Coffee intake and decreased amyloid pathology in human brain
Open accessAbstract
Several epidemiological and preclinical studies supported the protective effect of coffee on Alzheimer’s disease (AD). However, it is still unknown whether coffee is specifically related with reduced brain AD pathologies in human. Hence, this study aims to investigate relationships between coffee intake and in vivo AD pathologies, including cerebral beta-amyloid (Aβ) deposition, the neurodegeneration of AD-signature regions, and cerebral white matter hyperintensities (WMH). A total of 411 non-demented older adults were included. Participants underwent comprehensive clinical assessment and multimodal neuroimaging including [11 C] Pittsburgh compound B-positron emission tomography (PET), [18 F] fluorodeoxyglucose PET, and magnetic resonance imaging scans. Lifetime and current coffee intake were categorized as follows: no coffee or <2 cups/day (reference category) and ≥2 cups/day (higher coffee intake). Lifetime coffee intake of ≥2 cups/day was significantly associated with a lower Aβ positivity compared to coffee intake of <2 cups/day, even after controlling for potential confounders. In contrast, neither lifetime nor current coffee intake was not related to hypometabolism, atrophy of AD-signature region, and WMH volume. The findings suggest that higher lifetime coffee intake may contribute to lowering the risk of AD or related cognitive decline by reducing pathological cerebral amyloid deposition.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Although caffeine reduces the risk for AD in both men and women, the protective effect seems to be greater in women.
“Although caffeine reduces the risk for AD [68, 69] in both men and women, the protective effect seems to be greater in women [70].”
From Sex-specific DNA methylation differences in Alzheimer’s disease pathology (2021) · cites this paper as [69]
Citation [70] is attached to the claim that the protective effect is greater in women. In the Results section on moderating effects (page unavailable), the paper reports no significant interaction between gender and lifetime coffee intake for amyloid positivity. It studied coffee intake rather than isolating caffeine’s effect. (LLM, conf=0.88)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882 · see citing works
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806 · see citing works
Jack, C. R., Knopman, D. S., Jagust, W. J., Petersen, R. C., Weiner, M. W., Aisen, P. S., Shaw, L. M., Vemuri, P., Wiste, H. J., Weigand, S. D., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70291-0 · Cited by 4,396 · see citing works
Lindsay, J. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf074 · Cited by 1,261 · see citing works
Apolipoprotein E genotyping by one-stage PCR
Wenham, P. R., Price, W. H., & Blundell, G. (1991) · The Lancet · doi:10.1016/0140-6736(91)92823-k · Cited by 1,070 · see citing works
Reiman, E. M., Chen, K., Liu, X., Bandy, D., Yu, M., Lee, W., Ayutyanont, N., Keppler, J., Reeder, S. A., Langbaum, J. B. S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900345106 · Cited by 785 · see citing works
Association of coffee and caffeine intake with the risk of Parkinson disease
Ross, G. W. (2000) · JAMA · doi:10.1001/jama.283.20.2674 · Cited by 778 · see citing works
Lee, J. H., Lee, K. U., Lee, D. Y., Kim, K. W., Jhoo, J. H., Kim, J. H., Lee, K. H., Kim, S. Y., Han, S., & Woo, J. I. (2002) · The Journals of Gerontology Series B · doi:10.1093/geronb/57.1.p47 · Cited by 774 · see citing works
Self-citationAssociation Between Midlife Vascular Risk Factors and Estimated Brain Amyloid Deposition
Gottesman, R. F., Schneider, A. L. C., Zhou, Y., Coresh, J., Green, E., Gupta, N., Knopman, D. S., Mintz, A., Rahmim, A., Sharrett, A. R., et al. (2017) · JAMA · doi:10.1001/jama.2017.3090 · Cited by 650 · see citing works
Arendash, G. W., Schleif, W. S., Rezai-Zadeh, K. P., Jackson, E. K., Zacharia, L. C., Cracchiolo, J. R., Shippy, D. C., & Tan, J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.07.021 · Cited by 459 · see citing works
Midlife Coffee and Tea Drinking and the Risk of Late-Life Dementia: A Population-Based CAIDE Study
Eskelinen, M. H., Ngandu, T., Tuomilehto, J., Soininen, H., & Kivipelto, M. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-0920 · Cited by 428 · see citing works
A normative study of the CERAD neuropsychological assessment battery in the Korean elderly
LEE, D. Y., Lee, K. U., Lee, H., Kim, K. W., Jhoo, J. H., Kim, S. Y., Yoon, J. C., WOO, S. I., Ha, J. B., & Woo, J. I. (2004) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617704101094 · Cited by 407 · see citing works
Self-citationRelation of cognitive activity to risk of developing Alzheimer disease
Wilson, R. S., Scherr, P. A., Schneider, J. A., Tang, Y., & Bennett, D. A. (2007) · Neurology · doi:10.1212/01.wnl.0000271087.67782.cb · Cited by 400 · see citing works
Jack, C. R., Wiste, H. J., Weigand, S. D., Rocca, W. A., Knopman, D. S., Mielke, M. M., Lowe, V. J., Senjem, M. L., Gunter, J. L., Preboske, G. M., et al. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70194-2 · Cited by 358 · see citing works
Early and late life cognitive activity and cognitive systems in old age
WILSON, R. S., BARNES, L. L., KRUEGER, K. R., HOGANSON, G., BIENIAS, J. L., & BENNETT, D. A. (2005) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617705050459 · Cited by 355 · see citing works
Coffee, caffeine, and cardiovascular disease in men.
