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Interleukin-6 and Its Receptor: A Paradigm for Cytokines

Kishimoto, Tadamitsu, Akira, Shizuo, Taga, Tetsuya·1992·Science
DOI 10.1126/science.1411569
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Abstract

Many cytokines and cytokine receptors involved in the regulation of hematopoiesis, immune responses, and inflammation have been identified and characterized at the molecular level. Several characteristic features of cytokines, such as pleiotropy and redundancy, are now more clearly understood on the basis of their molecular structures. Accumulating evidence has demonstrated an intimate link between cytokines and various diseases such as allergy, autoimmune diseases, and cancer. The pathogenesis of these diseases and therapies to treat them will be discussed based on insights derived from cytokine research.

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Crossref · 10.1126/science.1411569

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  • The IL-6 signaling cascade is initiated by binding of IL-6 to IL-6R and a second transmembrane protein, gp130, which serves as a signal transducer of IL-6.

    “The IL-6 signaling cascade is initiated by binding of IL-6 to IL-6R and a second transmembrane protein, gp130, which serves as a signal transducer of IL-6 (Kishimoto et al., 1992”

    From Targeting Interleukin-6 Signaling in Clinic (2019) · cites this paper as Kishimoto et al., 1992

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Metadata

Authors
Kishimoto, T., Akira, S., & Taga, T.
Affiliations
Department of Internal Medicine Ill, Osaka University Medical School Osaka City 553, and Institute for Molecular and Cellular Biology, Osaka University, Suita City 565, Japan
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1992-10-23
Volume
258
Issue
5082
Pages
593-597
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.1411569
Cited by
665
References
2
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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