c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649 · see citing works

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

Deng, C., Zhang, P., Wade Harper, J., Elledge, S. J., & Leder, P. (1995) · Cell · doi:10.1016/0092-8674(95)90039-x · Cited by 2,113 · see citing works

Inducible Gene Targeting in Mice

Kühn, R., Schwenk, F., Aguet, M., & Rajewsky, K. (1995) · Science · doi:10.1126/science.7660125 · Cited by 1,915 · see citing works

Liver regeneration: from myth to mechanism

Taub, R. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1489 · Cited by 1,567 · see citing works

Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice

Cressman, D. E., Greenbaum, L. E., DeAngelis, R. A., Ciliberto, G., Furth, E. E., Poli, V., & Taub, R. (1996) · Science · doi:10.1126/science.274.5291.1379 · Cited by 1,536 · see citing works

Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type I tumor necrosis factor receptor

Yamada, Y., Kirillova, I., Peschon, J. J., & Fausto, N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1441 · Cited by 944 · see citing works

Hepatocyte growth factor/ <i>c-met</i> signaling pathway is required for efficient liver regeneration and repair

Huh, C.-G., Factor, V. M., Sánchez, A., Uchida, K., Conner, E. A., & Thorgeirsson, S. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306068101 · Cited by 750 · see citing works

Liver regeneration and repair: Hepatocytes, progenitor cells, and stem cells

Fausto, N. (2004) · Hepatology · doi:10.1002/hep.20214 · Cited by 720 · see citing works

Phosphorylation of human p53 by p38 kinase coordinates N‐terminal phosphorylation and apoptosis in response to UV radiation

Bulavin, D. V., Saito, S., Hollander, M. C., Sakaguchi, K., Anderson, C. W., Appella, E., & Fornace, A. J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.23.6845 · Cited by 704 · see citing works

p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytesPreprint

Engel, F. B., Schebesta, M., Duong, M. T., Lü, G., Ren, S. V., Madwed, J. B., Jiang, H., Wang, Y., & Keating, M. T. (2005) · Genes & Development · doi:10.1101/gad.1306705 · Cited by 595 · see citing works

Control of cell cycle progression by c-Jun is p53 dependentPreprint

Schreiber, M., Kolbus, A., Piu, F., Szabowski, A., Möhle-Steinlein, U., Tian, J., Karin, M., Angel, P., & Wagner, E. F. (1999) · Genes & Development · doi:10.1101/gad.13.5.607 · Cited by 576 · see citing works

c-Jun is essential for normal mouse development and hepatogenesis

Hilberg, F., Aguzzi, A., Howells, N., & Wagner, E. F. (1993) · Nature · doi:10.1038/365179a0 · Cited by 539 · see citing works

Transforming growth factor alpha may be a physiological regulator of liver regeneration by means of an autocrine mechanism.

Mead, J. E., & Fausto, N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.5.1558 · Cited by 535 · see citing works

Met provides essential signals for liver regeneration

Borowiak, M., Garratt, A. N., Wüstefeld, T., Strehle, M., Trautwein, C., & Birchmeier, C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403412101 · Cited by 497 · see citing works

Liver Tumor Development

Eferl, R., Ricci, R., Kenner, L., Zenz, R., David, J., Rath, M., & Wagner, E. F. (2003) · Cell · doi:10.1016/s0092-8674(03)00042-4 · Cited by 471 · see citing works

AKT/PKB Phosphorylation of p21Cip/WAF1 Enhances Protein Stability of p21Cip/WAF1 and Promotes Cell Survival

Li, Y., Dowbenko, D. J., & Lasky, L. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109062200 · Cited by 442 · see citing works

p53‐inducible Wip1 phosphatase mediates a negative feedback regulation of p38 MAPK‐p53 signaling in response to UV radiation

Takekawa, M., Adachi, M., Nakahata, A., Nakayama, I., Itoh, F., Tsukuda, H., Taya, Y., & Imai, K. (2000) · The EMBO Journal · doi:10.1093/emboj/19.23.6517 · Cited by 419 · see citing works

Antibodies to tumor necrosis factor-alpha inhibit liver regeneration after partial hepatectomy

Akerman, P., Cote, P., Yang, S. Q., McClain, C., Nelson, S., Bagby, G. J., & Diehl, A. M. (1992) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1992.263.4.g579 · Cited by 401 · see citing works

A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture.Preprint

Johnson, R. S., van Lingen, B., Papaioannou, V. E., & Spiegelman, B. M. (1993) · Genes & Development · doi:10.1101/gad.7.7b.1309 · Cited by 387 · see citing works