Grobbee, D. E., Rimm, E. B., Giovannucci, E., Colditz, G., Stampfer, M., & Willett, W. (1990) · New England Journal of Medicine · doi:10.1056/nejm199010113231504 · Cited by 322 · see citing works
Arendash, G. W., Mori, T., Cao, C., Mamcarz, M., Runfeldt, M., Dickson, A., Rezai-Zadeh, K., Tan, J., Citron, B. A., Lin, X., et al. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1087 · Cited by 308 · see citing works
Memory impairment, but not cerebrovascular disease, predicts progression of MCI to dementia
DeCarli, C. S., Mungas, D., Harvey, D., Reed, B., Weiner, M. W., Chui, H. C., & Jagust, W. J. (2004) · Neurology · doi:10.1212/01.wnl.0000130531.90205.ef · Cited by 273 · see citing works
Caffeine as a Protective Factor in Dementia and Alzheimer's Disease
Eskelinen, M. H., & Kivipelto, M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1404 · Cited by 261 · see citing works
van Gelder, B. M., Buijsse, B., Tijhuis, M., Kalmijn, S., Giampaoli, S., Nissinen, A., & Kromhout, D. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602495 · Cited by 228 · see citing works
Ding, M., Satija, A., Bhupathiraju, S. N., Hu, Y., Sun, Q., Han, J., López‐García, E., Willett, W. C., van Dam, R. M., & Hu, F. B. (2015) · Circulation · doi:10.1161/circulationaha.115.017341 · Cited by 203 · see citing works
Caffeine Suppresses Amyloid-β Levels in Plasma and Brain of Alzheimer's Disease Transgenic Mice
Cao, C., Cirrito, J. R., Lin, X., Wang, L., Verges, D. K., Dickson, A., Mamcarz, M. B., Zhang, C., Mori, T., Arendash, G. W., et al. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1071 · Cited by 195 · see citing works
Habitual Coffee Consumption and Risk of Heart Failure: A Dose-Response Meta-Analysis
Mostofsky, E., Rice, M. S., Levitan, E. B., & Mittleman, M. A. (2012) · Circulation: Heart Failure · doi:10.1161/circheartfailure.112.967299 · Cited by 185 · see citing works
Kim, J. Y., Park, J. H., Lee, J. J., Huh, Y., Lee, S. B., Han, S. K., Choi, S. W., Lee, D. Y., Kim, K. W., & Woo, J. I. (2008) · Psychiatry Investigation · doi:10.4306/pi.2008.5.4.232 · Cited by 179 · see citing works
Self-citationPark, J., Han, S.-H., Yi, D., Byun, M. S., Lee, J. H., Jang, S. S., Ko, K., Jeon, S. Y., Lee, Y., Kim, Y. K., et al. (2018) · Brain · doi:10.1093/brain/awy347 · Cited by 178 · see citing works
Self-citationInhibition of protein misfolding and aggregation by natural phenolic compounds
Dhouafli, Z., Cuanalo-Contreras, K., Hayouni, E. A., Mays, C. E., Soto, C. A., & Moreno‐González, I. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2872-2 · Cited by 174 · see citing works
Turunc Bayrakdar, E., Uyanikgil, Y., Kanit, L., Koylu, E., & Yalcin, A. (2014) · Free Radical Research · doi:10.3109/10715762.2013.857018 · Cited by 169 · see citing works
Loftfield, E., Freedman, N. D., Dodd, K. W., Vogtmann, E., Xiao, Q., Sinha, R. R., & Graubard, B. I. (2016) · Journal of Nutrition · doi:10.3945/jn.116.233940 · Cited by 161 · see citing works
Effects of coffee on type 2 diabetes mellitus
Akash, M. S. H., Rehman, K., & Chen, S. (2013) · Nutrition · doi:10.1016/j.nut.2013.11.020 · Cited by 152 · see citing works
Nuhu, A. A. (2014) · ISRN Nutrition · doi:10.1155/2014/384230 · Cited by 145 · see citing works
Amyloid imaging as a biomarker for cerebral β-amyloidosis and risk-prediction for Alzheimer dementia
Klunk, W. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.09.006 · Cited by 134 · see citing works
Coffee Intake in Midlife and Risk of Dementia and its Neuropathologic Correlates
Gelber, R. P., Petrovitch, H., Masaki, K. H., Ross, G. W., & White, L. R. (2011) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-101428 · Cited by 133 · see citing works
