Resveratrol improves hepatic steatosis by inducing autophagy through the cAMP signaling pathway

Prevalence of the Metabolic Syndrome Among US Adults: Findings From the Third National Health and Nutrition Examination Survey

Ford, E. S., Giles, W. H., & Dietz, W. H. (2002) · JAMA · doi:10.1001/jama.287.3.356 · Cited by 6,698

Methods in Mammalian Autophagy Research

Mizushima, N., Yoshimori, T., & Levine, B. (2010) · Cell · doi:10.1016/j.cell.2010.01.028 · Cited by 4,497

Resveratrol improves health and survival of mice on a high-calorie diet

Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290

Autophagy regulates lipid metabolism

Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796

Nonalcoholic Fatty Liver Disease: From Steatosis to Cirrhosis

Farrell, G. C., & Larter, C. Z. (2006) · Hepatology · doi:10.1002/hep.20973 · Cited by 2,428

AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

Li, Y., Xu, S., Mihaylova, M. M., Zheng, B., Hou, X., Jiang, B., Park, O., Luo, Z., Lefai, É., Shyy, J. Y.-J., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.009 · Cited by 1,840

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

Lee, I. H., Cao, L., Mostoslavsky, R., Lombard, D. B., Liu, J., Bruns, N. E., Tsokos, M., Alt, F. W., & Finkel, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712145105 · Cited by 1,510

Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks

Alers, S., Löffler, A. S., Wesselborg, S., & Stork, B. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06159-11 · Cited by 1,483

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

Park, S. J., Ahmad, F., Philp, A., Baar, K., Williams, T., Luo, H., Ke, H., Rehmann, H., Taussig, R., Brown, A. L., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.017 · Cited by 1,370

The sirtuin family in health and disease

Wu, Q., Zhang, T., Chen, H., Yu, X., Lv, J.-L., Liu, Y., Liu, Y., Zheng, G., Zhao, J.-Q., Wei, Y., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01257-8 · Cited by 928

Resveratrol Attenuates Trimethylamine- N -Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota

Chen, M.-L., Yi, L., Zhang, Y., Zhou, X., Ran, L., Yang, J., Zhu, J.-D., Zhang, Q.-Y., & Mi, M.-T. (2016) · mBio · doi:10.1128/mbio.02210-15 · Cited by 754

Treatment of nonalcoholic fatty liver disease: role of AMPK

Smith, B. K., Marcinko, K., Desjardins, E. M., Lally, J., Ford, R. J., & Steinberg, G. R. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00225.2016 · Cited by 509

Neuroprotective Mechanisms of Resveratrol in Alzheimer’s Disease: Role of SIRT1

Gomes, B. A. Q., Silva, J. P. B., Romeiro, C. F. R., dos Santos, S. M., Rodrigues, C. A., Gonçalves, P. R., Sakai, J. T., Mendes, P. F. S., Varela, E. L. P., & Monteiro, M. C. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/8152373 · Cited by 403

Breaking fat: The regulation and mechanisms of lipophagy

Schulze, R. J., Sathyanarayan, A., & Mashek, D. G. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.06.008 · Cited by 243

Herbal drug discovery for the treatment of nonalcoholic fatty liver disease

Yan, T., Yan, N., Wang, P., Xia, Y., Hao, H., Wang, G., & Gonzalez, F. J. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.11.017 · Cited by 226

Resveratrol attenuates oxidative damage through activating mitophagy in an in vitro model of Alzheimer’s disease

Wang, H., Jiang, T., Li, W., Gao, N., & Zhang, T. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.10.021 · Cited by 214

Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway

Liu, H., Javaheri, A., Godar, R. J., Murphy, J., Ma, X., Rohatgi, N., Mahadevan, J., Hyrc, K. L., Säftig, P., Marshall, C. A., et al. (2017) · Autophagy · doi:10.1080/15548627.2017.1368596 · Cited by 194

Resveratrol alleviates MPTP‐induced motor impairments and pathological changes by autophagic degradation of α‐synuclein via SIRT1‐deacetylated LC3

