The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Resveratrol improves hepatic steatosis by inducing autophagy through the cAMP signaling pathway
Abstract
Scope: Resveratrol (RSV), a natural polyphenol, has been reported to attenuate nonalcoholic fatty liver disease (NAFLD); however, its underlying mechanism is unclear. Autophagy was recently identified as a critical protective mechanism during NAFLD development. Therefore, we investigated the role of autophagy in the beneficial effects of RSV on hepatic steatosis. Methods and results: Via Oil red O staining, triglyceride, and β‐hydroxybutyrate detection, we found that RSV decreased palmitate‐induced lipid accumulation and stimulated fatty acid β‐oxidation in hepatocytes. Based on Western blot assay, confocal microscopy and transmission electron microscopy, we found that RSV induced autophagy in hepatocytes, whereas autophagy inhibition markedly abolished RSV‐mediated hepatic steatosis improvement. Moreover, RSV increased cAMP levels and the levels of SIRT1 (sirtuin 1), pPRKA (phosphorylated protein kinase A), and pAMPK (phosphorylated AMP‐activated protein kinase), as well as SIRT1 activity in HepG2 cells. Incubation with inhibitors of AC (adenylyl cyclase), PRKA, AMPK, SIRT1, or with AC, PRKA, AMPK, or SIRT1 siRNA abolished RSV‐mediated autophagy. Similar results were obtained in mice with hepatic steatosis. Conclusion: RSV improved hepatic steatosis partially by inducing autophagy via the cAMP‐PRKA‐AMPK‐SIRT1 signaling pathway, which provides new evidence regarding RSV's effects on NAFLD treatment.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Moreover, RSV is a well-known activator of SIRT1 and our previous study also found that RSV improved hepatic steatosis partially by inducing autophagy via the SIRT1 signaling pathway in vitro and in vivo (36–38).”
In the citing paper
“Moreover, RSV is a well-known activator of SIRT1 and our previous study also found that RSV improved hepatic steatosis partially by inducing autophagy via the SIRT1 signaling pathway in vitro and in vivo (36–38).”
Citations
Cites
Ford, E. S., Giles, W. H., & Dietz, W. H. (2002) · JAMA · doi:10.1001/jama.287.3.356 · Cited by 6,698
Methods in Mammalian Autophagy Research
Mizushima, N., Yoshimori, T., & Levine, B. (2010) · Cell · doi:10.1016/j.cell.2010.01.028 · Cited by 4,497
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
Autophagy regulates lipid metabolism
Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796
Nonalcoholic Fatty Liver Disease: From Steatosis to Cirrhosis
Farrell, G. C., & Larter, C. Z. (2006) · Hepatology · doi:10.1002/hep.20973 · Cited by 2,428
Li, Y., Xu, S., Mihaylova, M. M., Zheng, B., Hou, X., Jiang, B., Park, O., Luo, Z., Lefai, É., Shyy, J. Y.-J., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.009 · Cited by 1,840
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
Lee, I. H., Cao, L., Mostoslavsky, R., Lombard, D. B., Liu, J., Bruns, N. E., Tsokos, M., Alt, F. W., & Finkel, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712145105 · Cited by 1,510
Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks
Alers, S., Löffler, A. S., Wesselborg, S., & Stork, B. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06159-11 · Cited by 1,483
Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases
Park, S. J., Ahmad, F., Philp, A., Baar, K., Williams, T., Luo, H., Ke, H., Rehmann, H., Taussig, R., Brown, A. L., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.017 · Cited by 1,370
Flagged first, then by citations