The Chemical Components of Coffee
Spiller, M. A. (2019) · CRC Press eBooks · doi:10.1201/9780429126789-6 · Cited by 124 · see citing works
Byun, M. S., Yi, D., Lee, J. H., Choe, Y. M., Sohn, B. K., Lee, J., Choi, H. J., Baek, H., Kim, Y. K., Lee, Y., et al. (2017) · Psychiatry Investigation · doi:10.4306/pi.2017.14.6.851 · Cited by 116 · see citing works
Self-citationLucas, M., O’Reilly, E. J., Pan, A., Mirzaei, F., Willett, W. C., Okereke, O. I., & Ascherio, A. (2014) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2013.795243 · Cited by 103 · see citing works
Arab, L., Biggs, M. L., O'Meara, E. S., Longstreth, W. T., Crane, P. K., & Fitzpatrick, A. L. (2011) · Journal of Alzheimer's Disease · doi:10.3233/jad-2011-110431 · Cited by 98 · see citing works
Coffee Consumption and Risk of Stroke in Women
Larsson, S. C., Virtamo, J., & Wolk, A. (2011) · Stroke · doi:10.1161/strokeaha.110.603787 · Cited by 93 · see citing works
Coffee and cancer risk: A meta-analysis of prospective observational studies
Wang, A., Wang, S., Zhu, C., Huang, H., Wu, L., Wan, X., Yang, X., Zhang, H., Miao, R., He, L., et al. (2016) · Scientific Reports · doi:10.1038/srep33711 · Cited by 85 · see citing works
Coffee and acute ischemic stroke onset: The Stroke Onset Study
Mostofsky, E., Schlaug, G., Mukamal, K. J., Rosamond, W. D., & Mittleman, M. A. (2010) · Neurology · doi:10.1212/wnl.0b013e3181fb443d · Cited by 75 · see citing works
Cao, C., Wang, L., Lin, X., Mamcarz, M. B., Zhang, C., Bai, G., Nong, J., Sussman, S., & Arendash, G. W. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110110 · Cited by 75 · see citing works
Caffeine and Cognitive Decline in Elderly Women at High Vascular Risk
Vercambre, M., Berr, C., Ritchie, K. A., & Kang, J. H. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-122371 · Cited by 66 · see citing works
Driscoll, I., Shumaker, S. A., Snively, B. M., Margolis, K. L., Manson, J. E., Vitolins, M. Z., Rossom, R. C., & Espeland, M. A. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glw078 · Cited by 55 · see citing works
Tsai, J., Peng, S., Chen, Y., Wang, K.-W., Li, C.-H., Wang, J. Y., Chen, C.-J., Lin, H.-J., Smith, E. E., Wu, H.-K., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104011 · Cited by 47 · see citing works
Ritchie, K., Artero, S., Portet, F., Brickman, A., Muraskin, J., Beanino, E., Ancelin, M.-L., & Carrière, I. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-1387 · Cited by 45 · see citing works
Li, S., Geiger, N. H., Soliman, M. L., Hui, L., Geiger, J. D., & Chen, X. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142223 · Cited by 35 · see citing works
Ko, K., Byun, M. S., Yi, D., Lee, J. H., Kim, C. H., & Lee, D. Y. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00070 · Cited by 31 · see citing works
Self-citationValidation and reproducibility of an Australian caffeine food frequency questionnaire
Watson, E. J., Kohler, M. J., Banks, S., & Coates, A. M. (2017) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2016.1268102 · Cited by 26 · see citing works
Fukuyama, K., Kakio, S., Nakazawa, Y., Kobata, K., Funakoshi‐Tago, M., Suzuki, T., & Tamura, H. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800238 · Cited by 22 · see citing works
Moon, S. W., Byun, M. S., Yi, D., Lee, J. H., Jeon, S. Y., Lee, Y., Kee, B. S., & Lee, D. Y. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly157 · Cited by 10 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Dominguez, L. J., Veronese, N., Vernuccio, L., Catanese, G., Inzerillo, F., Salemi, G., & Barbagallo, M. (2021) · Nutrients · doi:10.3390/nu13114080 · Cited by 433 · see citing works