Rapid activation of the stat3 transcription complex in liver regeneration

Cressman, D. E., Diamond, R. H., & Taub, R. (1995) · Hepatology · doi:10.1002/hep.1840210531 · Cited by 314 · see citing works

The Mammalian UV Response

Shaulian, E., Schreiber, M., Piu, F., Beeche, M., Wagner, E. F., & Karin, M. (2000) · Cell · doi:10.1016/s0092-8674(00)00193-8 · Cited by 295 · see citing works

Functions of c-Jun in Liver and Heart Development

Eferl, R., Sibilia, M. C., Hilberg, F., Fuchsbichler, A., Kufferath, I., Guertl, B., Zenz, R., Wagner, E. F., & Zatloukal, K. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.5.1049 · Cited by 276 · see citing works

p38 Kinase Mediates UV-induced Phosphorylation of p53 Protein at Serine 389

Huang, C., Ma, W.-Y., Maxiner, A., Sun, Y., & Dong, Z. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.18.12229 · Cited by 274 · see citing works

Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c‐jun in the liver

Behrens, A., Sibilia, M. C., David, J., Möhle-Steinlein, U., Tronche, F., Schütz, G., & Wagner, E. F. (2002) · The EMBO Journal · doi:10.1093/emboj/21.7.1782 · Cited by 270 · see citing works

CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy.

Greenbaum, L. E., Li, W., Cressman, D. E., Peng, Y., Ciliberto, G., Poli, V, & Taub, R. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3135 · Cited by 270 · see citing works

MDM2 Is a Negative Regulator of p21 , Independent of p53

Zhang, Z., Wang, H., Li, M., Agrawal, S., Chen, X., & Zhang, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312264200 · Cited by 253 · see citing works

CCAAT/Enhancer Binding Protein α Regulates p21 Protein and Hepatocyte Proliferation in Newborn Mice

Timchenko, N. A., Harris, T. E., Wilde, M. D., Bilyeu, T. A., Burgess-Beusse, B. L., Finegold, M. J., & Darlington, G. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.12.7353 · Cited by 239 · see citing works

Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration.

Wu, H., Wade, M., Krall, L., Grisham, J., Xiong, Y., & Van Dyke, T. (1996) · Genes &amp; Development · doi:10.1101/gad.10.3.245 · Cited by 234 · see citing works

The Stress-activated Protein Kinases p38α and JNK1 Stabilize p21Cip1 by Phosphorylation

Kim, G.-Y., Mercer, S. E., Ewton, D. Z., Yan, Z., Jin, K., & Friedman, E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201299200 · Cited by 231 · see citing works

Rapid DNA binding by nuclear factor kappa B in hepatocytes at the start of liver regeneration.

Fitzgerald, M. J., Webber, E. M., Donovan, J. R., & Fausto, N. (1995) · PubMed · Cited by 213 · see citing works

Involvement of p21 and p27 in the regulation of CDK activity and cell cycle progression in the regenerating liver

Albrecht, J. H., Poon, R. Y. C., Ahonen, C. L., Rieland, B. M., Deng, C., & Crary, G. S. (1998) · Oncogene · doi:10.1038/sj.onc.1201728 · Cited by 198 · see citing works

JunB can substitute for Jun in mouse development and cell proliferation

Passegué, E., Jochum, W., Behrens, A., Ricci, R., & Wagner, E. F. (2002) · Nature Genetics · doi:10.1038/ng790 · Cited by 162 · see citing works

Heparin-binding Epidermal Growth Factor-like Growth Factor Links Hepatocyte Priming with Cell Cycle Progression during Liver Regeneration

Mitchell, C., Nivison, M. P., Jackson, L. F., Fox, R., Lee, D. C., Campbell, J. S., & Fausto, N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m412372200 · Cited by 160 · see citing works

Regulation of p21WAF1/CIP1 Stability by WISp39, a Hsp90 Binding TPR Protein

Jascur, T., Brickner, H., Salles-Passador, I., Barbier, V., El Khissiin, A., Smith, B., Fotedar, R., & Fotedar, A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2004.11.049 · Cited by 145 · see citing works

Regulation of Cyclin–Dependent Kinase Inhibitor P21Waf1/Cip1/Sdi1 Gene Expression in Hepatic Regeneration

Albrecht, J. H., Meyer, A., & Hu, M. Y. (1997) · Hepatology · doi:10.1002/hep.510250311 · Cited by 116 · see citing works

