Roasted Coffee Reduces β‐Amyloid Production by Increasing Proteasomal β‐Secretase Degradation in Human Neuroblastoma SH‐SY5Y Cells

Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein

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Caffeine protects Alzheimer’s mice against cognitive impairment and reduces brain β-amyloid production

Arendash, G. W., Schleif, W. S., Rezai-Zadeh, K. P., Jackson, E. K., Zacharia, L. C., Cracchiolo, J. R., Shippy, D. C., & Tan, J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.07.021 · Cited by 459 · see citing works

Midlife Coffee and Tea Drinking and the Risk of Late-Life Dementia: A Population-Based CAIDE Study

Eskelinen, M. H., Ngandu, T., Tuomilehto, J., Soininen, H., & Kivipelto, M. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-0920 · Cited by 428 · see citing works

Relationships of Dietary Patterns, Foods, and Micro- and Macronutrients with Alzheimer’s Disease and Late-Life Cognitive Disorders: A Systematic Review

Solfrizzi, V., Custodero, C., Lozupone, M., Imbimbo, B. P., Valiani, V., Agosti, P., Schilardi, A., D’Introno, A., Montagna, M. L., Calvani, M., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170248 · Cited by 351 · see citing works

Caffeine Reverses Cognitive Impairment and Decreases Brain Amyloid-β Levels in Aged Alzheimer's Disease Mice

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cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins

Lokireddy, S., Kukushkin, N. V., & Goldberg, A. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522332112 · Cited by 222 · see citing works

Caffeine and Coffee as Therapeutics Against Alzheimer's Disease

Arendash, G. W., & Cao, C. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091249 · Cited by 202 · see citing works

Caffeine Intake and Dementia: Systematic Review and Meta-Analysis

Santos, C. D., Costa, J. N., dos Santos, J. P., Carneiro, A. V., & Lunet, N. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091387 · Cited by 193 · see citing works

Cleavage of Alzheimer's Amyloid Precursor Protein (APP) by Secretases Occurs after O-Glycosylation of APP in the Protein Secretory Pathway

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The Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer’s Disease and Spinal Cord Injury

Gong, B., Radulovic, M., Figueiredo‐Pereira, M. E., & Cardozo, C. P. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00004 · Cited by 167 · see citing works

BACE Is Degraded via the Lysosomal Pathway

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Relationship between amyloid-beta and the ubiquitin–proteasome system in Alzheimer’s disease

Hong, L., Huang, H., & Jiang, Z.-F. (2013) · Neurological Research · doi:10.1179/1743132813y.0000000288 · Cited by 159 · see citing works

Ubiquitin pathways in neurodegenerative disease

Atkin, G., & Paulson, H. L. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00063 · Cited by 136 · see citing works

The Role and Therapeutic Targeting of α-, β- and γ-Secretase in Alzheimer's Disease

MacLeod, R., Hillert, E., Cameron, R. T., & Baillie, G. S. (2015) · Future Science OA · doi:10.4155/fso.15.9 · Cited by 131 · see citing works

Crude caffeine reduces memory impairment and amyloid β1–42 levels in an Alzheimer’s mouse model

Chu, Y.-F., Chang, W.-H., Black, R. M., Liu, J.-R., Sompol, P., Chen, Y., Wei, H., Zhao, Q., & Cheng, I. H. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.04.148 · Cited by 106 · see citing works

β‐Site APP‐cleaving enzyme 1 trafficking and Alzheimer’s disease pathogenesis

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BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology

Peters, F., Salihoglu, H., Rodrigues, E. F., Herzog, É., Blume, T., Filser, S., Dorostkar, M. M., Shimshek, D. R., Brose, N., Neumann, U., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-017-1804-9 · Cited by 86 · see citing works

Caffeine induces beneficial changes in PKA signaling and JNK and ERK activities in the striatum and cortex of Alzheimer's transgenic mice

Zeitlin, R., Patel, S., Burgess, S., Arendash, G. W., & Echeverrı́a, V. (2011) · Brain Research · doi:10.1016/j.brainres.2011.08.036 · Cited by 82 · see citing works

Caffeine Synergizes with Another Coffee Component to Increase Plasma GCSF: Linkage to Cognitive Benefits in Alzheimer's Mice

Cao, C., Wang, L., Lin, X., Mamcarz, M. B., Zhang, C., Bai, G., Nong, J., Sussman, S., & Arendash, G. W. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110110 · Cited by 75 · see citing works

BACE1 Inhibitor Lanabecestat (AZD3293) in a Phase 1 Study of Healthy Japanese Subjects: Pharmacokinetics and Effects on Plasma and Cerebrospinal Fluid Aβ Peptides

