Iberian pig as a model to clarify obscure points in the bioavailability and metabolism of ellagitannins in humans

Antioxidant Activity of Pomegranate Juice and Its Relationship with Phenolic Composition and Processing

Gil, M. I., Tomás-Barberán, F. A., Hess-Pierce, B. M., Holcroft, D. M., & Kader, A. A. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf000404a · Cited by 2,365 · see citing works

Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E–deficient mice

Aviram, M., Dornfeld, L., Rosenblat, M., Volkova, N., Kaplan, M., Coleman, R., Hayek, T., Presser, D., & Fuhrman, B. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.5.1062 · Cited by 866 · see citing works

Tissue Distribution of Quercetin in Rats and Pigs

de Boer, V. C. J., Dihal, A. A., van der Woude, H., Arts, I. C. W., Wolffram, S., Alink, G. M., Rietjens, I. M. C. M., Keijer, J., & Hollman, P. C. H. (2005) · Journal of Nutrition · doi:10.1093/jn/135.7.1718 · Cited by 519 · see citing works

Pomegranate Juice Ellagitannin Metabolites Are Present in Human Plasma and Some Persist in Urine for Up to 48 Hours

Seeram, N. P., Henning, S. M., Zhang, Y., Suchard, M. A., Li, Z., & Heber, D. (2006) · Journal of Nutrition · doi:10.1093/jn/136.10.2481 · Cited by 477 · see citing works

The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway

Larrosa, M., Tomás-Barberán, F. A., & Espı́n, J. C. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.09.004 · Cited by 461 · see citing works

Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice

Seeram, N. P., Lee, R., & Heber, D. (2004) · Clinica Chimica Acta · doi:10.1016/j.cccn.2004.04.029 · Cited by 454 · see citing works

Metabolism of Antioxidant and Chemopreventive Ellagitannins from Strawberries, Raspberries, Walnuts, and Oak-Aged Wine in Humans: Identification of Biomarkers and Individual Variability

Cerdá, B., Tomás-Barberán, F. A., & Espı́n, J. C. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf049144d · Cited by 448 · see citing works

The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6H-dibenzopyran-6-one derivatives by the colonic microflora of healthy humans

Cerd�, B., Esp�n, J. C., Parra, S., Mart�nez, P., & Tom�s-Barber�n, F. A. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-0461-7 · Cited by 435 · see citing works

Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice

Cerd�, B., Llorach, R., Cer�n, J. J., Espı́n, J. C., & Tomás-Barberán, F. A. (2003) · European Journal of Nutrition · doi:10.1007/s00394-003-0396-4 · Cited by 384 · see citing works

Antioxidative polyphenols from walnuts (Juglans regia L.)

Fukuda, T., Ito, H., & Yoshida, T. (2003) · Phytochemistry · doi:10.1016/s0031-9422(03)00333-9 · Cited by 366 · see citing works

Absorption, Metabolism, and Antioxidant Effects of Pomegranate (Punica granatum L.) Polyphenols after Ingestion of a Standardized Extract in Healthy Human Volunteers

Mertens‐Talcott, S. U., Jilma‐Stohlawetz, P., Rios, J., Hingorani, L., & Derendorf, H. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf061674h · Cited by 353 · see citing works

Effect of Processing and Storage on the Antioxidant Ellagic Acid Derivatives and Flavonoids of Red Raspberry (Rubus idaeus) Jams

Zafrilla, P., Ferreres, F., & Tomás-Barberán, F. A. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010192x · Cited by 315 · see citing works

Identification of urolithin a as a metabolite produced by human colon microflora from ellagic acid and related compounds

Cerdá, B., Periago, P., Espín, J. C., & Tomás-Barberán, F. A. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf050384i · Cited by 301 · see citing works

Repeated Oral Administration of High Doses of the Pomegranate Ellagitannin Punicalagin to Rats for 37 Days Is Not Toxic

Cerdá, B., Cerón, J. M. C., Tomás-Barberán, F. A., et al. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020842c · Cited by 297 · see citing works

Urolithins, Ellagic Acid-Derived Metabolites Produced by Human Colonic Microflora, Exhibit Estrogenic and Antiestrogenic Activities