Guo, Y., Dong, S., Xin-Xin, C., Feng, Y., Liu, T., Yin, M., Kuo, S., Tan, E., Zhao, W., & Wu, Y. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600111 · Cited by 190

Treatment for liver cancer: From sorafenib to natural products

Man, S., Luo, C., Yan, M., Zhao, G., Ma, L., & Gao, W. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113690 · Cited by 180

Resveratrol and caloric restriction prevent hepatic steatosis by regulating SIRT1-autophagy pathway and alleviating endoplasmic reticulum stress in high-fat diet-fed rats

Ding, S., Jiang, J., Zhang, G., Bu, Y., Zhang, G., & Zhao, X. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183541 · Cited by 175

Role of cAMP and phosphodiesterase signaling in liver health and disease

Wahlang, B., McClain, C., Barve, S., & Gobejishvili, L. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.06.005 · Cited by 168

Resveratrol prevents sarcopenic obesity by reversing mitochondrial dysfunction and oxidative stress via the PKA/LKB1/AMPK pathway

Huang, Y., Zhu, X., Chen, K., Lang, H., Zhang, Y., Hou, P., Ran, L., Zhou, M., Zheng, J., Yi, L., et al. (2019) · Aging · doi:10.18632/aging.101910 · Cited by 167

Resveratrol supplement inhibited the NF-κB inflammation pathway through activating AMPKα-SIRT1 pathway in mice with fatty liver

Tian, Y., Ma, J., Wang, W., Zhang, L., Xu, J., Wang, K., & Li, D. (2016) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2807-x · Cited by 164

A comprehensive overview of hepatoprotective natural compounds: mechanism of action and clinical perspectives

Domitrović, R., & Potočnjak, I. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1580-z · Cited by 158

Resveratrol-loaded PLGA nanoparticles: enhanced stability, solubility and bioactivity of resveratrol for non-alcoholic fatty liver disease therapy

Wan, S., Zhang, L., Quan, Y., & Wei, K. (2018) · Royal Society Open Science · doi:10.1098/rsos.181457 · Cited by 155

Procyanidin B2 ameliorates free fatty acids-induced hepatic steatosis through regulating TFEB-mediated lysosomal pathway and redox state

Su, H., Li, Y., Hu, D., Xie, L., Ke, H., Zheng, X., & Chen, W. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.08.024 · Cited by 151

Role of natural phenolics in hepatoprotection: A mechanistic review and analysis of regulatory network of associated genes

Saha, P., Talukdar, A. D., Nath, R., Sarker, S. D., Nahar, L., Sahu, J., & Choudhury, M. D. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00509 · Cited by 148

Emerging Liver–Kidney Interactions in Nonalcoholic Fatty Liver Disease

Musso, G., Cassader, M., Cohney, S. J., Pinach, S., Saba, F., & Gambino, R. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.08.005 · Cited by 134

Herbal Medicine in the Treatment of Non-Alcoholic Fatty Liver Diseases-Efficacy, Action Mechanism, and Clinical Application

Xu, Y., Guo, W., Zhang, C., Chen, F., Tan, H. Y., Li, S., Wang, N., & Feng, Y. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00601 · Cited by 140

Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity

Thellung, S., Corsaro, A., Nizzari, M., Barbieri, F., & Florio, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040901 · Cited by 118

Autophagy in Human Health and Disease: Novel Therapeutic Opportunities

Giampieri, F., Afrin, S., Forbes-Hernández, T. Y., Gasparrini, M., Cianciosi, D., Reboredo‐Rodríguez, P., Varela‐López, A., Quiles, J. L., & Battino, M. A. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7234 · Cited by 117

New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats

Ding, C., Zhao, Y., Shi, X., Zhang, N., Zu, G., Li, Z., Zhou, J., Gao, D., Lv, L., Tian, X., et al. (2016) · Scientific Reports · doi:10.1038/srep28734 · Cited by 115

The role of Resveratrol-induced mitophagy/autophagy in peritoneal mesothelial cells inflammatory injury via NLRP3 inflammasome activation triggered by mitochondrial ROS

