Cited by 77Atherosclerosis and Cardiovascular DiseasesFlavonoids in Medical ResearchPhytochemicals and Antioxidant Activities

Quercetin protects against atherosclerosis by inhibiting dendritic cell activation

Lin, Weiqun, Wang, Wenting, Wang, Dongliang, Ling, Wenhua·2017·Molecular Nutrition & Food Research

Abstract

Scope Quercetin is a typical flavonol with atheroprotective effects, but the effect of quercetin on dendritic cell (DC) maturation in relation to atherosclerosis has not yet been clearly defined. Thus, we investigated whether quercetin can inhibit DC maturation and evaluated its potential value in atherosclerosis progression in ApoE−/− mice. Methods and results Quercetin consumption inhibited DC activation, inflammatory response and suppressed the progression of atherosclerosis in ApoE−/− mice. Subsequently, quercetin treatment inhibited the phenotypic and functional maturation of DCs, as evidenced not only by downregulation of CD80, CD86, MHC-II, IL-6 and IL-12 but also by a reduction in the ability to stimulate T cell allogeneic proliferation. Finally, an in vitro study demonstrated that quercetin inhibited DC maturation via upregulation of Dabs, which then downregulated the Src/PI3K/Akt-NF-κB-inflammatory pathways. Conclusions Our data indicate that quercetin attenuates atherosclerosis progression by regulating DC activation via Dab2 protein expression.

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Crossref · 10.1002/mnfr.201700031

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  • Quercetin-mediated up-regulation of Dab2 expression attenuates atherosclerosis.

    “Interestingly, another report showed that quercetin-mediated up-regulation of Dab2 expression attenuates the atherosclerosis [137].”

    From Insights of Endocytosis Signaling in Health and Disease (2023) · cites this paper as [137]

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Authors
Lin, W., Wang, W., Wang, D., & Ling, W.
Affiliations
Sun Yat-sen University (CN)
Corresponding author
  • Wang, Dongliang
  • Ling, Wenhua
Venue
Molecular Nutrition & Food Research
Publisher
Wiley
Published
2017-06-16
Volume
61
Issue
9
Pages
1700031
ISSN
1613-4125 (ISSN-L)
OpenAlex
W2609561198
Cited by
77
References
46
Citations by year
2026: 6 · 2025: 7 · 2024: 8 · 2023: 13 · 2022: 8 · 2021: 10 · 2020: 11 · 2019: 6 · 2018: 5 · 2017: 3
FWCI
3.09
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Nutrition & Food Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81370369, 81573141)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
quercetin, atherosclerosis, dendritic cell maturation, flavonols, ApoE-deficient mice, Dab2, NF-κB signaling, inflammation, T cell proliferation, CD80, CD86, MHC class II, interleukin-6, IL-12
MeSH terms
Animals, Apolipoproteins E, Cells, Cultured, Dendritic Cells, Male, Mice, Inbred C57BL, Quercetin, NF-kappa B, Protein Transport, Adaptor Proteins, Vesicular Transport, Adaptor Proteins, Signal Transducing, Atherosclerosis, Apoptosis Regulatory Proteins, Mice

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