The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice
Open accessAbstract
Epidemiology supports the important role of nutrition in prostate cancer (PCa) prevention. Pomegranate juice (PJ) exerts protective effects against PCa, mainly attributed to PJ ellagitannins (ETs). Our aim was to assess whether ETs or their metabolites ellagic acid and urolithins reach the human prostate upon consumption of ET-rich foods and to evaluate the effect on the expression of three proliferation biomarkers. Sixty-three patients with BPH or PCa were divided into controls and consumers of walnuts (35 g walnuts/day) or pomegranate (200 mL PJ/day) for 3 days before surgery. Independently of the ETs source, the main metabolite detected was urolithin A glucuronide, (3,8-dihydroxy-6H-dibenzo[b,d]pyran-6-one glucuronide) (up to 2 ng/g) together with the traces of urolithin B glucuronide, (3-hydroxy-6H-dibenzo[b,d]pyran-6-one glucuronide) and dimethyl ellagic acid. The small number of prostates containing metabolites was likely caused by clearance of the compounds during the fasting. This was corroborated in a parallel rat study and thus the presence of higher quantities of metabolites at earlier time points cannot be discarded. No apparent changes in the expression of CDKN1A, MKi-67 or c-Myc were found after consumption of the walnuts or PJ. Our results suggest that urolithin glucuronides and dimethyl ellagic acid may be the molecules responsible for the beneficial effects of PJ against PCa.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The concentration of serum urolithins can reach up to micromolar levels without displaying toxicity in certain populations.132,134,138,144,145”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [138]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Lost in Transcription: p21 Repression, Mechanisms, and Consequences
Gartel, A. L., & Radhakrishnan, S. K. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3995 · Cited by 841
Pantuck, A. J., Leppert, J. T., Zomorodian, N., Aronson, W. J., Hong, J., Barnard, R. J., Seeram, N. P., Liker, H. R., Wang, H., Elashoff, R. M., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2290 · Cited by 465
Larrosa, M., Tomás-Barberán, F. A., & Espı́n, J. C. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.09.004 · Cited by 461
Self-citationCerdá, B., Tomás-Barberán, F. A., & Espı́n, J. C. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf049144d · Cited by 448
Self-citationInternational epidemiology of prostate cancer: Geographical distribution and secular trends
Baade, P. D., Youlden, D. R., & Krnjacki, L. J. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700511 · Cited by 446
Cerd�, B., Esp�n, J. C., Parra, S., Mart�nez, P., & Tom�s-Barber�n, F. A. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-0461-7 · Cited by 435
Self-citationRole of Diet in Prostate Cancer Development and Progression
Chan, J. M., Gann, P. H., & Giovannucci, E. L. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.03.1492 · Cited by 414
Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer
Malik, A., Afaq, F., Sarfaraz, S., Adhami, V. M., Syed, D. N., & Mukhtar, H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505870102 · Cited by 401
Espín, J. C., González-Barrio, R., Cerdá, B., López-Bote, C., Rey, A. I., & Tomás-Barberán, F. A. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0723864 · Cited by 352
Self-citationCerdá, B., Periago, P., Espín, J. C., & Tomás-Barberán, F. A. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf050384i · Cited by 301
Self-citationSeeram, N. P., Aronson, W. J., Zhang, Y., Henning, S. M., Moro, A., Lee, R., Sartippour, M. R., Harris, D. M., Rettig, M. B., Suchard, M. A., et al. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071303g · Cited by 293
Analysis of ellagitannins and conjugates of ellagic acid and quercetin in raspberry fruits by LC–MSn