Wu, J., Li, X., Zhu, G., Zhang, Y., He, M. Y., & Zhang, J. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.01.014 · Cited by 114

Autophagy in non-alcoholic fatty liver disease and alcoholic liver disease

Khambu, B., Yan, S., Huda, N., Liu, G., & Yin, X. (2018) · Liver Research · doi:10.1016/j.livres.2018.09.004 · Cited by 107

Resveratrol ameliorates hepatic steatosis and inflammation in methionine/choline-deficient diet-induced steatohepatitis through regulating autophagy

Ji, G., Wang, Y., Deng, Y., Li, X., & Jiang, Z. (2015) · Lipids in Health and Disease · doi:10.1186/s12944-015-0139-6 · Cited by 97

Resveratrol Attenuates Aβ25–35 Caused Neurotoxicity by Inducing Autophagy Through the TyrRS-PARP1-SIRT1 Signaling Pathway

Deng, H., & Mi, M. (2016) · Neurochemical Research · doi:10.1007/s11064-016-1950-9 · Cited by 96

Local intra-articular injection of resveratrol delays cartilage degeneration in C57BL/6 mice by inducing autophagy via AMPK/mTOR pathway

Qin, N., Wei, L., Li, W., Yang, W., Cai, L., Qian, Z., & Wu, S. (2017) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2017.06.002 · Cited by 93

Alternative treatment methods attenuate the development of NAFLD: A review of resveratrol molecular mechanisms and clinical trials

Charytoniuk, T., Drygalski, K., Konstantynowicz-Nowicka, K., Berk, K., & Chabowski, A. (2016) · Nutrition · doi:10.1016/j.nut.2016.09.001 · Cited by 92

Traditional Chinese herbal extracts inducing autophagy as a novel approach in therapy of nonalcoholic fatty liver disease

Liu, C., Liao, J., & Li, P. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i11.1964 · Cited by 75

Hepatoprotective and therapeutic effects of resveratrol: A focus on anti‐inflammatory and antioxidative activities

Chupradit, S., Bokov, D. O., Zamanian, M. Y., Heidari, M., & Hakimizadeh, E. (2021) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12746 · Cited by 81

Modulation of Autophagy for Controlling Immunity

Jang, Y. J., Kim, J. H., & Byun, S. (2019) · Cells · doi:10.3390/cells8020138 · Cited by 74

Natural products in non-alcoholic fatty liver disease (NAFLD): Novel lead discovery for drug development

Wang, L., Yan, Y., Wu, L., & Peng, J. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106925 · Cited by 79

Trigonelline prevents high cholesterol and high fat diet induced hepatic lipid accumulation and lipo-toxicity in C57BL/6J mice, via restoration of hepatic autophagy

Sharma, L., Lone, N. A., Knott, R. M., Hassan, A., & Abdullah, S. T. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.09.011 · Cited by 77

Research progress in use of traditional Chinese medicine monomer for treatment of non-alcoholic fatty liver disease

Zhou, H., Ma, C., Wang, C., Gong, L., Zhang, Y., & Li, Y. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173976 · Cited by 73

SIRT1: Harnessing multiple pathways to hinder NAFLD

Tian, C., Huang, R., & Xiang, M. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107155 · Cited by 78

8‐C‐(E‐phenylethenyl)quercetin from onion/beef soup induces autophagic cell death in colon cancer cells through ERK activation

Zhao, Y., Fan, D., Zheng, Z., Li, E. T. S., Chen, F., Cheng, K., & Wang, M. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600437 · Cited by 71

Irbesartan ameliorates hyperlipidemia and liver steatosis in type 2 diabetic db/db mice via stimulating PPAR-γ, AMPK/Akt/mTOR signaling and autophagy

Zhong, J., Gong, W., Lu, L., Chen, J., Lu, Z., Li, H., Liu, W., Liu, Y., Wang, M., Hu, R., et al. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.11.015 · Cited by 69