Larrosa, M., González‐Sarrías, A., García‐Conesa, M., Tomás-Barberán, F. A., & Espı́n, J. C. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0527403 · Cited by 261 · see citing works

Phenolic Compounds and Fatty Acids from Acorns (Quercus spp.), the Main Dietary Constituent of Free-Ranged Iberian Pigs

Cantos‐Villar, E., Espı́n, J. C., López-Bote, C. J., de la Hoz, L., Pereda, J. A. O., & Tomás-Barberán, F. A. (2003) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030216v · Cited by 207 · see citing works

Pharmacokinetics of Anthocyanins and Ellagic Acid in Healthy Volunteers Fed Freeze‐Dried Black Raspberries Daily for 7 Days

Stoner, G. D., Sardo, C. L., Apseloff, G., Mullet, D., Wargo, W. F., Pound, V., Singh, A., Sanders, J. H., Aziz, R. M., Casto, B. C., et al. (2005) · The Journal of Clinical Pharmacology · doi:10.1177/0091270005279636 · Cited by 164 · see citing works

Pomegranate juice supplementation in chronic obstructive pulmonary disease: a 5-week randomized, double-blind, placebo-controlled trial

Cerdá, B., Soto, C., Albaladejo, M. D., Martínez, P., Sánchez-Gascón, F., Tomás-Barberán, F. A., & Espı́n, J. C. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602309 · Cited by 130 · see citing works

Rapid Liquid Chromatography Tandem Mass Spectrometry Assay To Quantify Plasma (−)-Epicatechin Metabolites after Ingestion of a Standard Portion of Cocoa Beverage in Humans

Roura, E., Andrés‐Lacueva, C., Jáuregui, O., Badı́a, E., Estruch, R., Izquierdo-Pulido, M., & Lamuela-Raventós, R. M. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf050377u · Cited by 84 · see citing works

Molecular Mechanisms Involved in Chemoprevention of Black Raspberry Extracts: From Transcription Factors to Their Target Genes

Lu, H., Li, J., Zhang, D., Stoner, G. D., & Huang, C. (2006) · Nutrition and Cancer · doi:10.1207/s15327914nc5401_8 · Cited by 59 · see citing works

Hyaluronidase Inhibitory Active 6H-Dibenzo[b,d]pyran-6-ones from the Feces ofTrogopterus xanthipes

Jeong, S., Kim, N.-Y., Kim, D., et al. (2009) · Planta Medica · doi:10.1055/s-0029-1243114 · Cited by 38 · see citing works

Composition of subcutaneous fat from dry‐cured Iberian hams as influenced by pig feeding

Timon, M. L., Martín, L., Petrón, M. J., et al. (2001) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.1017 · Cited by 30 · see citing works

Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases

Del Rio, D., Rodriguez-Mateos, A., Spencer, J. P. E., Tognolini, M., Borges, G., & Crozier, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4581 · Cited by 2,601 · see citing works

Interaction between Phenolics and Gut Microbiota: Role in Human Health

Selma, M. V., Espín, J. C., & Tomás-Barberán, F. A. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf902107d · Cited by 1,324 · see citing works

Regulation of Intestinal Barrier Function by Microbial Metabolites

Ghosh, S., Whitley, C. S., Haribabu, B., & Jala, V. R. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.02.007 · Cited by 835 · see citing works

Biological significance of urolithins, the gut microbial ellagic Acid-derived metabolites: the evidence so far

Espín, J. C., Larrosa, M., García-Conesa, M. T., & Tomás-Barberán, F. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/270418 · Cited by 576 · see citing works

Urolithins, the rescue of “old” metabolites to understand a “new” concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status

Tomás‐Barberán, F. A., González‐Sarrías, A., García‐Villalba, R., Núñez‐Sánchez, M. A., Selma, M. V., García‐Conesa, M. T., & Espín, J. C. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500901 · Cited by 465 · see citing works

Effect of a Low Dose of Dietary Resveratrol on Colon Microbiota, Inflammation and Tissue Damage in a DSS-Induced Colitis Rat Model

Larrosa, M., Yañéz-Gascón, M. J., Selma, M. V., González-Sarrías, A., Toti, S., Cerón, J. J., Tomás-Barberán, F., Dolara, P., & Espín, J. C. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf803638d · Cited by 365 · see citing works

