Cited by 42Advanced Glycation End Products researchBiochemical Acid Research StudiesFolate and B Vitamins Research

Preventing cell death induced by carbonyl stress, oxidative stress or mitochondrial toxins with vitamin B anti-AGE agents

Mehta, Rhea, Shangari, Nandita, O'Brien, Peter J.·2008·Molecular Nutrition & Food Research

Abstract

Carbonyls generated by autoxidation of carbohydrates or lipid peroxidation have been implicated in advanced glycation end product (AGE) formation in tissues adversely affected by diabetes complications. Tissue AGE and associated pathology have been decreased by vitamin B(1)/B(6) in trials involving diabetic animal models. To understand the molecular cytoprotective mechanisms involved, the effects of B(1)/B(6) vitamers against cytotoxicity induced by AGE/advanced lipid end product (ALE) carbonyl precursors (glyoxal/acrolein) have been compared to cytotoxicity induced by oxidative stress (hydroperoxide) or mitochondrial toxins (cyanide/copper). Thiamin was found to be best at preventing cell death induced by carbonyl stress and mitochondrial toxins but not oxidative stress cell death suggesting that thiamin pyrophosphate restored pyruvate and alpha-ketoglutarate dehydrogenases inhibited by mitochondrial toxicity. However, B(6) vitamers were most effective at preventing oxidative stress or lipid peroxidation cytotoxicity suggesting that pyridoxal or pyridoxal phosphate were antioxidants and/or Fe/Cu chelators. A therapeutic vitamin cocktail could provide maximal prevention against carbonyl stress toxicity associated with diabetic complications.

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Crossref · 10.1002/mnfr.200600190

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45 of 45 references verified0 citation errors · 0 not checkable

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Authors
Mehta, R., Shangari, N., & O'Brien, P. J.
Affiliations
University of Toronto (CA)
Venue
Molecular Nutrition & Food Research
Publisher
Wiley
Published
2008-03
Volume
52
Issue
3
Pages
379-385
ISSN
  • 1613-4125 (ISSN-L)
  • 1613-4133
OpenAlex
W2116883290
Cited by
42
References
45
Citations by year
2025: 1 · 2023: 1 · 2021: 4 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 6 · 2013: 4 · 2012: 1
FWCI
2.19
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Nutrition & Food Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
  • Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
Keywords
advanced glycation end products, carbonyl stress, thiamine, vitamin B6, pyridoxal phosphate, oxidative stress, mitochondrial toxins, cyanide, copper, lipid peroxidation, glyoxal, acrolein, cell death prevention, pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, diabetes complications, antioxidants
MeSH terms
Acrolein, Aldehydes, Animals, Cyanides, Glyoxal, Male, Microsomes, Liver, Mitochondria, Thiamine, Vitamin B Complex, Lipid Peroxidation, Cell Death, Glycation End Products, Advanced, Rats, Sprague-Dawley, Reactive Oxygen Species, Oxidative Stress, Copper Sulfate, Hepatocytes, Vitamin B 6, Rats

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