Resveratrol Ameliorates Lipid Droplet Accumulation in Liver Through a SIRT1/ ATF6-Dependent Mechanism

Zhou, R., Yi, L., Ye, X., Zeng, X., Liu, K., Qin, Y., Zhang, Q., & Mi, M. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000495898 · Cited by 67

Micheliolide alleviates hepatic steatosis in db/db mice by inhibiting inflammation and promoting autophagy via PPAR-γ-mediated NF-кB and AMPK/mTOR signaling

Zhong, J., Gong, W., Chen, J., Qing, Y., Shu-yue, W., Li, H., Huang, C., Chen, Y., Wang, Y., Xu, Z.-Z., et al. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.03.036 · Cited by 66

Resveratrol ameliorates diet-induced dysregulation of lipid metabolism in zebrafish (Danio rerio)

Ran, G., Li, Y., Lin, L., Yan, Q., Yi, W., Ying, C., Wu, H., & Ye, X. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180865 · Cited by 64

Hypericin attenuates nonalcoholic fatty liver disease and abnormal lipid metabolism via the PKA-mediated AMPK signaling pathway in vitro and in vivo

Chen, L., Li, Y., Bai, M., Huang, Y., Yang, H., Liu, L., Wang, S., Yu, C., Song, Z., Bao, Y., et al. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104657 · Cited by 60

Physicochemical properties and antioxidant potential of phosvitin–resveratrol complexes in emulsion system

Duan, X. L., Li, M., Ma, H., Xu, X., Jin, Z., & Liu, X. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.03.055 · Cited by 56

Herbal Extracts and Natural Products in Alleviating Non-alcoholic Fatty Liver Disease via Activating Autophagy

Zhang, L. R., Yao, Z., & Ji, G. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01459 · Cited by 56

Dietary Polyphenols in Metabolic and Neurodegenerative Diseases: Molecular Targets in Autophagy and Biological Effects

García-Aguilar, A., Palomino, O. M., Benito, M., & Guillén, C. (2021) · Antioxidants · doi:10.3390/antiox10020142 · Cited by 54

Potential therapeutic effects of polyphenols in Parkinson’s disease: in vivo and in vitro pre-clinical studies

Giuliano, C., Cerri, S., & Blandini, F. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.290879 · Cited by 52

Fabrication and Characterization of a Microemulsion Stabilized by Integrated Phosvitin and Gallic Acid

Jiang, B., Wang, X., Wang, L., Wu, S., Li, D., Liu, C., & Feng, Z. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c00945 · Cited by 50

Dysregulated Autophagy Mediates Sarcopenic Obesity and Its Complications via AMPK and PGC1α Signaling Pathways: Potential Involvement of Gut Dysbiosis as a Pathological Link

Ryu, J. Y., Choi, H. M., Yang, H.-I., & Kim, K. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186887 · Cited by 52

Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol‐induced steatosis

Avila, D. V., Barker, D. F., Zhang, J., McClain, C. J., Barve, S. S., & Gobejishvili, L. (2016) · The Journal of Pathology · doi:10.1002/path.4760 · Cited by 49

Current innovations in nutraceuticals and functional foods for intervention of non-alcoholic fatty liver disease

Zhao, M., Chen, S., Ji, X., Shen, X., You, J., Liang, X., Yin, H., & Zhao, L. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105517 · Cited by 50

Roflupram, a Phosphodiesterase 4 Inhibitior, Suppresses Inflammasome Activation through Autophagy in Microglial Cells

You, T., Cheng, Y., Zhong, J., Bi, B., Zeng, B., Zheng, W., Wang, H., & Xu, J. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00065 · Cited by 47

Dihydromyricetin ameliorates liver fibrosis via inhibition of hepatic stellate cells by inducing autophagy and natural killer cell-mediated killing effect

Zhou, X., Yu, L., Zhou, M., Hou, P., Yi, L., & Mi, M. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-021-00589-6 · Cited by 47

Emerging Roles of Impaired Autophagy in Fatty Liver Disease and Hepatocellular Carcinoma

