AMP-activated kinase may suppress NADPH oxidase activation in vascular tissues

McCarty, Mark F.; Barroso-Aranda, Jorge; Contreras, Francisco

doi:10.1016/j.mehy.2008.12.024

Cited by 22Nitric Oxide and Endothelin EffectsRedox biology and oxidative stressMetabolism, Diabetes, and Cancer

AMP-activated kinase may suppress NADPH oxidase activation in vascular tissues

McCarty, Mark F., Barroso-Aranda, Jorge, Contreras, Francisco·2009·Medical Hypotheses

DOI 10.1016/j.mehy.2008.12.024

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Abstract

Activation of AMP-activated kinase (AMPK) suppresses NF-kappaB-mediated transcription in endothelial cells exposed to palmitate or TNF-alpha; it also impedes angiotensin II-driven proliferation in vascular smooth muscle cells. These phenomena become predictable if we postulate that AMPK can inhibit activation of NADPH oxidase. Such an effect would make sense from a homeostatic perspective, and moreover there is direct evidence that AMPK suppresses NADPH oxidase activation in neutrophils. New evidence that sub-pathological levels of peroxynitrite can activate AMPK suggest that this enzyme may act as an "early warning signal" for oxidant stress; inhibiting NADPH oxidase would constitute a rational feedback response to such a signal.

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AMPK negatively regulates NOX by reducing its phosphorylation and preventing P47phox's translocation to membrane.
“Additional evidence supporting AMPK protection against oxidative stress is that AMPK negatively regulates NOX by reducing its phosphorylation and preventing P47phox’s translocation to membrane [70,151].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [151]

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Authors: McCarty, M. F., Barroso-Aranda, J., & Contreras, F.
Affiliations: Oasis of Hope Hospital (MX)
Corresponding author: McCarty, Mark F.
ORCID: McCarty, Mark F.
Contreras, Francisco
Venue: Medical Hypotheses
Publisher: Elsevier BV
Published: 2009-04
Volume: 72
Issue: 4
Pages: 468-470
ISSN: 0306-9877 (ISSN-L)
DOI: 10.1016/j.mehy.2008.12.024
OpenAlex: W1965694145
Cited by: 22
References: 60
Citations by year: 2021: 1 · 2020: 3 · 2019: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 5
FWCI: 2.22
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Medical Hypotheses (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: AMPK, NADPH oxidase, oxidative stress, peroxynitrite, NF-κB, endothelial cells, vascular smooth muscle cells, neutrophils, vascular homeostasis
MeSH terms: Endothelium, Vascular, Enzyme Activation, Homeostasis, Humans, Tumor Necrosis Factor-alpha, NF-kappa B, NADPH Oxidases, AMP-Activated Protein Kinases

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AMP-activated kinase may suppress NADPH oxidase activation in vascular tissues

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