Marzia Perluigi, A., Domenico, F. D., & Butterfield, D. A. (2023) · Physiological Reviews · doi:10.1152/physrev.00030.2022 · Cited by 306 · see citing works
Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics
Migliore, L., & Coppedè, F. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00714-w · Cited by 217 · see citing works
Feng, J., Zheng, Y., Guo, M., Arés, I., Martínez, M., López-Torres, B., Martínez‐Larrañaga, M., Wang, X., Anadón, A., & Martínez, M. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.07.010 · Cited by 181 · see citing works
Oxidative Stress and Cognitive Decline: The Neuroprotective Role of Natural Antioxidants
Franzoni, F., Scarfò, G., Guidotti, S., Fusi, J., Асомов, М. И., & Pruneti, C. A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.729757 · Cited by 136 · see citing works
Sanders, O. D., & Rajagopal, L. (2020) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-200191 · Cited by 115 · see citing works
Amato, A., Terzo, S., & Mulè, F. (2019) · Antioxidants · doi:10.3390/antiox8120608 · Cited by 107 · see citing works
APOE Genotype and Alzheimer’s Disease: The Influence of Lifestyle and Environmental Factors
Angelopoulou, E., Paudel, Y. N., Papageorgiou, S. G., & Piperi, C. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00295 · Cited by 105 · see citing works
In Pursuit of Healthy Aging: Effects of Nutrition on Brain Function
Melzer, T. M., Manosso, L. M., Yau, S., Gil‐Mohapel, J., & Brocardo, P. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22095026 · Cited by 90 · see citing works
Fukutomi, R., Ohishi, T., Koyama, Y., Pervin, M., Nakamura, Y., & Isemura, M. (2021) · Molecules · doi:10.3390/molecules26020415 · Cited by 73 · see citing works
Neuroprotective Effect of Caffeine in Alzheimer’s Disease
Yelanchezian, Y. M. M., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2022) · Molecules · doi:10.3390/molecules27123737 · Cited by 64 · see citing works
Sex-specific DNA methylation differences in Alzheimer’s disease pathology
Zhang, L., Young, J. I., Gomez, L., Silva, T. C., Schmidt, M. A., Cai, J., Chen, X., Martin, E. R., & Wang, L. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01177-8 · Cited by 58 · see citing works
Tau pathology epigenetically remodels the neuron-glial cross-talk in Alzheimer’s disease
Zhou, L., Liu, D., Kang, H., Lu, L., Huang, H., Ai, W.-Q., Zhou, Y., Deng, M., Li, H., Liu, Z., et al. (2023) · Science Advances · doi:10.1126/sciadv.abq7105 · Cited by 58 · see citing works
Methylxanthines and Neurodegenerative Diseases: An Update
Janitschke, D., Lauer, A. A., Bachmann, C. M., Grimm, H. S., Hartmann, T., & Grimm, M. O. W. (2021) · Nutrients · doi:10.3390/nu13030803 · Cited by 56 · see citing works
Larsson, S. C., Woolf, B. A. R., & Gill, D. (2022) · Nutrients · doi:10.3390/nu14091697 · Cited by 55 · see citing works
Jurcău, A. (2021) · Nutrients · doi:10.3390/nu13020282 · Cited by 55 · see citing works
Gardener, S. L., Rainey‐Smith, S. R., Villemagne, V. L., Fripp, J., Doré, V., Bourgeat, P., Taddei, K., Fowler, C. J., Masters, C. L., Maruff, P. T., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.744872 · Cited by 47 · see citing works
Torabynasab, K., Shahinfar, H., Payandeh, N., & Jazayeri, S. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1051444 · Cited by 42 · see citing works
Adenosine receptor signalling in Alzheimer’s disease
Trinh, P. N. H., Baltos, J., Hellyer, S. D., May, L. T., & Gregory, K. J. (2022) · Purinergic Signalling · doi:10.1007/s11302-022-09883-1 · Cited by 42 · see citing works