Niture, S. K., Lin, M., Ríos-Colón, L., Qi, Q., Moore, J. T., & Kumar, D. (2021) · International Journal of Hepatology · doi:10.1155/2021/6675762 · Cited by 44

Resveratrol Induces Expression of Metabolic and Antioxidant Machinery and Protects Tilapia under Cold Stress

Wang, M., Wang, Y.-C., Peng, H.-W., Hseu, J.-R., Wu, G.-C., Chang, C., & Tseng, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093338 · Cited by 41

Involvement of 5′AMP-Activated Protein Kinase (AMPK) in the Effects of Resveratrol on Liver Steatosis

Trepiana, J., Milton‐Laskibar, I., Gómez‐Zorita, S., Eseberri, I., González, M. A., Fernández‐Quintela, A., & Portillo, M. P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113473 · Cited by 44

Tangshen Formula Alleviates Hepatic Steatosis by Inducing Autophagy Through the AMPK/SIRT1 Pathway

Wang, Y., Zhao, H., Li, X., Li, N., Wang, Q., Liu, Y., Liang, Q., Shao, Z., Zhang, N., Zhao, T., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00494 · Cited by 41

Autophagy in Hepatic Steatosis: A Structured Review

Ramos, V. D. M., Kowaltowski, A. J., & Kakimoto, P. A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.657389 · Cited by 42

Cellular cholesterol accumulation modulates high fat high sucrose (HFHS) diet-induced ER stress and hepatic inflammasome activation in the development of non-alcoholic steatohepatitis

Bashiri, A., Nesan, D., Tavallaee, G., Sue-Chue-Lam, I., Chien, K., Maguire, G. F., Naples, M., Zhang, J., Magomedova, L., Adeli, K., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.04.005 · Cited by 41

Red raspberries suppress NLRP3 inflammasome and attenuate metabolic abnormalities in diet-induced obese mice

Zhu, M. J., Kang, Y., Xue, Y., Liang, X., García, M. P. G., Rodgers, D. B., Kagel, D. R., & Du, ‬. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.10.012 · Cited by 38

Resveratrol, an activator of SIRT1, improves ER stress by increasing clusterin expression in HepG2 cells

Lee, J., Hong, S., Kwon, H., Park, S. E., Rhee, E., Park, C., Oh, K.-W., Park, S., & Lee, W. (2019) · Cell Stress and Chaperones · doi:10.1007/s12192-019-01012-z · Cited by 39

Plant phenols and autophagy

Зенков, Н. К., Владимирович, Ч. А., Kozhin, P. M., Кандалинцева, Н. В., Мартинович, Г. Г., & Брониславовна, М. Е. (2016) · Biochemistry (Moscow) · doi:10.1134/s0006297916040015 · Cited by 38

The beneficial effects of resveratrol on steatosis and mitochondrial oxidative stress in HepG2 cells

Izdebska, M., Piątkowska‐Chmiel, I., Korolczuk, A., Herbet, M., Gawrońska‐Grzywacz, M., Gieroba, R., Sysa, M., Czajkowska-Bania, K., Cygal, M., Korga-Plewko, A., et al. (2017) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2016-0561 · Cited by 38

Does Resveratrol Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)?

Kasprzak‐Drozd, K., Niziński, P., Kasprzak, P., Kondracka, A., Oniszczuk, T., Rusinek, A., & Oniszczuk, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073746 · Cited by 39

Resveratrol Potently Counteracts Quercetin Starvation‐Induced Autophagy and Sensitizes HepG2 Cancer Cells to Apoptosis

Tomas‐Hernández, S., Blanco, J., Rojas, C., Roca‐Martínez, J., Ojeda, M. J., Beltrán‐Debón, R., García-Vallvé, S., Pujadas, G., Arola, L., & Mulero, M. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700610 · Cited by 36

Analysis of proautophagic activities of Citrus flavonoids in liver cells reveals the superiority of a natural polyphenol mixture over pure flavones

Lascala, A., Martino, C., Parafati, M., Salerno, R., Oliverio, M., Pellegrino, D., Mollace, V., & Janda, E. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.04.005 · Cited by 37

