Antioxidant effectiveness of coffee extracts and selected constituents in cell‐free systems and human colon cell lines
Abstract
Scope: Epidemiological studies suggest that coffee can reduce the risk of degenerative diseases such as diabetes type 2, cardiovascular disease and cancer. These beneficial effects have partly been attributed to the antioxidant activity of coffee. We determined composition and antioxidant potential of differentially roasted coffee extracts and investigated the impact of selected original constituents and roast products. Methods and results: Parameters studied were direct antioxidant activity (trolox equivalent antioxidant capacity/oxygen radical absorbing capacity), cellular reactive oxygen species (ROS) level, DNA damage and protein expression of NAD(P)H: quinone oxidoreductase, γ‐glutamylcysteine ligase and glutathione reductase in HT‐29/Caco‐2 cells at 24‐h incubation. All extracts showed distinct direct antioxidant activity: medium roasts>light roast AB1 (caffeoylquinic acid (CQA)‐rich Arabica Brazil extract); dark roast AB2 (N‐methylpyridinium (NMP)‐rich Arabica Brazil extract), and diminished t‐butylhydroperoxide‐induced ROS level in HT‐29 cells (AB2>medium roasts>AB1). NAD(P)H:quinone oxidoreductase 1 expression and γ‐glutamylcysteine ligase expression were distinctly induced by AB1 and 5‐CQA, but not by AB2 and NMP. 5‐CQA and caffeic acid exhibited highest trolox equivalent antioxidant capacity/oxygen radical absorbing capacity values (5‐CQA: 1.3/3.5 mM and caffeic acid: 1.3/3.9 mM trolox); ROS level was distinctly diminished by 5‐CQA (≥3 μM), catechol (30 μM) and trigonelline (≥30 μM), whereas menadione‐induced DNA damage in Caco‐2 cells was reduced by NMP compounds (1–30 μM). Conclusion: The results emphasize that both original constituents and roast products contribute to the cellular antioxidant effectiveness of coffee.
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Compounds present in coffee roast products, notably 5-caffeoylquinic acid and caffeic acid, demonstrated direct antioxidant activity in HT-29 human colon cells.
“Work by Bakuradze et al.23 showed compounds present in coffee roast products - notably 5-caffeoylquinic acid, a type of chlorogenic acid, and caffeic acid - demonstrated direct antioxidant activity in HT-29 (human colon) cells23.”
From Acidity and Antioxidant Activity of Cold Brew Coffee (2018) · cites this paper as [23]
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BackgroundInfluentialDark coffee consumption protects human blood cells from spontaneous DNA damage
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“It is noteworthy that the activity of the roasted extracts diminishes over roasting time, an observation that is frequent in the bibliography (34,55,56).”
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“It contains complex mixtures of biochemically active components that have been hypothesized to impact the etiology of certain diseases ranging from carcinogenesis and cancer progression to cellular apoptosis, oxidative stress and inflammatory diseases.(6-8) These constituents, such as the palmitates, kahweol and cafes…”
Background
- Authors
- Bakuradze, T., Lang, R., Hofmann, T., Stiebitz, H., Bytof, G., Lantz, I., Baum, M., Eisenbrand, G., & Janzowski, C.
- Affiliations
- University of Kaiserslautern (DE)
- Technical University of Munich (DE)
- Corresponding author
- Janzowski, Christine
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2010-12
- Volume
- 54
- Issue
- 12
- Pages
- 1734-1743
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W2100170028
- Cited by
- 87
- References
- 44
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 5 · 2019: 8 · 2018: 8 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 8 · 2012: 7
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Nutrition & Food Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Keywords
- coffee, antioxidant activity, coffee roasting, caffeoylquinic acids, N-methylpyridinium, NAD(P)H:quinone oxidoreductase 1, gamma-glutamylcysteine synthetase, glutathione reductase, reactive oxygen species, DNA damage, HT-29 cells, Caco-2 cells, caffeic acid, trigonelline, catechol, Coffea arabica
- MeSH terms
- Antioxidants, Caffeic Acids, Cell-Free System, Coffee, Colon, DNA Damage, Glutamate-Cysteine Ligase, Glutathione Reductase, Humans, Plant Extracts, Pyridinium Compounds, Quinic Acid, NAD(P)H Dehydrogenase (Quinone), Reactive Oxygen Species, Caco-2 Cells, HT29 Cells, tert-Butylhydroperoxide
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