Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase
Abstract
Aim To investigate whether resveratrol (RSV) can improve non-alcoholic fatty liver disease (NAFLD) and to find the possible mechanism.Methods Rats fed a high-fat diet were treated with RSV. The liver histology was observed. Hyperinsulinemic euglycemic clamp was performed to assess insulin sensitivity. Fat accumulation was induced in HepG2 cells, and the cells were treated with RSV. AMP-activated protein kinase (AMPK) phosphorylation levels were determined both in the animal study and cell study.Results Rats fed a high-fat diet developed abdominal obesity, NAFLD, and insulin resistance (IR), which were markedly improved by 10 weeks of RSV administration. RSV treatment prevented triacylglycerol (TG) accumulation in HepG2 cells that were incubated with high concentration of glucose and insulin. Both in vivo and in vitro studies showed that RSV treatment could promote the phosphorylation of AMPK, which in this study, suppressed 2 lipogenesis gene expressions, contributing to the improvement of NAFLD and IR.Conclusion The results indicated that by reducing TG accumulation and improving IR, RSV could protect the liver from NAFLD. The activation of AMPK was involved in the mechanism. RSV has the therapeutic potential for preventing or treating NAFLD and IR-related metabolic disorders.
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Animal studies demonstrated that resveratrol could stimulate energy expenditure and protect against a high-fat diet-induced weight gain via induction of FAO and reduced lipogenesis, mediated by activation of the AMPK-SIRT1 axis.
“Animal studies have also demonstrated that resveratrol could stimulate energy expenditure and protect against a high-fat diet-induced weight gain (250), via induction of FAO and reduced lipogenesis, mediated by activation of the AMPK-SIRT1 axis (251, 252).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [252]
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- Authors
- SHANG, J., CHEN, L.-L., XIAO, F.-X., SUN, H., DING, H.-C., & XIAO, H.
- Affiliations
- Wuhan Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
- ORCID
- Venue
- Acta Pharmacologica Sinica
- Published
- 2008-06
- Volume
- 29
- Issue
- 6
- Pages
- 698-706
- ISSN
- 0253-9756 (ISSN-L)
- 1671-4083
- 1745-7254
- OpenAlex
- W2028319504
- Cited by
- 274
- References
- 37
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 5 · 2023: 17 · 2022: 13 · 2021: 17 · 2020: 17 · 2019: 16 · 2018: 15 · 2017: 15 · 2016: 14 · 2015: 23 · 2014: 22 · 2013: 27 · 2012: 18
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Pharmacologica Sinica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- resveratrol, non-alcoholic fatty liver disease, AMPK, insulin resistance, high-fat diet, lipogenesis, hepatic steatosis, abdominal obesity, AMPK phosphorylation
- MeSH terms
- Resveratrol, Animals, Antioxidants, Diet, Enzyme Activation, Fatty Liver, Humans, Hyperinsulinism, Liver, Male, Stilbenes, Triglycerides, Glucose Clamp Technique, Cyclic AMP-Dependent Protein Kinases, Rats
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