Talebi, M., Kakouri, E., Talebi, M., Tarantilis, P. Α., Farkhondeh, T., İlgün, S., Pourbagher‐Shahri, A. M., & Samarghandian, S. (2021) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2021.1923479 · Cited by 39 · see citing works
Stazi, M., Lehmann, S., Sakib, M. S., Pena‐Centeno, T., Büschgens, L., Fischer, A., Weggen, S., & Wirths, O. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04062-8 · Cited by 39 · see citing works
Insulin Resistance as a Common Link Between Current Alzheimer’s Disease Hypotheses
Alves, S. S., da Silva-Júnior, R. M. P., Servilha‐Menezes, G., Homolak, J., Šalković‐Petrišić, M., & Garcia‐Cairasco, N. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210234 · Cited by 38 · see citing works
More than Just Antioxidants: Redox-Active Components and Mechanisms Shaping Redox Signalling Network
Kuczyńska, M., Jakubek, P., & Bartoszek, A. (2022) · Antioxidants · doi:10.3390/antiox11122403 · Cited by 36 · see citing works
Neuroprotective properties of coffee: An update
Carneiro, S. M., Oliveira, M. B. P. P., & Alves, R. C. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.04.052 · Cited by 36 · see citing works
Wasim, S., Kukkar, V., Awad, V. M., Sakhamuru, S., & Malik, B. H. (2020) · Cureus · doi:10.7759/cureus.9578 · Cited by 35 · see citing works
Andrade, S., Loureiro, J. A., & Pereira, M. D. C. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.08.198 · Cited by 33 · see citing works
The Epigenetic Effects of Coffee
Ding, Q., Xu, Y., & Lau, A. T. Y. (2023) · Molecules · doi:10.3390/molecules28041770 · Cited by 33 · see citing works
Song, X., Singh, M. V., Lee, K. E., Vinayagam, R., & Kang, S. G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212003 · Cited by 40 · see citing works
The role of adenosine A2A receptors in Alzheimer's disease and tauopathies
Launay, A., Nebie, O., Shankara, J. V., Lebouvier, T., Buée, L., Faivre, É., & Blum, D. L. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109379 · Cited by 28 · see citing works
Impact of coffee intake on human aging: Epidemiology and cellular mechanisms
Lopes, C. R., & Cunha, R. A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102581 · Cited by 26 · see citing works
Therapeutic approaches of nutraceuticals in the prevention of Alzheimer's disease
Pandey, S. N., Singh, G., Semwal, B. C., Gupta, G., Alharbi, K. S., Almalki, W. H., Albratty, M., Najmi, A., & Meraya, A. M. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14426 · Cited by 22 · see citing works
Faria, W. C. S., de Oliveira, M. G., da Conceição, E. C., da Silva, V. B., Veggi, N., Converti, A., de Barros, W. M., da Silva, M. F., & Bragagnolo, N. (2020) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2020.106004 · Cited by 21 · see citing works
Emerging phosphodiesterase inhibitors for treatment of neurodegenerative diseases
Xiang, Y., Naik, S. G., Zhao, L., Shi, J., & Ke, H. (2024) · Medicinal Research Reviews · doi:10.1002/med.22017 · Cited by 21 · see citing works
Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice
Gómez‐Murcia, V., Launay, A., Carvalho, K., Burgard, A., Mériaux, C., Caillierez, R., Eddarkaoui, S., Kilinc, D., Siedlecki‐Wullich, D., Besegher, M., et al. (2024) · Brain · doi:10.1093/brain/awae113 · Cited by 20 · see citing works
Tapias, V., González-Andrés, P., Fernández-Peña, L., Barbero, A., Núñez, L., & Villalobos, C. (2023) · Antioxidants · doi:10.3390/antiox12061282 · Cited by 20 · see citing works
Wang, J.-S., Tsai, P.-H., Tseng, K.-F., Chen, F.-Y., Yang, W., & Shen, M. (2021) · Antioxidants · doi:10.3390/antiox10101519 · Cited by 20 · see citing works