Mullen, W., Yokota, T., Lean, M. E. J., & Crozier, A. (2003) · Phytochemistry · doi:10.1016/s0031-9422(03)00281-4 · Cited by 265
Larrosa, M., González‐Sarrías, A., García‐Conesa, M., Tomás-Barberán, F. A., & Espı́n, J. C. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0527403 · Cited by 261
Self-citationKresty, L. A., Morse, M. A., Morgan, C., Carlton, P. S., Lu, J., Gupta, A. K., Blackwood, M., & Stoner, G. D. (2001) · PubMed · Cited by 249
Albrecht, M., Jiang, W. G., Kumi-Diaka, J. K., Lansky, E. S., Gommersall, L. M., Patel, A. N., Mansel, R. E., Neéman, I., Geldof, A. A., & Campbell, M. J. (2004) · Journal of Medicinal Food · doi:10.1089/jmf.2004.7.274 · Cited by 242
Myc confers androgen-independent prostate cancer cell growth
Bernard, D., Pourtier, A., Gil, J., & Beach, D. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319035 · Cited by 235
González‐Sarrías, A., Espı́n, J. C., Tomás-Barberán, F. A., & García‐Conesa, M. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800150 · Cited by 158
Self-citationJemal, A., Ward, E., Wu, X., Martin, H. J., McLaughlin, C. C., & Thun, M. J. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-04-0522 · Cited by 156
Pomegranate derived products for cancer chemoprevention
Syed, D. N., Afaq, F., & Mukhtar, H. (2007) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2007.05.004 · Cited by 144
Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis
Luo, J., Dunn, T. A., Ewing, C. M., Sauvageot, J., Chen, Y., Trent, J. M., & Isaacs, W. B. (2002) · The Prostate · doi:10.1002/pros.10087 · Cited by 138
Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo
Sartippour, M. R., Seeram, N. P., Rao, J. Y., Moro, A., Harris, D., Henning, S. M., Firouzi, A., Rettig, M. B., Aronson, W. J., Pantuck, A. J., et al. (2008) · International Journal of Oncology · doi:10.3892/ijo.32.2.475 · Cited by 121
Ki-67 and PCNA expression in prostate cancer and benign prostatic hyperplasia
Zhong, W., Peng, J., Hui-chan, H., Wu, D., Han, Z., Bi, X., & Dai, Q.-S. (2008) · Clinical and investigative medicine · doi:10.25011/cim.v31i1.3136 · Cited by 104
The effect of walnut intake on factors related to prostate and vascular health in older men
Spaccarotella, K., Kris‐Etherton, P. M., Stone, W. L., Bagshaw, D. M., Fishell, V. K., West, S. G., Lawrence, F., & Hartman, T. J. (2008) · Nutrition Journal · doi:10.1186/1475-2891-7-13 · Cited by 93
Expression and copy number analysis of TRPS1, EIF3S3 and MYC genes in breast and prostate cancer
Savinainen, K., Linja, M. J., Saramäki, O. R., Tammela, T. L. J., Chang, G. T. G., Brinkmann, A. O., & Visakorpi, T. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601648 · Cited by 84
Prostate cancer and vegetable consumption
Chan, R., Lok, K. Y. W., & Woo, J. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800113 · Cited by 76
INTEGRATIVE BIOLOGY OF PROSTATE CANCER PROGRESSION
Tomlins, S. A., Rubin, M. A., & Chinnaiyan, A. M. (2006) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.1.110304.100047 · Cited by 66
Correlations of dietary patterns with prostate health
Stacewicz‐Sapuntzakis, M., Borthakur, G., Burns, J. L., & Bowen, P. E. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600296 · Cited by 63
Downregulation of both p21/Cip1 and p27/Kip1 produces a more aggressive prostate cancer phenotype
Roy, S., Singh, R. P., Agarwal, C., Siriwardana, S., Sclafani, R. A., & Agarwal, R. (2008) · Cell Cycle · doi:10.4161/cc.7.12.6024 · Cited by 53
Induction of Cell Cycle Arrest in Prostate Cancer Cells by the Dietary Compound Isoliquiritigenin
Lee, Y. M., Lim, D. Y., Choi, H. J., Jung, J. I., Chung, W., & Park, J. H. Y. (2009) · Journal of Medicinal Food · doi:10.1089/jmf.2008.0039 · Cited by 53
Prevention of Hormone-Related Cancers: Prostate Cancer
Parnes, H. L., Thompson, I. M., & Ford, L. G. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.08.027 · Cited by 49
Apoptosis-related gene expression in benign prostatic hyperplasia and prostate carcinoma.