Research works printed but not linked: 5
- 10.1016/j.bbrc.2009.01.163 · DOI
- 10.1002/hep.26667 · DOI
- 10.1073/pnas.0712145105 · DOI
- 10.1038/nature01960 · DOI · Paper page
- Rojas C., 2013, Chronic treatment with low doses of resveratrol improves non‐alcoholic fatty liver disease by modulating endoplasmic reticulum stress related factors, Ann. Nutr. Metab., 62, 62
Cited by
Sorted by citations
Items 101–170 of 170
PAR2 promotes high-fat diet-induced hepatic steatosis by inhibiting AMPK-mediated autophagy
Kim, B. M., Kim, D. H., Park, Y. J., Ha, S., Choi, Y. J., Yu, H. S., Chung, K. W., & Chung, H. Y. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108769 · Cited by 16
Emerging Roles of Lipophagy in Cancer Metastasis
Yin, H., Shan, Y., Xia, T., Ji, Y., Yuan, L., You, Y., & You, B. (2022) · Cancers · doi:10.3390/cancers14184526 · Cited by 17
Jiang, Z., Wang, H., Yang, Y., Yao, Y., & Ma, H. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121259 · Cited by 15
Liu, T., Ma, L., Zheng, Z., Li, F., Liu, S., Xie, Y., & Li, G. (2017) · Oncotarget · doi:10.18632/oncotarget.19268 · Cited by 15
Awaad, A. K., Kamel, M. A. E.-N., Mohamed, M. M., Helmy, M. H., Youssef, M. I., Zaki, E. I., Essawy, M. M., & Hegazy, M. G. A. (2020) · Egyptian Liver Journal · doi:10.1186/s43066-020-00046-8 · Cited by 14
Wang, X., Wang, X., Cong, P., Wu, L., Ma, Y., Wang, Z., Jiang, T., & Xu, J. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109032 · Cited by 17
Shibayama, Y., Nagano, M., Hashiguchi, K., Fujii, A., & Iseki, K. (2019) · Functional Foods in Health and Disease · doi:10.31989/ffhd.v9i4.596 · Cited by 14
Korovila, I., Jung, T., Deubel, S., Grune, T., & Ott, C. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000816 · Cited by 13
Alcohol modulates autophagy and apoptosis in pig liver tissue
Potz, B. A., Lawandy, I. J., Clements, R., & Sellke, F. W. (2016) · Journal of Surgical Research · doi:10.1016/j.jss.2016.03.009 · Cited by 12
Thapa, K., Grewal, A. S., Kanojia, N., Rani, L., Sharma, N., & Singh, S. (2020) · Current Drug Discovery Technologies · doi:10.2174/1570163817666200121143959 · Cited by 12
Effects of polyphenols on non-alcoholic fatty liver disease: a case study of resveratrol
Zhao, Y., Ren, J., Chen, W., Gao, X., Yu, H., Li, X., Zheng, Y., & Yang, J. (2025) · Food & Function · doi:10.1039/d4fo04787g · Cited by 11
Yang, H., Chen, Q., Sun, F., Zhao, N., Wen, L., Li, L., & Ran, G. (2017) · PLoS ONE · doi:10.1371/journal.pone.0189156 · Cited by 11
Pan, M., Deng, Y., Zheng, C., Nie, H., Tang, K., Zhang, Y., & Yang, Q. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/8479680 · Cited by 11
Self-citationKe, W., Huang, J., Zhong, Y., Shi, Y., Yan, F., Huang, D., Wu, Y., Zheng, H., & Weng, Z. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.102907 · Cited by 11
Self-citationResveratrol Limits Lipogenesis and Enhance Mitochondrial Activity in HepG2 Cells
Izdebska, M., Herbet, M., Gawrońska‐Grzywacz, M., Piątkowska‐Chmiel, I., Korga-Plewko, A., Sysa, M., Iwan, M., Natorska‐Chomicka, D., Poleszak, E., Wróbel, A., et al. (2018) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/jpps29994 · Cited by 11
Lipophagy: A New Perspective of Natural Products in Type 2 Diabetes Mellitus Treatment
Huang, M., Yang, X., Wang, Z., Long, J., Wang, A., Zhang, Y., & Yan, D. (2021) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s310166 · Cited by 12
Self-citationMolecular Mechanism Underlying the Actions of Antioxidant Molecules in Digestive Disorders
Gagnière, J., & Bonnet, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805377-5.00014-x · Cited by 12