Clostridium difficile Toxin A–Induced Colonocyte Apoptosis Involves p53-Dependent p21(WAF1/CIP1) Induction via p38 Mitogen-Activated Protein Kinase

Kim, H., Kokkotou, E. G., Na, X., Rhee, S. H., Moyer, M. P., Pothoulakis, C., & LaMont, J. T. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.09.011 · Cited by 96 · see citing works

Activation of p38 MAP kinase by DNA double‐strand breaks in V(D)J recombination induces a G2/M cell cycle checkpoint

Pedraza‐Alva, G., Koulnis, M., Charland, C., Thornton, T. M., Clements, J. L., Schlissel, M. S., & Rincón, M. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7600972 · Cited by 66 · see citing works

IFI16 as a Negative Regulator in the Regulation of p53 and p21Waf1

Kwak, J. C., Ongusaha, P. P., Ouchi, T., & Lee, S. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308012200 · Cited by 56 · see citing works

Liver regeneration

Diehl, A. M. (2002) · Frontiers in bioscience · doi:10.2741/a925 · Cited by 55 · see citing works

High-Intensity p38 Kinase Activity Is Critical for p21 cip1 Induction and the Antiproliferative Function of G i Protein-Coupled Receptors

Alderton, F., Humphrey, P. P. A., & Sellers, L. A. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.5.1119 · Cited by 48 · see citing works

Prolonged Jun N-terminal kinase (JNK) activation and the upregulation of p53 and p21WAF1/CIP1 preceded apoptosis in hepatocytes after partial hepatectomy and cisplatin

Kobayashi, K., & Tsukamoto, I. (2001) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(01)00059-x · Cited by 35 · see citing works

Specific activation of AP‐1 but not Stat3 in regenerating liver in mice

Heim, M. H., Gamboni, G., Beglinger, C., & Gyr, K. (1997) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1997.2100770.x · Cited by 34 · see citing works

Clostridium difficile toxin

Chang, T.-W., Bartlett, J. G., & Taylor, N. S. (1981) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(81)90025-5 · Cited by 28 · see citing works

Rapid activation of the Stat3 transcription complex in liver regeneration

Cressman, D. E. (1995) · Hepatology · doi:10.1016/0270-9139(95)90068-3 · Cited by 24 · see citing works

Signal integration by JNK and p38 MAPK pathways in cancer development

Wagner, E. F., & Nebreda, Á. R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2694 · Cited by 2,583 · see citing works

Reparative inflammation takes charge of tissue regeneration

Karin, M., & Clevers, H. (2016) · Nature · doi:10.1038/nature17039 · Cited by 767 · see citing works

Mitogen-Activated Protein (MAP) Kinase/MAP Kinase Phosphatase Regulation: Roles in Cell Growth, Death, and Cancer

Boutros, T., Chevet, É., & Metrakos, P. P. (2008) · Pharmacological Reviews · doi:10.1124/pr.107.00106 · Cited by 545 · see citing works

A Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches

Seki, E., Brenner, D. A., & Karin, M. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.004 · Cited by 488 · see citing works

JNK at the crossroad of obesity, insulin resistance, and cell stress response

Solinas, G., & Becattini, B. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.12.001 · Cited by 431 · see citing works

p38α suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway

Hui, L., Bakiri, L., Mairhorfer, A., Schweifer, N., Haslinger, C., Kenner, L., Komnenovic, V., Scheuch, H., Beug, H., & Wagner, E. F. (2007) · Nature Genetics · doi:10.1038/ng2033 · Cited by 353 · see citing works

Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin disease

Zenz, R., Eferl, R., Scheinecker, C., Redlich, K., Smolen, J. S., Schönthaler, H. B., Kenner, L., Tschachler, E., & Wagner, E. F. (2007) · Arthritis Research & Therapy · doi:10.1186/ar2338 · Cited by 353 · see citing works

Emerging roles of ATF2 and the dynamic AP1 network in cancer

Lopez‐Bergami, P., Lau, E. K., & Ronai, Z. A. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2681 · Cited by 346 · see citing works

The EGF receptor is required for efficient liver regeneration

Natarajan, A., Wagner, B., & Sibilia, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704126104 · Cited by 320 · see citing works

Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation

Hui, L., Zatloukal, K., Scheuch, H., Stępniak-Konieczna, E., & Wagner, E. F. (2008) · Journal of Clinical Investigation · doi:10.1172/jci37156 · Cited by 308 · see citing works

p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling

Yosef, R., Pilpel, N., Papismadov, N., Gal, H., Ovadya, Y., Vadai, E., Miller, S., Porat, Z., Ben‐Dor, S., & Krizhanovsky, V. (2017) · The EMBO Journal · doi:10.15252/embj.201695553 · Cited by 293 · see citing works

