukin-6, IL-6 inhibitors, natural products, structure-activity relationship, small molecule inhibitors, anti-inflammatory agents, inflammatory diseases, IL-6 signaling, medicinal chemistry
MeSH terms
Interleukin-6 Inhibitors, Animals, Biological Products, Humans, Inflammation, Structure-Activity Relationship, Interleukin-6

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