El-Deen, R. M., Heeba, G. H., Abdellatif, R., & Khalifa, M. M. (2019) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12530 · Cited by 11
Zhou, M., Hu, N., Liu, M., Deng, Y., He, L., Guo, C., Zhao, X., & Li, Y. (2020) · BioMed Research International · doi:10.1155/2020/5462063 · Cited by 10
Hormonal Regulation of Autophagy in Thyroid PCCL3 Cells and the Thyroids of Male Mice
Kurashige, T., Nakajima, Y., Shimamura, M. I., Yamada, M., & Nagayama, Y. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa054 · Cited by 10
The influence of dietary conditions in the effects of resveratrol on hepatic steatosis
Milton‐Laskibar, I., Aguirre, L., Gómez-Zorita, S., Rolo, A. P., & Portillo, M. P. (2020) · Food & Function · doi:10.1039/d0fo01943g · Cited by 10
Vasarri, M., Barletta, E., & Degl’Innocenti, D. (2021) · Pharmaceuticals · doi:10.3390/ph14100969 · Cited by 10
Li, Z., Li, J., Zhao, W., & Li, Y. (2020) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2020.04.011 · Cited by 10
Wan, Z., & Hallajzadeh, J. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70555 · Cited by 9
Xiao, Q., Wang, C., Yang, H. J., Gao, X., Chen, Z., Niu, Z., Hou, Y., Fu, C., Yan, Z., Zhu, G., et al. (2025) · Nano Letters · doi:10.1021/acs.nanolett.5c04561 · Cited by 9
Su, T., Wang, Z., Zhang, Z., Hou, Z., Han, X., Yang, F., & Liu, H. (2022) · Food & Nutrition Research · doi:10.29219/fnr.v66.8224 · Cited by 9
Han, W., Li, H., Jiang, H., Xu, H., Lin, Y., Chen, J., Bi, C., & Liu, Z. (2023) · PeerJ · doi:10.7717/peerj.15977 · Cited by 10
El‐Ashmawy, N. E., Khedr, E. G., Al‐Ashmawy, G. M., & Kamel, A. A. (2024) · Nutrition · doi:10.1016/j.nut.2024.112517 · Cited by 8
Ruan, X., Zhang, X.-M., Liu, L., & Zhang, J. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2231544 · Cited by 8
Klinger, S. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108467 · Cited by 8
Wang, Y., Wu, J., & Shi, A. (2022) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530322666220408123746 · Cited by 7
Natural Products Modulating Autophagy Pathway Against the Pathogenesis of Diabetes Mellitus
Li, L., Qi, J., & Li, H. (2018) · Current Drug Targets · doi:10.2174/1389450119666180726115805 · Cited by 8
Autophagy in Non-Alcoholic Fatty Liver Disease (NAFLD)
Kwanten, W. J., Martinet, W., & Francque, S. (2016) · InTech eBooks · doi:10.5772/64534 · Cited by 7
Taming fatty liver: can taurine combat metabolic dysfunction in MASLD?
Meng, L., Lu, F., Zhang, B., Ma, Y., & Gao, J. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02439-x · Cited by 6
Pharmacological agents for defatting livers by normothermic machine perfusion
Li, S., Chen, L., Li, M., & Lv, G. (2022) · Artificial Organs · doi:10.1111/aor.14478 · Cited by 7
Rodríguez, R. M., de Assis, L. V. M., Calvo, E., Colom‐Pellicer, M., Quesada‐Vázquez, S., Cruz‐Carrión, Á., Escoté, X., Oster, H., Aragonès, G., & Mulero, M. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202400554 · Cited by 7
Khan, S., & Ibrahim, M. (2022) · Natural Resources for Human Health · doi:10.53365/nrfhh/156261 · Cited by 6
Assessing Nutraceuticals for Hepatic Steatosis: A Standardized In Vitro Approach
Palasantzas, V. E. J. M., Struik, D., Bos, T., Withoff, S., Fu, J., Jonker, J. W., & Hoogerland, J. A. (2026) · Nutrients · doi:10.3390/nu18030388 · Cited by 5
Huo, D., Liang, W., Wang, D., Liu, Q., Wang, H., Wang, Y., Zhang, C., Cong, C., Su, X., Tan, X., et al. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109812 · Cited by 5
Resveratrol: Is It Really Good for Liver Health?