Coniferaldehyde ameliorates the lipid and glucose metabolism in palmitic acid‐induced HepG2 cells via the LKB1/AMPK signaling pathway

Gai, H., Zhou, F. J., Zhang, Y., Ai, J., Zhan, J., You, Y., & Huang, W. (2020) · Journal of Food Science · doi:10.1111/1750-3841.15482 · Cited by 39

Visualization and bibliometric analysis of cAMP signaling system research trends and hotspots in cancer

Tang, C., Liu, D., Fan, Y., Yu, J. G., Li, C., Su, J., & Wang, C. (2020) · Journal of Cancer · doi:10.7150/jca.47158 · Cited by 35

Hepatic autophagy and mitophagy status in dairy cows with subclinical and clinical ketosis

Shen, T., Xu, F., Fang, Z., Loor, J. J., Ouyang, H., Chen, M., Jin, B., Wang, X., Shi, Z., Zhu, Y., et al. (2021) · Journal of Dairy Science · doi:10.3168/jds.2020-19150 · Cited by 34

Progressing neurobiological strategies against proteostasis failure: Challenges in neurodegeneration

Amanullah, A., Upadhyay, A., Joshi, V., Mishra, R., Jana, N. R., & Mishra, A. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.08.005 · Cited by 34

Application of herbs and active ingredients ameliorate non-alcoholic fatty liver disease under the guidance of traditional Chinese medicine

Zhou, Z., Zhang, J., You, L., Wang, T., Wang, K., Wang, L., Kong, X., Gao, Y., & Sun, X. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1000727 · Cited by 32

Investigation on the Use of Traditional Chinese Medicine for Polycystic Ovary Syndrome in a Nationwide Prescription Database in Taiwan

Liao, W., Chiang, J., Li, C., Lee, M.-T., Su, C.-C., & Yen, H. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7070179 · Cited by 32

Resveratrol Alleviates Endoplasmic Reticulum Stress–Associated Hepatic Steatosis and Injury in Mice Challenged with Tunicamycin

Chen, Y., Zhang, H., Chen, Y., Zhang, Y., Shen, M., Jia, P., Ji, S., & Wang, T. Z. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000105 · Cited by 31

Plants-based medicine implication in the evolution of chronic liver diseases

Foghis, M., BUNGAU, S. G., Bungău, A. F., Vesa, C. M., Purza, A. L., Tarce, A. G., Ţiţ, D. M., Pallag, A., Behl, T., Hassan, S. S. U., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114207 · Cited by 31

Regulation of autophagy by plant‐based polyphenols: A critical review of current advances in glucolipid metabolic diseases and food industry applications

Wang, Z., Quan, W., Zeng, M., Wang, Z., Chen, Q., Chen, J., Christian, M., & He, Z. (2023) · Food Frontiers · doi:10.1002/fft2.255 · Cited by 33

Chlorogenic Acid Modulates Autophagy by Inhibiting the Activity of ALKBH5 Demethylase, Thereby Ameliorating Hepatic Steatosis

Meng, F., Song, C., Liu, J., Chen, F., Zhu, Y., Fang, X., Cao, Q., Ma, D., Wang, Y., & Zhang, C. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c03710 · Cited by 32

Biological Role and Related Natural Products of SIRT1 in Nonalcoholic Fatty Liver

Meng, D., Zhang, F., Yu, W., Zhang, X., Yin, G., Liang, P., Feng, Y., Chen, S., & Liu, H. (2023) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s437865 · Cited by 32

A comprehensive review of phytoconstituents in liver cancer prevention and treatment: targeting insights into molecular signaling pathways

Islam, M. R., Rauf, A., Alash, S., Fakir, M. N. H., Thufa, G. K., Sowa, M. S., Mukherjee, D., Kumar, H. M., Hussain, M. S., Aljohani, A. S. M., et al. (2024) · Medical Oncology · doi:10.1007/s12032-024-02333-5 · Cited by 30