Blum, D., Cailliau, É., Béhal, H., Vidal, J., Delaby, C., Buée, L., Allinquant, B., Gabelle, A., Bombois, S., Lehmann, S., et al. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.14169 · Cited by 11 · see citing works
Jiang, X., Cui, L., Huang, L., Guo, Y., Huang, G.-Z., & Guo, Q. (2023) · Nutrients · doi:10.3390/nu15102309 · Cited by 14 · see citing works
Alzheimer, Parkinson, dementia, and phytochemicals: insight review
Başak, C. A. N., & Şanlıer, N. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2299340 · Cited by 14 · see citing works
Kan, Z., Wang, Y., Chen, Q., Tang, X., Thompson, H. J., Huang, J., Zhang, J., Gao, F., Shen, Y., & Wan, X. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100626 · Cited by 14 · see citing works
Anti‐Alzheimer's disease potential of Arabian coffee versus Date palm seed extract in male rats
Zidan, N. S., Omran, A. M. E., Rezk, S. M., Atteia, H. H., & Sakran, M. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.14017 · Cited by 13 · see citing works
Gomaa, A. A., Farghaly, H. S. M., Ahmed, A. M., El‐Mokhtar, M. A., & Hemida, F. K. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174873 · Cited by 12 · see citing works
Stazi, M., Zampar, S., Klafki, H., Meyer, T., & Wirths, O. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032155 · Cited by 12 · see citing works
Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study
Mayer, C., Nägele, F. L., Petersen, M., Schell, M., Aarabi, G., Beikler, T., Borof, K., Frey, B. M., Nikorowitsch, J., Senftinger, J., et al. (2023) · Nutrients · doi:10.3390/nu15030674 · Cited by 10 · see citing works
Association of Caffeine Consumption and Brain Amyloid Positivity in Cognitively Normal Older Adults
Zheng, Y., Sun, J., Shi, L., Su, S., Chen, X., Wang, Q., Huang, Y., Wang, Y., Zhu, X.-M., Que, J., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-220591 · Cited by 10 · see citing works
Habitual coffee consumption and risk of dementia in older persons: modulation by CYP1A2 polymorphism
Lefèvre‐Arbogast, S., Helmer, C., Berr, C., Debette, S., & Samieri, C. (2023) · European Journal of Epidemiology · doi:10.1007/s10654-023-01060-x · Cited by 10 · see citing works
Moon, S. W., Byun, M. S., Yi, D., Lee, J. H., Jeon, S. Y., Lee, Y., Kee, B. S., & Lee, D. Y. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly157 · Cited by 10 · see citing works
Self-citationMedvedeva, M. V., Kitsilovskaya, K. N. A., Stroylova, Y. Y., Sevostyanova, I. A., Saboury, A. A., & Muronetz, V. I. (2022) · Biomedicines · doi:10.3390/biomedicines10092255 · Cited by 10 · see citing works
Zhuang, Y., Wang, X., Zhang, X., Fang, Q., Zhang, X., & Song, Y. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1218592 · Cited by 9 · see citing works
Carbone, M. G., Pagni, G., Tagliarini, C., Maremmani, I., & Maremmani, A. G. I. (2025) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph22081171 · Cited by 9 · see citing works
Ismail, A., Al‐kuraishy, H. M., Al-Gareeb, A. I., Albuhadily, A. K., Alkazmi, L. M., Albukhari, A. F., Shokr, M. M., Alexiou, A. T., Papadakis, M., & Batiha, G. E. (2026) · Purinergic Signalling · doi:10.1007/s11302-025-10114-6 · Cited by 8 · see citing works
Screening neuroprotective compounds in herpes-induced Alzheimer's disease cell and 3D tissue models
Silveira, I. A., Mullis, A. S., Cairns, D. M., Shevzov-Zebrun, A., Whalen, J., Galuppo, A., Walsh, K. G., & Kaplan, D. L. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.05.002 · Cited by 8 · see citing works
Coffee and Alzheimer's disease
Mirzaei, F., Agbaria, L., Bhatnagar, K., Sirimanne, N., A'amar, N. O., Jindal, V., Thilagendra, A. G., & Raba, F. T. (2024) · Progress in brain research · doi:10.1016/bs.pbr.2024.06.002 · Cited by 7 · see citing works