Weiskirchen, S., & Weiskirchen, R. (2017) · Hepatitis Monthly · doi:10.5812/hepatmon.12074 · Cited by 5
Kan, J.-X., Zhu, J.-P., Wei, T., & Chen, H. (2025) · Natural Product Communications · doi:10.1177/1934578x251394620 · Cited by 5
Self-citationAutophagy-Based Intervention Strategy in the Management of Hepatotoxicity
Zhao, C., Fu, Y., Ma, X., Zhao, S., Zhang, H., Yin, S., & Hu, H. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0051 · Cited by 4
Calcium-induced chloride secretion is decreased by Resveratrol in ileal porcine tissue
Hoppe, S., Breves, G., & Klinger, S. (2018) · BMC Research Notes · doi:10.1186/s13104-018-3825-4 · Cited by 4
Choi, H. G., Park, S. Y., Bae, S. H., Chang, S.-Y., & Kim, S. H. (2024) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2024.184 · Cited by 3
Guo, C.-H., Chen, W., Liao, C.-H., Huang, K., Chen, P.-Y., & Yang, C. (2018) · International Journal of Medical Sciences · doi:10.7150/ijms.26941 · Cited by 3
Zhang, M., Yuan, W., Li, C., Chen, C., Liu, X., Ma, Z., Xiang, Y., Chen, G., Wang, C., Li, L., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1574039 · Cited by 4
Mohamed, M. A.-E., Rihan, S., Elbakry, M. M. M., & Moselhy, S. S. (2024) · Natural Product Research · doi:10.1080/14786419.2024.2316328 · Cited by 2
Win, K. M., Latt, T. S., Bwa, A. H., Aye, K. M., Tun, K. S., & Gandhi, H. (2025) · Endocrine and Metabolic Science · doi:10.1016/j.endmts.2025.100218 · Cited by 2
Ameliorative Effect of Red Grape Leaf Extract on Insulin Resistance: In Vivo And In Silico Studies
Hamdy, N. M., & ElTantawy, H. M. (2024) · Journal of Angiotherapy · doi:10.25163/angiotherapy.859673 · Cited by 2
Li, C., Li, C., Wang, Y., You, S., Man, K. Y., Fan, Z., Qian, Y., Zhang, M., Cheng, K. K. Y., Mok, D. K., et al. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123158 · Cited by 1
Theodorou, R.-E., Vrettos, N., & Theodosis‐Nobelos, P. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48050465 · Cited by 1
Zhang, R., Wei, Y., Zhu, L., Huang, L., Yan, W., Chen, G., Dang, Y., & Feng, Z. (2018) · Europe PMC (PubMed Central) · Cited by 1
Leri, M., Bucciantini, M., & Stefani, M. (2019) · Florence Research (University of Florence)
A new mechanistic approach for cancer fighting of resveratrol
Ghorbani, A., & Zand, H. (2020) · Gene Reports · doi:10.1016/j.genrep.2020.100600
Tao, Z., Shi, L., & Cheng, Z. (2020) · Royal Society of Chemistry eBooks · doi:10.1039/9781839160608-00164 · Cited by 1
Optimization of Conditions for Cultivation of Babesia bigemina -infected RBCs
Rauf, U., Rashid, I., Akbar, H., Majeed, K. A., Raheem, I., Nawaz, J., & Durrani, A. Z. (2021) · Indian Journal of Animal Research · doi:10.18805/ijar.b-1276
Protective Effect of Resveratrol on Hepatocyte Apoptosis in Alcoholic Liver
Liu, Y., Liu, Y., Dou, B., & Madhujith, T. (2021) · Journal of Biobased Materials and Bioenergy · doi:10.1166/jbmb.2021.2069
陈, 雨. (2024) · Traditional Chinese Medicine · doi:10.12677/tcm.2024.138287
Treatment of Metabolic Diseases by Modulating Autophagy: Current Strategies and Future Directions
