Relationship between Vitamin D and Gestational Diabetes in Overweight or Obese Pregnant Women May Be Mediated by Adiponectin
Open accessAbstract
Scope: Maternal vitamin D deficiency has been implicated in adverse pregnancy outcomes. However, the association between vitamin D and inflammation, particularly adipokines, remains unexplored in pregnancy. Methods and results: In 102 overweight or obese pregnant women at high‐risk of gestational diabetes mellitus (GDM), we investigated relationships between maternal 25‐hydroxyvitamin D (25(OH)D) concentrations at 12–15 wk gestation (baseline) and serum lipids, inflammatory markers, novel adipokines (omentin‐1, visfatin, high molecular weight (HMW) adiponectin), and subsequent pregnancy outcomes (GDM, preeclampsia, preterm birth [PTB]). After adjustment for maternal factors (age, BMI, parity, ethnicity, and smoking status), baseline 25(OH)D concentrations were inversely associated with total cholesterol and triglycerides, and positively associated with HMW‐adiponectin. Higher baseline 25(OH)D concentrations were associated with decreased fasting and 1‐h post‐OGTT glucose and reduced risk of GDM at 26–28 wk, as well as with longer gestation and reduced risk of PTB upon additional adjustment for caesarean section. Adding HMW‐adiponectin to the multivariable models attenuated most associations, and HMW‐adiponectin was a significant predictor in the models. Conclusion: Our findings suggest that lower maternal 25(OH)D concentrations in overweight/obese pregnant women at high‐risk of GDM are associated with increased cardiometabolic risks during pregnancy and adverse pregnancy outcomes, and that these associations may be mediated by HMW‐adiponectin.
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Vitamin D deficiency during pregnancy is linked to adverse outcomes not only at birth but also for long-term health of both mothers and their children.
“It is now widely recognized that vitamin D deficiency during pregnancy is linked to adverse outcomes not only at birth but also for long-term health of both mothers and their children.”
From Maternal Overnutrition and Fetal Programming: Long-Term Metabolic, Cognitive, and Epigenetic Consequences (2026) · cites this paper as [142]
Low vitamin D levels in pregnant women, especially those who are obese, have been associated with disruptions in glucose and lipid metabolism, which may contribute to higher risks of diabetes and obesity later in life for their offspring.
“Low vitamin D levels in pregnant women, especially those who are obese, have been associated with disruptions in glucose and lipid metabolism, which may contribute to higher risks of diabetes and obesity later in life for their offspring.”
From Maternal Overnutrition and Fetal Programming: Long-Term Metabolic, Cognitive, and Epigenetic Consequences (2026) · cites this paper as [142]
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- Authors
- Mousa, A., Abell, S. K., Shorakae, S., Harrison, C. L., Naderpoor, N., Hiam, D., Moreno‐Asso, A., Stepto, N. K., Teede, H. J., & de Courten, B.
- Affiliations
- Monash University (AU)
- Victoria University (AU)
- Monash Centre for Health Research and Implementation (MCHRI) School of Public Health and Preventive Medicine Monash University Clayton, Melbourne Victoria Australia
- ORCID
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2017-08-23
- Volume
- 61
- Issue
- 11
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W2737313766
- Cited by
- 38
- References
- 3
- Citations by year
- 2026: 1 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 8 · 2017: 1
- FWCI
- 6.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Nutrition & Food Research (publishedVersion)
- PubMed (publishedVersion)
- Victoria University Research Repository (Victoria University) (submittedVersion)
- RMIT Research Repository (RMIT University Library) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Figshare (submittedVersion)
- Minerva Access (University of Melbourne) (submittedVersion)
- Funders
- Victoria University
- Monash University
- National Health and Medical Research Council
- Royal Australasian College of Physicians
- Foundation for High Blood Pressure Research
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- vitamin D, gestational diabetes mellitus, maternal obesity, adiponectin, 25-hydroxyvitamin D, adipokines, omentin-1, visfatin, preeclampsia, preterm birth, inflammation, cardiometabolic risk, mediation analysis, maternal serum lipids
- MeSH terms
- Adult, Calcifediol, Cardiovascular Diseases, Cross-Sectional Studies, Female, Hospitals, Teaching, Humans, Molecular Weight, Obesity, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Pregnancy Trimester, Second, Risk, Victoria, Vitamin D Deficiency, Cohort Studies, Biomarkers, 25-Hydroxyvitamin D 2, Body Mass Index, Diabetes, Gestational, Maternal Nutritional Physiological Phenomena, Overweight, Adiponectin
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