Sakamoto, K., Matsuki, S., Matsuguma, K., Yoshihara, T., Uchida, N., Azuma, F., Russell, M., Hughes, G., Haeberlein, S. B., Alexander, R., et al. (2017) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.950 · Cited by 62 · see citing works

Coffee, but not caffeine, has positive effects on cognition and psychomotor behavior in aging

Shukitt‐Hale, B., Miller, M. G., Chu, Y., Lyle, B. J., & Joseph, J. A. (2013) · AGE · doi:10.1007/s11357-012-9509-4 · Cited by 58 · see citing works

Role of Orexin System in Obesity

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Beta-secretase inhibitors in phase I and phase II clinical trials for Alzheimer’s disease

Moussa, C. (2017) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2017.1369527 · Cited by 46 · see citing works

Alzheimer's therapy targeting the β-secretase enzyme BACE1: Benefits and potential limitations from the perspective of animal model studies.

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Gas Chromatography Time-Of-Flight Mass Spectrometry (GC-TOF-MS)-Based Metabolomics for Comparison of Caffeinated and Decaffeinated Coffee and Its Implications for Alzheimer’s Disease

Chang, K. L., & Ho, P. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104621 · Cited by 41 · see citing works

Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation

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The Chemopreventive Effects of Chlorogenic Acids, Phenolic Compounds in Coffee, against Inflammation, Cancer, and Neurological Diseases

Murai, T., & Matsuda, S. (2023) · Molecules · doi:10.3390/molecules28052381 · Cited by 93 · see citing works

Coffee intake and decreased amyloid pathology in human brain

Kim, J. W., Byun, M. S., Yi, D., Lee, J. H., Jeon, S. Y., Jung, G., Lee, H. N., Sohn, B. K., Lee, J.-Y., Kim, Y. K., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0604-5 · Cited by 86 · see citing works

Coffee and Lower Risk of Type 2 Diabetes: Arguments for a Causal Relationship

Kolb, H., Martin, S., & Kempf, K. (2021) · Nutrients · doi:10.3390/nu13041144 · Cited by 86 · see citing works

Beneficial Effects of Epigallocatechin-3-O-Gallate, Chlorogenic Acid, Resveratrol, and Curcumin on Neurodegenerative Diseases

Fukutomi, R., Ohishi, T., Koyama, Y., Pervin, M., Nakamura, Y., & Isemura, M. (2021) · Molecules · doi:10.3390/molecules26020415 · Cited by 73 · see citing works

Potential of Caffeine in Alzheimer’s Disease—A Review of Experimental Studies

Londzin, P., Zamora, M., Kąkol, B., Taborek, A., & Folwarczna, J. (2021) · Nutrients · doi:10.3390/nu13020537 · Cited by 71 · see citing works

Methylxanthines and Neurodegenerative Diseases: An Update

Janitschke, D., Lauer, A. A., Bachmann, C. M., Grimm, H. S., Hartmann, T., & Grimm, M. O. W. (2021) · Nutrients · doi:10.3390/nu13030803 · Cited by 56 · see citing works

The Regulatory effect of chlorogenic acid on gut-brain function and its mechanism: A systematic review

Zeng, L., Xiang, R., Fu, C.-Y., Qu, Z., & Liu, C. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112831 · Cited by 54 · see citing works

Pyrocatechol, a component of coffee, suppresses LPS-induced inflammatory responses by inhibiting NF-κB and activating Nrf2

Funakoshi‐Tago, M., Nonaka, Y., Tago, K., Takeda, M., Ishihara, Y., Sakai, A., Matsutaka, M., Kobata, K., & Tamura, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-59380-x · Cited by 53 · see citing works

Proteasome Subunits Involved in Neurodegenerative Diseases

Fernández-Cruz, I., & Reynaud, E. (2020) · Archives of Medical Research · doi:10.1016/j.arcmed.2020.09.007 · Cited by 48 · see citing works

Neural Protective Effects of Millet and Millet Polyphenols on High-Fat Diet-Induced Oxidative Stress in the Brain

Li, S., Xian, F., Guan, X., Huang, K., Yu, W., & Liu, D. (2020) · Plant Foods for Human Nutrition · doi:10.1007/s11130-020-00802-6 · Cited by 42 · see citing works

Panaxadiol inhibits synaptic dysfunction in Alzheimer's disease and targets the Fyn protein in APP/PS1 mice and APP-SH-SY5Y cells

Liang, X., Yao, Y., Lin, Y., Kong, L., Xiao, H., Shi, Y., & Yang, J. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.02.012 · Cited by 35 · see citing works