Potential use of C-phycocyanin in non-alcoholic fatty liver disease

Ma, P., Huang, R., Jiang, J., Ding, Y., Li, T., & Ou, Y. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.04.001 · Cited by 30

Tactics with Prebiotics for the Treatment of Metabolic Dysfunction-Associated Fatty Liver Disease via the Improvement of Mitophagy

Tsuji, A., Yoshikawa, S., Ikeda, Y., Taniguchi, K., Sawamura, H., Morikawa, S., Nakashima, M., Asai, T. T., & Matsuda, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065465 · Cited by 33

Novel GLP-1 Analog Supaglutide Stimulates Insulin Secretion in Mouse and Human Islet Beta-Cells and Improves Glucose Homeostasis in Diabetic Mice

Ren, L., Cui, Q., Liu, W., Wang, L., Liao, Y., Feng, Y., Sun, W., Yang, Y., Zhang, Z., Jin, T., et al. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00930 · Cited by 29

Targeting AMPK related signaling pathways: A feasible approach for natural herbal medicines to intervene non-alcoholic fatty liver disease

Cai, Y., Fang, L., Chen, F., Zhong, P., Zheng, X., Xing, H., Fan, R., Yuan, L., Peng, W., & Li, X. (2024) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2024.101052 · Cited by 31

Hepatic PKA inhibition accelerates the lipid accumulation in liver

Yang, J., Zhang, X., Yi, L., Yang, L., Wang, W. E., Zeng, C., Mi, M., & Chen, X. (2019) · Nutrition & Metabolism · doi:10.1186/s12986-019-0400-5 · Cited by 27

Autophagy is involved in acetylshikonin ameliorating non-alcoholic steatohepatitis through AMPK/mTOR pathway

Zeng, J., Zhu, B., & Su, M. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.07.094 · Cited by 26

Resveratrol Metabolites Are Able to Reduce Steatosis in Cultured Hepatocytes

Trepiana, J., Krisa, S., Renouf, E., & Portillo, M. P. (2020) · Pharmaceuticals · doi:10.3390/ph13100285 · Cited by 27

Resveratrol Modulates the Redox Response and Bile Acid Metabolism to Maintain the Cholesterol Homeostasis in Fish Megalobrama amblycephala Offered a High-Carbohydrate Diet

Ge, Y., Zhang, L., Chen, W., Sun, M., Liu, W., & Li, X. (2023) · Antioxidants · doi:10.3390/antiox12010121 · Cited by 26

Crosstalk between kidney and liver in non-alcoholic fatty liver disease: mechanisms and therapeutic approaches

Sharma, N., Sircar, A., Anders, H., & Gaikwad, A. B. (2020) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2020.1745851 · Cited by 25

Human diet‐derived polyphenolic compounds and hepatic diseases: From therapeutic mechanisms to clinical utilization

Hu, Q., Zhang, W., Wei, F., Huang, M., Shu, M., Song, D., Wen, J., Wang, J.-D., Nian, Q., Ma, X., et al. (2023) · Phytotherapy Research · doi:10.1002/ptr.8043 · Cited by 23

Inhibited autophagy impairs systemic nutrient metabolism in Nile tilapia

Han, S., Wang, J., Zhang, Y., Qiao, F., Chen, L., Zhang, M., & Du, Z. (2019) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2019.06.021 · Cited by 23

Abnormal expression of liver autophagy and apoptosis-related mRNA in fatty liver haemorrhagic syndrome and improvement function of resveratrol in laying hens

Wang, X., Xing, C., Yang, F., Zhou, S., Li, G., Zhang, C., Cao, H., & Hu, G. (2019) · Avian Pathology · doi:10.1080/03079457.2019.1698712 · Cited by 23

Lipophagy: Molecular Mechanisms and Implications in Hepatic Lipid Metabolism

Feng, S., Sun, Z., Xiao, J., Li, L., Wu, Y., Wu, C., Lin, L., Liu, J., & Zeng, B. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2801006 · Cited by 22

Modulation of Autophagy: A Novel “Rejuvenation” Strategy for the Aging Liver

Xu, F., Tautenhahn, H., Dirsch, O., & Dahmen, U. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6611126 · Cited by 21