Kim, E., Robinson, N. M., & Newman, B. M. (2021) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2021.07.009 · Cited by 7 · see citing works
Fu, X., Li, H., Chen, X., Cai, J., Yao, T., Song, L., Cen, M., & Wu, J. (2022) · Nutritional Neuroscience · doi:10.1080/1028415x.2022.2071809 · Cited by 6 · see citing works
Atanasova, M. (2025) · Pharmaceuticals · doi:10.3390/ph18101457 · Cited by 5 · see citing works
Association Between Caffeine Intake and Alzheimer’s Disease Progression: A Systematic Review
Ashfaq, Z., Younas, Z., Nathaniel, E., Rehman, A., Siddiqi, A., Rasool, N., & Amir, M. (2025) · Cureus · doi:10.7759/cureus.80923 · Cited by 5 · see citing works
Wang, Z. (2025) · American Journal of Cancer Research · doi:10.62347/vuzh4644 · Cited by 5 · see citing works
Shamsi, A., Shahwan, M. J., Gupta, D. D., Abdullah, K. M., & Khan, M. S. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03696-y · Cited by 5 · see citing works
Babylon, L., Meißner, J., & Eckert, G. P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210029 · Cited by 4 · see citing works
Natural molecules in neuroprotection and neurotoxicity in neurodegenerative diseases
Castillo, I. L. D., Vegas‐Gomez, L., Loureiro, J. A., & Moreno‐González, I. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23763-8.00001-4 · Cited by 3 · see citing works
Konsumsi Kopi untuk Mencegah Penyakit Alzheimer
Husodo, B. (2020) · JURNAL ILMIAH KESEHATAN SANDI HUSADA · doi:10.35816/jiskh.v12i2.439 · Cited by 3 · see citing works
Commercial and Instant Coffees Effectively Lower Aβ1-40 and Aβ1-42 in N2a/APPswe Cells
Zhang, L., Cao, J. A., Yang, H., Pham, P., Khan, U., Brown, B., Wang, Y., Zieneldien, T., & Cao, C. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.850523 · Cited by 3 · see citing works
Rivera-Manzorro, L., Aliaño–González, M. J., Barbero, G. F., Chinchilla, N., Macías, F. A., Lovillo, M. P., & Carrera, C. (2026) · Food & Function · doi:10.1039/d5fo05193b · Cited by 2 · see citing works
Boschetti, J. C. L., Soares, K. L., Carvalho, G. R., Filho, A. C. V., Ton, A. M. M., Pereira, T. D. M. C., & Scherer, R. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230843 · Cited by 2 · see citing works
Coffee and brain health: An introductory overview
Raza, M. L. (2024) · Progress in brain research · doi:10.1016/bs.pbr.2024.06.010 · Cited by 2 · see citing works
Liang, P., Yang, L., Chen, Y., Cheng, Z., Gao, Y., Sui, C., Zhang, X., Wang, N., Wang, Y., Liang, C., et al. (2025) · Brain and Behavior · doi:10.1002/brb3.70862 · Cited by 1 · see citing works
Babylon, L., Limbeck, M. T., & Eckert, G. P. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.20.537643 · Cited by 2 · see citing works
Psychoactive substances: novel molecular insights and therapeutic potential for Alzheimer's disease
Fu, C.-L., Li, X., Liu, X., Zheng, Y., Ma, X., Zhang, B., Chen, S. X., Hu, L., Su, S., Wang, X., et al. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00498-1 · Cited by 2 · see citing works
Anticholinesterase and Anticalaleptic Effects of Instant Coffee
Köhn, D., Molska, G. R., de Paula-Freire, L. I. G., Negri, G., Carlini, E. A., & Mendes, F. R. (2023) · Journal of Medicinal Food · doi:10.1089/jmf.2022.0148 · Cited by 1 · see citing works
Akasaki, Y., Shimokihara, S., Hidaka, Y., Maruta, M., Han, G., Kamasaki, T., Kumura, Y., Kukizaki, W., Nakahara, R., Makizako, H., et al. (2025) · Clinical Gerontologist · doi:10.1080/07317115.2025.2597956 · Cited by 1 · see citing works
Is caffeine a potential therapeutic intervention for Alzheimer's disease?