Yu, N., Tang, L., Mo, L., Peng, W., Shen, H., Mo, X., Lai, Q., & Tan, Y. (2025) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2025.138006
Zhou, X., Yu, L., Zhou, M., Hou, P., Yi, L., & Mi, M. (2021) · Figshare · doi:10.6084/m9.figshare.14812384
Self-citationZhou, X., Yu, L., Zhou, M., Hou, P., Yi, L., & Mi, M. (2021) · Figshare · doi:10.6084/m9.figshare.14812387
Self-citationYue, T., Huang, N., Zhao, Z., Yu, L., He, X., Yu, X., & Zheng, Y. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1744069
Design and evaluation of therapeutic particles modulating autophagy
Zagkou, S. (2021) · theses.fr (ABES) · doi:10.70675/945352cczdaf3z45fczb8dezdc79d3ca5100
Resveratrol Attenuates Obesity by Inducing GDF15 Expression via the p38‐ ATF3 Signaling Pathway
Mao, L., Hou, Y., 刘玮芳, Chen, J., Hu, W., Jiang, W., & Nie, T. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.72052
Fu, W., Wang, J., Lu, N., Guo, Z., Ong, S., Gao, Y., Zhou, H., Chang, X., & Meng, M. (2026) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl41721
Self-citationLahtinen, M., Salo, E., & Virtanen, J. (2024) · Specialty journal of Pharmacognosy Phytochemistry and Biotechnology · doi:10.51847/ssquzbasgf
Liu, M., Liu, Z., Leng, Y., Zhang, Q., Liu, C., Yao, Y., & Chen, X. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.154684
Self-citationBartoszewicz, M., & Niemczyk, M. (2026) · Aging · doi:10.18632/aging.206426
Ding, J., Wang, J., Lu, H., Zheng, X., Zha, Y., Sun, D., & Zhang, S. (2026) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2026.104283
Metadata
- Authors
- Zhang, Y., Chen, M., Zhou, Y., Yi, L., Gao, Y., Ran, L., Chen, S., Zhang, T., Zhou, X., Zou, D., Wu, B., Wu, Y., Chang, H., Zhu, J., Zhang, Q., & Mi, M.
- Affiliations
- Army Medical University (CN)
- Research Center for Nutrition and Food Safety Institute of Military Preventive Medicine Third Military Medical University Chongqing P. R. China
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2015-05-28
- Volume
- 59
- Issue
- 8
- Pages
- 1443-1457
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W1767926241
- Cited by
- 170
- References
- 56
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 14 · 2023: 13 · 2022: 12 · 2021: 19 · 2020: 22 · 2019: 16 · 2018: 22 · 2017: 16 · 2016: 16 · 2015: 3
- FWCI
- 9.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Nutrition & Food Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (30972469, 81273059)
- Technological Project of Chongqing (CSTC, 2011AB5040)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- resveratrol, hepatic steatosis, non-alcoholic fatty liver disease, autophagy, cAMP signaling, SIRT1, protein kinase A, AMPK, adenylate cyclase, fatty acid beta-oxidation, hepatocytes, polyphenols
- MeSH terms
- Resveratrol, Cyclic AMP, Adenylyl Cyclases, Animals, Antioxidants, Autophagy, Enzyme Induction, Enzyme Inhibitors, Fatty Acids, Nonesterified, Humans, Liver, Stilbenes, Second Messenger Systems, Dietary Supplements, RNA Interference, Microscopy, Electron, Transmission, Lipid Metabolism, Sirtuin 1, Hep G2 Cells, Mice, 129 Strain, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