Resveratrol modifies biliary secretion of cholephilic compounds in sham-operated and cholestatic rats

Doleželová, E., Prašnická, A., Cermanová, J., Carazo, A., Hyršová, L., Hroch, M., Mokrý, J., Adamcová, M., Mrkvicová, A., Pávek, P., et al. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i43.7678 · Cited by 22

Resveratrol Inhibits Porcine Intestinal Glucose and Alanine Transport: Potential Roles of Na+/K+-ATPase Activity, Protein Kinase A, AMP-Activated Protein Kinase and the Association of Selected Nutrient Transport Proteins with Detergent Resistant Membranes

Klinger, S., & Breves, G. (2018) · Nutrients · doi:10.3390/nu10030302 · Cited by 21

A Decade of Mighty Lipophagy: What We Know and What Facts We Need to Know?

Khawar, M. B., Abbasi, M. H., Rafiq, M., Naz, N., Mehmood, R., & Sheikh, N. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5539161 · Cited by 18

A novel combination of metformin and resveratrol alleviates hepatic steatosis by activating autophagy through the cAMP/AMPK/SIRT1 signaling pathway

Afshari, H., Noori, S., & Zarghi, A. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02520-7 · Cited by 20

Role of MST1 in the regulation of autophagy and mitophagy: implications for aging-related diseases

Shang, H., VanDusseldorp, T. A., Ma, R.-G., Zhao, Y., Cholewa, J. M., Zanchi, N. E., & Xia, Z. (2022) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-022-00904-6 · Cited by 17

A soy glycinin derived octapeptide protects against MCD diet induced non-alcoholic fatty liver disease in mice

Ma, P., Huang, R., & Ou, Y. (2022) · Food Science and Human Wellness · doi:10.1016/j.fshw.2022.06.012 · Cited by 16

Pharmacology of bioactive compounds from plant extracts for improving non-alcoholic fatty liver disease through endoplasmic reticulum stress modulation: A comprehensive review

Huang, L., Tan, L., Lv, Z., Chen, W., & Wu, J. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e25053 · Cited by 18

Unlocking the Therapeutic Potential of Autophagy Modulation by Natural Products in Tackling Non‐Alcoholic Fatty Liver Disease

Niazpour, F., & Meshkani, R. (2025) · Phytotherapy Research · doi:10.1002/ptr.8463 · Cited by 16

Mechanisms of kidney dysfunction in the cirrhotic patient: Non-hepatorenal acute-on-chronic kidney damage considerations

Muciño-Bermejo, M.-J. (2019) · Annals of Hepatology · doi:10.1016/j.aohep.2019.06.022 · Cited by 16

A novel combination of metformin and resveratrol alleviates hepatic steatosis by activating autophagy through the cAMP/AMPK/SIRT1 signaling pathway

Afshari, H., Noori, S., & Zarghi, A. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02520-7 · Cited by 20

Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase

SHANG, J., CHEN, L.-L., XIAO, F.-X., SUN, H., DING, H.-C., & XIAO, H. (2008) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2008.00807.x · Cited by 274

Resveratrol protects against nonalcoholic fatty liver disease by improving lipid metabolism and redox homeostasis via the PPARα pathway

Huang, Y., Lang, H., Chen, K., Zhang, Y., Gao, Y., Ran, L., Yi, L., Mi, M., & Zhang, Q. (2019) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2019-0057 · Cited by 79

Resveratrol ameliorates hepatic steatosis and inflammation in methionine/choline-deficient diet-induced steatohepatitis through regulating autophagy

Ji, G., Wang, Y., Deng, Y., Li, X., & Jiang, Z. (2015) · Lipids in Health and Disease · doi:10.1186/s12944-015-0139-6 · Cited by 97

Effects of resveratrol in experimental and clinical non-alcoholic fatty liver disease

Heebøll, S. (2014) · World Journal of Hepatology · doi:10.4254/wjh.v6.i4.188 · Cited by 60