Zhai, Y., Yelanchezian, Y. M. M., & Kwakowsky, A. (2023) · Brain Network and Modulation · doi:10.4103/2773-2398.379339 · Cited by 2 · see citing works
Precision Nutrition in Aging and Brain Health
Chen, S. T., & Small, G. W. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15315-0.00017-1 · Cited by 1 · see citing works
Suganuma, T., Hatori, S., Chen, C., Hori, S., Kanuka, M., Liu, C.-Y., Tatsuzawa, C., Yanagisawa, M., & Hayashi, Y. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240033 · Cited by 1 · see citing works
Daily fluid intake and brain amyloid deposition: A cohort study
Kim, J. W., Byun, M. S., Yi, D., Jung, J. H., Kong, N., Chang, Y. Y., Jung, G., Ahn, H., Lee, J., Kang, K. M., et al. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251314176 · Cited by 1 · see citing works
Self-citationLi, C., Liang, X., Jia, Y., Wen, Y., Zhang, H., Cheng, S., Pan, C., Zhang, J., Zhang, Z., Chen, Y., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-910538/v1
Babylon, L., Meißner, J., & Eckert, G. P. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.24.538048
Roles of Purinergic Receptors in Alzheimer’s Disease
Delarasse, C., & Blum, D. L. (2023) · Springer eBooks · doi:10.1007/978-3-031-26945-5_8
Clinical and biochemical markers of neurodegenerative process in Alzheimer's disease
Жукова, Н. Г., Kolupaeva, E., Zhukova, I. A., Izhboldina, O., & Masenko, A. Y. (2023) · Vestnik nevrologii psihiatrii i nejrohirurgii (Bulletin of Neurology Psychiatry and Neurosurgery) · doi:10.33920/med-01-2308-08
Additional file 2 of Sex-specific DNA methylation differences in Alzheimer’s disease pathology
Zhang, L., Young, J. I., Gomez, L., Silva, T. C., Schmidt, M. A., Cai, J., Chen, X., Martin, E. R., & Wang, L. (2021) · Figshare · doi:10.6084/m9.figshare.14490464
Role of Nutrition in Maintaining Brain Health
Dehghani-Beshneh, M., Khatami, M., Ghiasinejad, S., & Sarasyabi, M. S. (2024) · Nutritional neurosciences · doi:10.1007/978-981-97-4117-5_6
Caffeine and potential use in Alzheimer’s disease
Büschgens, L., Janitschke, D., Lauer, A. A., Grimm, M. O. W., & Wirths, O. (2024) · Coffee in Health and Disease Prevention · doi:10.1016/b978-0-443-13868-3.00029-6
Coffee and Neurodegenerative Diseases
Godos, J., Castellano, S., Bonaccio, M., Zambrano-Villacres, R., Paladino, N., Bella, R., & Lanza, G. (2025) · Royal Society of Chemistry eBooks · doi:10.1039/9781839166853-00257
Additional file 1 of Sex-specific DNA methylation differences in Alzheimer’s disease pathology
Zhang, L., Young, J. I., Gomez, L., Silva, T. C., Schmidt, M. A., Cai, J., Chen, X., Martin, E. R., & Wang, L. (2021) · Figshare · doi:10.6084/m9.figshare.14490461
Li, P., Liu, Y., Liu, H., Chen, Y., Cheng, D., Zhao, Y., & Lv, Z. (2026) · Nutrición Hospitalaria · doi:10.20960/nh.06195
Jóźwicka, A., Janikowski, W., Bąkowska, E., Stępka, A., Jaworowicz, L., Plichtowicz-Kordowska, W., Lewandowska, K., Awad, S., Szymonek, P., & Zysk, A. (2026) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.2(50).2026.5914
- Authors
- Kim, J. W., Byun, M. S., Yi, D., Lee, J. H., Jeon, S. Y., Jung, G., Lee, H. N., Sohn, B. K., Lee, J.-Y., Kim, Y. K., Shin, S. A., Sohn, C.-H., Lee, D. Y., & for the KBASE Research Group
- Affiliations
- Hallym University (KR)
- Seoul National University (KR)
- Inje University (KR)
- Corresponding author
- Lee, Jun Ho
- Lee, Jun-Young
- Lee, Dong Young
- ORCID
- Venue
- Translational Psychiatry
- Published
- 2019-10-22
- Volume
- 9
- Issue
- 1
- Pages
- 270-270
- ISSN
- 2158-3188 (ISSN-L)
- PMC
- PMC6805864
- OpenAlex
- W2982030705
- Cited by
- 86
- References
- 49
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 12 · 2023: 22 · 2022: 12 · 2021: 20 · 2020: 5 · 2019: 1 · 2018: 1
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Translational Psychiatry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Ministry of Science, ICT and Future Planning (NRF-2014M3C7A1046042)
- Korea Health Industry Development Institute (HI18C0630, HI19C0149)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- coffee consumption, Alzheimer's disease, amyloid-beta deposition, Pittsburgh compound B, white matter hyperintensities, brain hypometabolism, brain atrophy, neurodegeneration, cognitive decline, older adults, neuroprotection
- MeSH terms
- Aged, Aging, Alzheimer Disease, Brain, Coffee, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Prospective Studies, Logistic Models, Amyloid beta-Peptides, Dietary Supplements, Positron-Emission Tomography, Cognitive Dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