Effect of Caffeine and Other Methylxanthines on Aβ-Homeostasis in SH-SY5Y Cells

Janitschke, D., Nelke, C., Lauer, A. A., Regner-Nelke, L., Winkler, J., Thiel, A., Grimm, H. S., Hartmann, T., & Grimm, M. O. W. (2019) · Biomolecules · doi:10.3390/biom9110689 · Cited by 33 · see citing works

Impact of coffee intake on human aging: Epidemiology and cellular mechanisms

Lopes, C. R., & Cunha, R. A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102581 · Cited by 26 · see citing works

Effect of a Lens Protein in Low-Temperature Culture of Novel Immortalized Human Lens Epithelial Cells (iHLEC-NY2)

Yamamoto, N., Takeda, S., Hatsusaka, N., Hiramatsu, N., Nagai, N., Deguchi, S., Nakazawa, Y., Takata, T., Kodera, S., Hirata, A., et al. (2020) · Cells · doi:10.3390/cells9122670 · Cited by 18 · see citing works

Neuroprotective Effects of Cilomilast and Chlorogenic Acid Against Scopolamine-Induced Memory Deficits via Modulation of the cAMP/PKA–CREB–BDNF Pathway

Mosalam, E. M., Atya, S. M., Mesbah, N. M., Allam, S., & Mehanna, E. T. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073108 · Cited by 16 · see citing works

Aloe vera and Fermented Extracts Exhibit an Anti-Inflammatory Effect on Human Glioblastoma/Astrocytoma U373 MG Cells

Tornero-Martínez, A., Silva‐Lucero, M., Cano-Sampedro, E., Ramón‐Gallegos, E., Perez‐Cruz, C., Pérez-Grijalva, B., & Mora‐Escobedo, R. (2022) · Plant Foods for Human Nutrition · doi:10.1007/s11130-022-00957-4 · Cited by 15 · see citing works

The Relationship between Beverages Consumption and Cognitive Impairment in Middle-Aged and Elderly Chinese Population

Jiang, X., Cui, L., Huang, L., Guo, Y., Huang, G.-Z., & Guo, Q. (2023) · Nutrients · doi:10.3390/nu15102309 · Cited by 14 · see citing works

Effect of Inhibiting Butyrylcholinesterase Activity Using Fractionated Coffee Extracts Digested In Vitro in Gastrointestinal Tract: Docking Simulation and Calorimetric and Studies

Grzelczyk, J., Szwajgier, D., Baranowska‐Wójcik, E., Pérez‐Sánchez, H., Carmena‐Bargueño, M., Sosnowska, B., & Budryn, G. (2023) · Nutrients · doi:10.3390/nu15102366 · Cited by 11 · see citing works

Molecular Basis of Preventive Effects of Habitual Coffee Intake against Chronic Diseases

Tamura, H. (2020) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.20-00150 · Cited by 7 · see citing works

Coffee extracts effectively inhibit the formation of α-chymotrypsin amyloid-like fibrils in aqueous ethanol in vitro

Kotormán, M., & Bedő, V. A. (2020) · Biologia Futura · doi:10.1007/s42977-020-00006-8 · Cited by 3 · see citing works

Celastrol promotes apoptotic cell death in children neuroblastoma cells through caspases dependent pathway.

Yang, Y., Zhang, A., & Anmao, L. I. (2022) · PubMed Central · doi:10.19852/j.cnki.jtcm.20220425.002 · Cited by 3 · see citing works

Molecular Basis of Preventive Effects of Habitual Coffee Intake against Chronic Diseases

Tamura, H. (2020) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.20-00150 · Cited by 7 · see citing works

Coffee reduces BACE1 expression by activation of proteasomal degradation in human neuroblastoma cells.

Fukuyama, K., Kakio, S., Kobata, K., Suzuki, T., Tago, M., & Tamura, H. (2017) · The Japanese Biochemical Society/The Molecular Biology Society of Japan

Phenylindanes in Brewed Coffee Inhibit Amyloid-Beta and Tau Aggregation

Mancini, R. S., Wang, Y., & Weaver, D. F. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00735 · Cited by 75 · see citing works

F1‐01‐01: Coffee protects against in vivo Abeta toxicity via activation of the skn‐1 (Nrf2) detoxification pathway

Link, C. D., Dostal, V., & Roberts, C. M. (2010) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.05.170

Genetic Mechanisms of Coffee Extract Protection in aCaenorhabditis elegansModel of β-Amyloid Peptide Toxicity

Dostal, V., Roberts, C. M., & Link, C. D. (2010) · Genetics · doi:10.1534/genetics.110.120436 · Cited by 112 · see citing works