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Garlic‐Derived Organosulfur Compounds Regulate Metabolic and Immune Pathways in Macrophages and Attenuate Intestinal Inflammation in Mice
Open accessPublished version of a preprint
Abstract
Scope : Garlic is a source of bioactive phytonutrients that may have anti‐inflammatory or immunomodulatory properties. The mechanism(s) underlying the bioactivity of these compounds and their ability to regulate responses to enteric infections remains unclear. Methods and Results : This study investigates if a garlic‐derived preparation (PTSO‐PTS) containing two organosulfur metabolites, propyl‐propane thiosulfonate (PTSO), and propyl‐propane thiosulfinate (PTS), regulate inflammatory responses in murine macrophages and intestinal epithelial cells (IEC) in vitro, as well as in a model of enteric parasite‐induced inflammation. PTSO‐PTS decreases lipopolysaccharide‐induced secretion of TNFα, IL‐6, and IL‐27 in macrophages. RNA‐sequencing demonstrates that PTSO‐PTS strongly suppresses pathways related to immune and inflammatory signaling. PTSO‐PTS induces the expression of a number of genes involved in antioxidant responses in IEC during exposure to antigens from the parasite Trichuris muris . In vivo, PTSO‐PTS does not affect T. muris establishment or intestinal T‐cell responses but significantly alters cecal transcriptomic responses. Notably, a reduction in T. muris ‐induced expression of Tnf , Saa2 , and Nos2 is observed. Conclusion : Garlic‐derived organosulfur compounds exert anti‐inflammatory effects in macrophages and IEC, and regulate gene expression during intestinal infection. These compounds and related organic molecules may thus hold potential as functional food components to improve gut health in humans and animals.
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Metadata
- Authors
- Zhu, L., Myhill, L. J., Andersen‐Civil, A. I. S., Thamsborg, S. M., Blanchard, A., & Williams, A. R.
- Affiliations
- University of Copenhagen (DK)
- Pancosma ADM A one business center Rolle CH‐1180 Switzerland
- Corresponding author
- Williams, Andrew R.
- ORCID
- Venue
- Molecular Nutrition & Food Research
- Publisher
- Wiley
- Published
- 2022-03-07
- Volume
- 66
- Issue
- 7
- Pages
- e2101004-e2101004
- ISSN
- 1613-4125 (ISSN-L)
- 1613-4133
- PMC
- PMC9286605
- OpenAlex
- W4210261785
- Cited by
- 23
- References
- 1
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 4 · 2023: 6 · 2022: 4
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Molecular Nutrition & Food Research (publishedVersion, cc-by-nc-nd)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by-nc-nd)
- Funders
- Novo Nordisk Fonden (0052422)
- Det Frie Forskningsråd (7026‐0094B)
- China Scholarship Council (201806910065)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- garlic, organosulfur compounds, macrophages, intestinal inflammation, Trichuris muris, intestinal parasites, anti-inflammatory activity, immune signaling, antioxidant response, intestinal epithelial cells, functional foods, gut health, TNF-α, interleukin-6, IL-27, nitric oxide
- MeSH terms
- Animals, Anti-Inflammatory Agents, Antioxidants, Garlic, Inflammation, Macrophages, Mice
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