Description of urolithin production capacity from ellagic acid of two human intestinal Gordonibacter species

Selma, M. V., Beltrán, D., García-Villalba, R., Espín, J. C., & Tomás-Barberán, F. A. (2014) · Food Funct. · doi:10.1039/c4fo00092g · Cited by 304 · see citing works

Multitargeted therapy of cancer by ellagitannins

Heber, D. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.03.043 · Cited by 227 · see citing works

Pomegranate’s neuroprotective effects against Alzheimer’s disease are mediated by urolithins, its ellagitannin-gut microbial derived metabolites

Yuan, T., Ma, H., Liu, W., Niesen, D. B., Shah, N., Crews, R., Rose, K. N., Vattem, D. A., & Seeram, N. P. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00260 · Cited by 219 · see citing works

Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice

González‐Sarrías, A., Giménez‐Bastida, J. A., García‐Conesa, M. T., Gómez‐Sánchez, M. B., García‐Talavera, N. V., Gil‐Izquierdo, A., Sánchez‐Álvarez, C., Fontana‐Compiano, L. O., Morga‐Egea, J. P., Pastor‐Quirante, F. A., et al. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900152 · Cited by 212 · see citing works

Milk fatty acid composition, rumen microbial population, and animal performances in response to diets rich in linoleic acid supplemented with chestnut or quebracho tannins in dairy ewes

Buccioni, A., Pauselli, M., Viti, C., Minieri, S., Pallara, G., Roscini, V., Rapaccini, S., Marinucci, M. T., Lupi, P., Conte, G., et al. (2015) · Journal of Dairy Science · doi:10.3168/jds.2014-8651 · Cited by 164 · see citing works

Metabolic Fate of Ellagitannins: Implications for Health, and Research Perspectives for Innovative Functional Foods

Garcia-Muñoz, C., & Vaillant, F. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.644643 · Cited by 133 · see citing works

Probiotic Bacteria for Healthier Aging: Immunomodulation and Metabolism of Phytoestrogens

Landete, J. M., Gaya, P., Rodríguez, E., Langa, S., Peirotén, Á., Medina, M., & Arqués, J. L. (2017) · BioMed Research International · doi:10.1155/2017/5939818 · Cited by 76 · see citing works

Urolithin B, a Newly Identified Regulator of Skeletal Muscle Mass

Rodriguez, J., Pierre, N., Naslain, D., Bontemps, F., Ferreira, D., Priem, F., Deldicque, L., & Francaux, M. (2017) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12190 · Cited by 70 · see citing works

Pomegranate Extract Prevents Skeletal Muscle of Mice against Wasting Induced by Acute TNF-α Injection

Rodriguez, J., Caille, O., Ferreira, D., & Francaux, M. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600169 · Cited by 32 · see citing works

Tea Is a Significant Dietary Source of Ellagitannins and Ellagic Acid

Yang, X. M., & Tomás-Barberán, F. A. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b05010 · Cited by 68 · see citing works

Ellagitannins from Portuguese oak wood (Quercus pyrenaica Willd.) used in cooperage: influence of geographical origin, coarseness of the grain and toasting level

Jordão, A. M., Ricardo-Da-Silva, J. M., & Laureano, O. (2007) · Holzforschung · doi:10.1515/hf.2007.028 · Cited by 52 · see citing works

Bioavailability, Metabolism, and Bioactivity of Food Ellagic Acid and Related Polyphenols

Tomás-Barberán, F. A., García‐Conesa, M., Larrosa, M., et al. (2008) · doi:10.1002/9781444302400.ch11 · Cited by 14 · see citing works

Health-enhancing activity of ellagic acid and ellagitannin of selected species from the genus Rubus – Review

Kostryco, M., & Chwil, M. (2018) · Annales Horticulturae · doi:10.24326/ah.2018.2.1 · Cited by 1 · see citing works

Raspberry marc extracts increase antioxidative potential, ellagic acid, ellagitannin and anthocyanin concentrations in fruit purees

Bobinaitė, R., Viškelis, P., Bobinas, Č., Mieželienė, A., Alenčikienė, G., & Venskutonis, P. R. (2015) · LWT · doi:10.1016/j.lwt.2015.10.069 · Cited by 56 · see citing works