Iacopino, F., Angelucci, C., Lama, G., Zelano, G., Torre, G. L., D’Addessi, A., Giovannini, C., Bertaccini, A., Pavone‐Macaluso, M., Martorana, G., et al. (2006) · PubMed · Cited by 33
Rigaud, J., Tiguert, R., Decobert, M., Hovington, H., Latulippe, É., Laverdière, J., LaRue, H., Lacombe, L., & Fradet, Y. (2003) · The Prostate · doi:10.1002/pros.10329 · Cited by 31
Nagy, B., Szendrői, A., & Romics, I. (2008) · Pathology & Oncology Research · doi:10.1007/s12253-008-9077-1 · Cited by 31
Royuela, M., Arenas, M. I., de Bethencourt, F. R., Sánchez‐Chapado, M., Fraile, B., & Paniagua, R. (2001) · PubMed · Cited by 30
Nikoleishvili, D., Pertia, A., Trsintsadze, O., Gogokhia, N., Managadze, L., & Chkhotua, A. B. (2008) · International Urology and Nephrology · doi:10.1007/s11255-008-9350-y · Cited by 26
Quantitative real-time RT-PCR of CD24 mRNA in the detection of prostate cancer
Schostak, M., Krause, H., Miller, K., Schrader, M., Weikert, S., Christoph, F., Kempkensteffen, C., & Köllermann, J. W. (2006) · BMC Urology · doi:10.1186/1471-2490-6-7 · Cited by 23
Molecular markers in the diagnosis of prostate cancer
van der Poel, H. G. (2006) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2006.07.003 · Cited by 23
Lack of Effect of Walnuts on Serum Levels of Prostate Specific Antigen: A Brief Report
Simon, J. A., Tanzman, J. S., & Sabaté, J. (2007) · Journal of the American College of Nutrition · doi:10.1080/07315724.2007.10719617 · Cited by 13
Angelucci, C., Iacopino, F., Lama, G., Zelano, G., Gianesini, G., Sica, G., & Bono, A. V. (2005) · PubMed · Cited by 10
Faulks (2000) · doi:10.1002/(sici)1097-0010(20000515)80:7
Research works printed but not linked: 1
- Clifford M. N., 2000, Elagitannins‐nature, occurrence and dietary burden, J. Sci. Food Agric., 80, 118
Cited by
Sorted by citations
Del Rio, D., Rodriguez-Mateos, A., Spencer, J. P. E., Tognolini, M., Borges, G., & Crozier, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4581 · Cited by 2,601
Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., Williams, E. G., Jha, P., Lo Sasso, G., Huzard, D., et al. (2016) · Nature Medicine · doi:10.1038/nm.4132 · Cited by 1,105
The strawberry: Composition, nutritional quality, and impact on human health
Giampieri, F., Tulipani, S., Álvarez-Suárez, J. M., Quiles, J. L., Mezzetti, B., & Battino, M. A. (2011) · Nutrition · doi:10.1016/j.nut.2011.08.009 · Cited by 1,067
Regulation of Intestinal Barrier Function by Microbial Metabolites
Ghosh, S., Whitley, C. S., Haribabu, B., & Jala, V. R. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.02.007 · Cited by 835
Landete, J. M. (2011) · Food Research International · doi:10.1016/j.foodres.2011.04.027 · Cited by 733
Metadata
- Authors
- González‐Sarrías, A., Giménez‐Bastida, J. A., García‐Conesa, M. T., Gómez‐Sánchez, M. B., García‐Talavera, N. V., Gil‐Izquierdo, A., Sánchez‐Álvarez, C., Fontana‐Compiano, L. O., Morga‐Egea, J. P., Pastor‐Quirante, F. A., Martínez‐Díaz, F., Tomás‐Barberán, F. A., & Espín, J. C.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Hospital Reina Sofía de Murcia (ES)
- ORCID
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2010-03
- Volume
- 54
- Issue
- 3
- Pages
- 311-322
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W2130994151
- Cited by
- 212
- References
- 40
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 14 · 2023: 10 · 2022: 17 · 2021: 16 · 2020: 16 · 2019: 12 · 2018: 16 · 2017: 17 · 2016: 14 · 2015: 15 · 2014: 11 · 2013: 16 · 2012: 7
- FWCI
- 5.49
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Molecular Nutrition & Food Research (publishedVersion)
- PubMed (publishedVersion)
- Hispana (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, other-oa)
- Funders
- Ministerio de Ciencia e Innovación (CSD2007-00063)
- Consejo Superior de Investigaciones Científicas (CSD2007-00063)
- Instituto de Salud Carlos III (CSD2007-00063)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
- Keywords
- urolithins, ellagitannins, ellagic acid, gut microbiota metabolites, pomegranate juice, Juglans regia, prostate cancer prevention, benign prostatic hyperplasia, cell proliferation markers, p21, Ki-67, c-Myc, dietary bioactive compounds
- MeSH terms
- Aged, Animals, Beverages, Coumarins, Ellagic Acid, Fruit, Humans, Intestines, Male, Middle Aged, Nuclear Proteins, Plant Extracts, Prostate, Prostatic Hyperplasia, Prostatic Neoplasms, RNA, Messenger, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins c-myc, Rats, Sprague-Dawley, Glucuronides, Lythraceae, Juglans, Hydrolyzable Tannins, Intracellular Signaling Peptides and Proteins, Cyclin-Dependent Kinase Inhibitor p21, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
