The DOI matches its Crossref record; 46 of the 49 references it cites were found in a registry or an index.
Lactobacillus and Bifidobacterium Improves Physiological Function and Cognitive Ability in Aged Mice by the Regulation of Gut Microbiota
Abstract
SCOPE: Age-related degeneration is associated with imbalances of gut microbiota and its related immune system, thus gut microbiota dysbiosis is considered to be a key target to improve senescence. The potential roles of probiotics on physiological function and cognitive ability in aged mice are investigated in this study. METHODS AND RESULTS: Lactobacillus casei LC122 or Bifidobacterium longum BL986, are orally administrated for 12 weeks, and the anti-aging effects, as well as the composition and function of gut microbiota, are investigated in aged mice. Probiotics supplementation ameliorates hepatic lipid accumulation, enhances muscle strength and function, attenuates oxidative stress and inflammation in peripheral tissues, and improves gut barrier function. These results are associated with improved learning and memory ability as assessed by behavioral tests and upregulation of neurodegenerative and neurotrophic factors expressions in hippocampus. Moreover, the diversity and composition of gut microbiota are altered in aged mice, and both probiotics treatment display distinguished features of gut microbiota. Comparisons of two probiotic strains reveal significant differences in the taxa at family and genus level, leading to the functional profile change of the microbial community. CONCLUSION: L. casei LC122 and B. longum BL986 might be used as novel and promising anti-aging agents in human.
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“Animal studies have demonstrated that administration of probiotics (e.g., Lactobacillus plantarum, L. rhamnosus, B. longum) can have anxiolytic and antidepressive effects (222, 223) and can impact aspects of cognitive function (224).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [224]
In the citing paper
“Oral administration of Lactobacillus casei LC122 and Bifidobacterium ongum BL986 for 12 weeks enhances muscle strength and function in C57BL/6 mice [161].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [161]
Citations
Cites
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Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice
Ma, L., Ni, Y., Wang, Z., Tu, W., Ni, L., Zhuge, F., Zheng, A., Hu, L., Zhao, Y., Zheng, L., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1832857 · Cited by 608
Self-citationDiet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451
Montero, C. G., Fraile‐Μartinez, O., Gomez-Lahoz, A. M., Pekarek, L., Castellanos, A. J., Noguerales-Fraguas, F., Coca, S., Guijarro, L. G., García‐Honduvilla, N., Asúnsolo, Á., et al. (2021) · Nutrients · doi:10.3390/nu13020699 · Cited by 487
Understanding the gut microbiota and sarcopenia: a systematic review
Liu, C., Cheung, W., Li, J., Chow, S. K., Yu, J., Wong, S. H., Ip, M., Sung, J. J. Y., & Wong, R. M. Y. (2021) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12784 · Cited by 363
Ling, Z., Liu, X., Cheng, Y., Yan, X., & Wu, S. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1867054 · Cited by 378
Metadata
- Authors
- Ni, Y., Yang, X., Zheng, L., Wang, Z., Wu, L., Jiang, J., Yang, T., Ma, L., & Fu, Z.
- Affiliations
- Zhejiang University of Technology (CN)
- Corresponding author
- Fu, Zhengwei
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2019-09-25
- Volume
- 63
- Issue
- 22
- Pages
- e1900603-e1900603
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- OpenAlex
- W2969326780
- Cited by
- 255
- References
- 49
- Citations by year
- 2026: 18 · 2025: 38 · 2024: 51 · 2023: 47 · 2022: 45 · 2021: 35 · 2020: 19 · 2019: 2
- FWCI
- 19.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Nutrition & Food Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- probiotics, Lactobacillus casei, Bifidobacterium longum, gut microbiota, aging, cognitive function, learning and memory, hepatic lipid accumulation, muscle strength, oxidative stress, inflammation, intestinal barrier, hippocampus, neurotrophic factors, aged mice
- MeSH terms
- Gastrointestinal Microbiome, Bifidobacterium longum, Aging, Animals, Cognition, Lacticaseibacillus casei, Learning, Male, Memory, Mice, Inbred C57BL, Probiotics, Mice, Microbiota
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