Cited by 41Antioxidant Activity and Oxidative StressNitric Oxide and Endothelin EffectsAtherosclerosis and Cardiovascular Diseases

Fucoxanthin Protects against oxLDL‐Induced Endothelial Damage via Activating the AMPK‐Akt‐CREB‐PGC1α Pathway

Ou, Hsiu‐Chung, Chou, Wan‐Ching, Chu, Pei‐Ming, Hsieh, Pei‐Ling, Hung, Ching‐Hsia, Tsai, Kun‐Ling·2019·Molecular Nutrition & Food Research

Abstract

SCOPE: Atherosclerotic cardiovascular disease is the most prevalent cause of mortality and morbidity. Fucoxanthin (FX) possesses anti-hypertensive and anti-obesity properties. However, the molecular mechanisms underlying the inhibitory effects of FX on oxidized low-density lipoprotein (oxLDL)-induced oxidative injuries in human endothelial cells are still largely unknown. This study aims to test the hypothesis that FX protects against oxLDL-induced oxidative stress by upregulating AMP-activated protein kinase (AMPK) and to explore the roles of cAMP response element binding protein (CREB) and peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α). METHODS AND RESULTS: Human umbilical vein endothelial cells are treated with oxLDL in the presence or absence of FX. FX significantly increases AMPK phosphorylation. In addition, FX diminishes oxLDL-mediated nicotinamide adenine dinucleotide phosphate oxidase activation by inhibiting protein kinase C and subsequently inducing reactive oxygen species generation and impairing the activity of the endogenous antioxidant enzyme superoxidase dismutase. Furthermore, FX restores oxLDL-mediated dephosphorylation of phosphoinositide-3-kinase/Akt and decreases CREB and PGC-1α expression to nearly normal levels. Moreover, FX ameliorates the oxLDL-mediated suppression of mitochondrial function and apoptosis. CONCLUSION: These findings provide new insights into the possible molecular mechanisms by which FX mitigates oxLDL-induced endothelial oxidative stress and mitochondrial dysfunction.

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Crossref · 10.1002/mnfr.201801353

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  • The protective effects of fucoxanthin were attributed to activation of the AMPK-protein kinase C-NOX signaling pathway.

    “The protective effects of fucoxanthin were attributed to activation of the AMPK-protein kinase C-NOX signaling pathway.”

    From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [129]

  • Fucoxanthin alleviated oxidative damage of endothelial cells treated by oxLDL.

    “Fucoxanthin, a natural marine carotenoid extracted from edible seaweeds, alleviated oxidative damage of ECs treated by oxLDL.”

    From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [129]

  • Suppression of oxidative stress blunted activation of the protein kinase B-cyclic AMP-responsive element binding protein-PGC1α pathway, which ameliorated mitochondrial dysfunction and apoptosis.

    “Moreover, the suppression of oxidative stress, in turn, blunted the activation of the protein kinase B-cyclic AMP-responsive element binding protein–PGC1α pathway, which ameliorated mitochondrial dysfunction and apoptosis [129].”

    From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [129]

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Authors
Ou, H., Chou, W., Chu, P., Hsieh, P., Hung, C., & Tsai, K.
Affiliations
  • Asia University (TW)
  • National Cheng Kung University (TW)
  • China Medical University (TW)
Corresponding author
  • Hung, Ching‐Hsia
  • Tsai, Kun‐Ling
Venue
Molecular Nutrition & Food Research
Publisher
Wiley
Published
2019-04-10
Volume
63
Issue
10
Pages
e1801353-e1801353
ISSN
  • 1613-4125 (ISSN-L)
  • 1613-4133
OpenAlex
W2923522051
Cited by
41
References
49
Citations by year
2026: 5 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 7 · 2020: 7 · 2019: 2
FWCI
3.15
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Nutrition & Food Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
China Medical University (CMU104‐N‐02)
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords
fucoxanthin, oxidized LDL, endothelial cells, AMPK, Akt, CREB, PGC-1α, oxidative stress, NADPH oxidase, protein kinase C, superoxide dismutase, mitochondrial dysfunction, apoptosis, atherosclerosis, carotenoids
MeSH terms
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Endothelium, Vascular, Humans, Lipoproteins, LDL, Phosphorylation, Cyclic AMP Response Element-Binding Protein, Reactive Oxygen Species, Oxidative Stress, NADPH Oxidases, Protective Agents, Xanthophylls, Proto-Oncogene Proteins c-akt, Membrane Potential, Mitochondrial, AMP-Activated Protein Kinases, Human Umbilical Vein Endothelial Cells

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