Is plasma 25(OH) D related to adipokines, inflammatory cytokines and insulin resistance in both a healthy and morbidly obese population?
Abstract
To analyse in a cohort of healthy subjects and in a group of morbidly obese patients, we studied the association amongst 25(OH) D and plasma concentrations of adipocytokines, inflammatory cytokines and insulin resistance. We also aimed to determine whether vitamin D-deficient patients showed a greater inflammatory profile. In the observational study that the authors conducted, plasma concentrations of 25(OH) D, leptin, resistin, adiponectin and interleukine-18 were determined in 134 healthy men and 127 women. In the population consisting of 44 patients with morbid obesity, plasma concentrations of 25(OH) D, leptin, resistin, adiponectin, interleukine-18, soluble tumor necrosis factor receptors 1 and 2 and C-reactive protein were analysed. In the healthy population, plasma 25(OH) D showed a negative correlation with body mass index, body fat, waist, hip circumference and with leptin. However, no significant associations were found amongst 25(OH) D and plasma concentrations of resistin, adiponectin or interleukine-18. Patients with vitamin D deficiency showed higher body mass index, fat mass percentage and higher leptin concentrations compared with subjects with normal 25(OH) D concentrations. In the morbidly obese subjects, 25(OH) D did not correlate with leptin, resistin, adiponectin, interleukine-18, soluble tumor necrosis factor receptors 1 and 2 or with C-reactive protein. In patients with morbid obesity, no differences were found in adipokines and inflammatory cytokines concentrations regarding 25(OH) D status. No associations were found either between 25(OH) D and plasma glucose and insulin resistance or with lipid profile. Plasma 25(OH) D concentrations are associated with adiposity markers but not with adipocytokines implicated in inflammation. This lack of association does not support a major role of 25(OH) D in the pro-inflammatory environment observed in morbidly obese subjects. In addition, subjects with vitamin D deficiency are not characterized by a greater inflammatory state.
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In human subjects, acute hyperglycaemia attenuates endothelium-dependent vasodilation.
“Indeed, alloxan diabetic rats are observed to have reduced NO levels in blood (656) , and in human subjects, acute hyperglycaemia attenuated endothelium-dependent vasodilation (657) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [657]
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Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
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- Authors
- Vilarrasa, N., Vendrell, J., Maravall, J., Elío, I., Solano, E., San José, P., García, I., Virgili, N., Soler, J., & Gómez, J. M.
- Affiliations
- Bellvitge University Hospital (ES)
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
- Corresponding author
- Gómez, José Manuel
- Venue
- Endocrine
- Published
- 2010-07-23
- Volume
- 38
- Issue
- 2
- Pages
- 235-242
- ISSN
- 0969-711X (ISSN-L)
- 1355-008X
- 1559-0100
- OpenAlex
- W2000093838
- Cited by
- 110
- References
- 57
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 6 · 2021: 3 · 2020: 7 · 2019: 4 · 2018: 10 · 2017: 9 · 2016: 9 · 2015: 7 · 2014: 13 · 2013: 15 · 2012: 12
- FWCI
- 7.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Endocrine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Instituto de Salud Carlos III
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- 25-hydroxyvitamin D, vitamin D deficiency, morbid obesity, adipokines, leptin, resistin, adiponectin, IL-18, inflammatory cytokines, insulin resistance, soluble tumor necrosis factor receptor, C-reactive protein, adiposity, inflammation
- MeSH terms
- Adult, Body Composition, C-Reactive Protein, Female, Humans, Hyperglycemia, Insulin Resistance, Male, Middle Aged, Obesity, Morbid, Vitamin D, Biomarkers, Comorbidity, Interleukin-18, Leptin, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Type II, Adiponectin, Resistin, Adipokines
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