[Retracted] Quercetin Prevents Radiation‐Induced Oral Mucositis by Upregulating BMI‐1
Open accessAbstract
Radiation‐induced oral mucositis is a major adverse event of radiotherapy. Severe oral mucositis may cause unwanted interruption in radiotherapy and reduce long‐term survival in cancer patients receiving radiotherapy, but until now, there have been no effective options for preventing radiation‐induced oral mucositis. Quercetin is a flavonoid that is widely found in food species and has anti‐inflammatory, antioxidant, and anticancer activities. In this study, we investigated a new role of quercetin in preventing radiation‐induced oral mucositis. Quercetin exerted preventive effects against radiation‐induced oral mucositis induced by single‐dose (25 Gy) ionizing radiation or fractionated ionizing radiation (8 Gy × 3) in C57BL/6 mice and maintained the proliferation ability of basal epithelial cells. Quercetin pretreatment alleviated reactive oxygen species generation, NF‐κ B pathway activation, and downstream proinflammatory cytokine production and reduced DNA double‐strand breaks and cellular senescence induced by ionizing radiation. Quercetin also upregulated BMI‐1 expression in oral epithelial cells and promoted ulcer repair. In addition, quercetin exerted similar radioprotective effects in irradiated primary cultured normal human keratinocytes, reduced reactive oxygen species generation and proinflammatory cytokine release, and promoted DNA double‐strand break repair and wound healing by upregulating the expression of BMI‐1, which is a polycomb group protein. Thus, quercetin can block multiple pathological processes of radiation‐induced oral mucositis by targeting BMI‐1 and may be a potential treatment option for preventing radiation‐induced oral mucositis.
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Treatment with quercetin significantly lowers levels of ROS and inflammatory cytokines, reduces expression of SA-β gal, p16 and p53, and markedly increases that of antioxidant enzymes SOD and CAT, regardless of the type of oxidative trigger used to induce senescence.
“Results obtained on different cell lines show that treatment with quercetin significantly lowers the levels of ROS and inflammatory cytokines, reduces the expression of SA-β gal, p16 and p53 and markedly increases that of the antioxidant enzymes SOD and CAT, regardless of the type of oxidative trigger used to induce senescence [258,259,260,261,262].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [258]
Quercetin is a flavonol known for its antioxidant, anti-inflammatory, antitumor, and senolytic properties.
“Quercetin is a flavonol known for its antioxidant, anti-inflammatory, antitumor, and senolytic properties [258].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [258]
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The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
- Authors
- Zhang, J., Hong, Y., Liuyang, Z., Li, H., Jiang, Z., Tao, J., Liu, H., Xie, A., Feng, Y., Dong, X., Wang, Y., Dong, Q., & Wang, G.
- Affiliations
- Sir Run Run Shaw Hospital (CN)
- Huazhong Agricultural University (CN)
- Corresponding author
- Dong, Qinghua
- Wang, Guanyu
- ORCID
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2021-01
- Volume
- 2021
- Issue
- 1
- Pages
- 2231680-2231680
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC8643266
- OpenAlex
- W3215961858
- Cited by
- 28
- References
- 40
- Citations by year
- 2025: 1 · 2024: 12 · 2023: 6 · 2022: 5 · 2021: 4
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- retraction (2024-01-09)
- Open access
- hybrid
- doi.org
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Basic Public Welfare Research Program of Zhejiang Province (LGD19H160005)
- Science and Technology Department of Zhejiang Province (LGF20H220001)
- Natural Science Foundation of Zhejiang Province (LY17H220001)
- Health Commission of Zhejiang Province (2019ZD029, 2019ZD010)
- National Natural Science Foundation of China (81472213, 81272493)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Oral health in cancer treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Health Sciences › Dentistry › Periodontics › Oral Health Pathology and Treatment
- Keywords
- quercetin, radiation-induced oral mucositis, BMI1, Polycomb group proteins, radiation protection, ionizing radiation, reactive oxygen species, NF-κB signaling, inflammatory cytokines, DNA double-strand break repair, cellular senescence, keratinocytes, wound healing, flavonoids
- MeSH terms
- Animals, Antioxidants, Female, Humans, Mice, Inbred C57BL, Proto-Oncogene Proteins, Quercetin, Radiation Injuries, Experimental, Random Allocation, Stomatitis, Up-Regulation, Mice, Polycomb Repressive Complex 1
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