Quercetin protects against atherosclerosis by inhibiting dendritic cell activation
Abstract
Scope Quercetin is a typical flavonol with atheroprotective effects, but the effect of quercetin on dendritic cell (DC) maturation in relation to atherosclerosis has not yet been clearly defined. Thus, we investigated whether quercetin can inhibit DC maturation and evaluated its potential value in atherosclerosis progression in ApoE−/− mice. Methods and results Quercetin consumption inhibited DC activation, inflammatory response and suppressed the progression of atherosclerosis in ApoE−/− mice. Subsequently, quercetin treatment inhibited the phenotypic and functional maturation of DCs, as evidenced not only by downregulation of CD80, CD86, MHC-II, IL-6 and IL-12 but also by a reduction in the ability to stimulate T cell allogeneic proliferation. Finally, an in vitro study demonstrated that quercetin inhibited DC maturation via upregulation of Dabs, which then downregulated the Src/PI3K/Akt-NF-κB-inflammatory pathways. Conclusions Our data indicate that quercetin attenuates atherosclerosis progression by regulating DC activation via Dab2 protein expression.
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Quercetin-mediated up-regulation of Dab2 expression attenuates atherosclerosis.
“Interestingly, another report showed that quercetin-mediated up-regulation of Dab2 expression attenuates the atherosclerosis [137].”
From Insights of Endocytosis Signaling in Health and Disease (2023) · cites this paper as [137]
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- Authors
- Lin, W., Wang, W., Wang, D., & Ling, W.
- Affiliations
- Sun Yat-sen University (CN)
- Corresponding author
- Wang, Dongliang
- Ling, Wenhua
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2017-06-16
- Volume
- 61
- Issue
- 9
- Pages
- 1700031
- ISSN
- 1613-4125 (ISSN-L)
- OpenAlex
- W2609561198
- Cited by
- 77
- References
- 46
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 8 · 2023: 13 · 2022: 8 · 2021: 10 · 2020: 11 · 2019: 6 · 2018: 5 · 2017: 3
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Molecular Nutrition & Food Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81370369, 81573141)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- quercetin, atherosclerosis, dendritic cell maturation, flavonols, ApoE-deficient mice, Dab2, NF-κB signaling, inflammation, T cell proliferation, CD80, CD86, MHC class II, interleukin-6, IL-12
- MeSH terms
- Animals, Apolipoproteins E, Cells, Cultured, Dendritic Cells, Male, Mice, Inbred C57BL, Quercetin, NF-kappa B, Protein Transport, Adaptor Proteins, Vesicular Transport, Adaptor Proteins, Signal Transducing, Atherosclerosis, Apoptosis Regulatory Proteins, Mice
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