Impaired liver regeneration in Nrf2 knockout mice: role of ROS‐mediated insulin/IGF‐1 resistance

Beyer, T. A., Xu, W., Teupser, D., Keller, U. A. D., Bugnon, P., Hildt, E., Thiery, J., Kan, Y. W., & Werner, S. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601950 · Cited by 267 · see citing works

Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation

Procopio, M.-G., Laszlo, C., Al Labban, D., Kim, D. E., Bordignon, P., Jo, S.-H., Goruppi, S., Menietti, E., Ostano, P., Ala, U., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3228 · Cited by 223 · see citing works

Lack of p21 expression links cell cycle control and appendage regeneration in mice

Bedelbaeva, K., Snyder, A., Gourevitch, D., Clark, L., Zhang, X.-M., Leferovich, J., Cheverud, J. M., Lieberman, P., & Heber-Katz, E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000830107 · Cited by 207 · see citing works

The role of JNK in the development of hepatocellular carcinomaPreprint

Das, M., Garlick, D. S., Greiner, D. L., & Davis, R. J. (2011) · Genes & Development · doi:10.1101/gad.1989311 · Cited by 187 · see citing works

p38α: A Suppressor of Cell Proliferation and Tumorigenesis

Hui, L., Bakiri, L., Stępniak-Konieczna, E., & Wagner, E. F. (2007) · Cell Cycle · doi:10.4161/cc.6.20.4774 · Cited by 184 · see citing works

Mitogen-activated protein kinases in hepatocellular carcinoma development

Min, L., He, B., & Hui, L. (2010) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.10.011 · Cited by 176 · see citing works

Crosstalk and Signaling Switches in Mitogen-Activated Protein Kinase Cascades

Fey, D., Croucher, D. R., Kölch, W., & Kholodenko, B. Ν. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00355 · Cited by 169 · see citing works

Computational Identification of a p38SAPK-Regulated Transcription Factor Network Required for Tumor Cell Quiescence

Adam, A. P., George, A. D., Schewe, D. M., Bragado, P., Iglesias, B. V., Ranganathan, A. C., Kourtidis, A., Conklin, D. S., & Aguirre‐Ghiso, J. A. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3820 · Cited by 168 · see citing works

AP-1 Contributes to Chromatin Accessibility to Promote Sarcomere Disassembly and Cardiomyocyte Protrusion During Zebrafish Heart Regeneration

Beisaw, A., Kuenne, C. T., Günther, S., Dallmann, J., Wu, C. C., Bentsen, M. S., Looso, M., & Stainier, D. Y. R. (2020) · Circulation Research · doi:10.1161/circresaha.119.316167 · Cited by 160 · see citing works

Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3

Riehle, K. J., Campbell, J. S., McMahan, R. S., Johnson, M. M., Beyer, R. P., Bammler, T. K., & Fausto, N. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20070820 · Cited by 161 · see citing works

Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling

Batlle, R., Andrés, E., Gonzalez, L., Llonch, E., Igea, A., Gutierrez-Prat, N., Berenguer-Llergo, A., & Nebreda, A. R. (2019) · Nature Communications · doi:10.1038/s41467-019-10946-y · Cited by 142 · see citing works

Progenitor‐derived hepatocellular carcinoma model in the rat†

Andersen, J. B., Loi, R., Perra, A., Factor, V. M., Ledda‐Columbano, G. M., Columbano, A., & Thorgeirsson, S. S. (2009) · Hepatology · doi:10.1002/hep.23488 · Cited by 138 · see citing works

Gene Profiling in the Livers of Wild-type and PPARα-Null Mice Exposed to Perfluorooctanoic Acid

Rosen, M. B., Abbott, B. D., Wolf, D. C., Corton, J. C., Wood, C. R., Schmid, J. E., Das, K. P., ZEHR, R. D. J., Blair, E. T., & Lau, C. S. (2008) · Toxicologic Pathology · doi:10.1177/0192623308318208 · Cited by 132 · see citing works

Oncofetal HLF transactivates c-Jun to promote hepatocellular carcinoma development and sorafenib resistance

Xiang, D., Sun, W. C., Zhou, T., Zhang, C., Cheng, Z., Li, S., Jiang, W., Wang, R., Fu, G., Cui, X., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-317440 · Cited by 136 · see citing works

Altered hepatic triglyceride content after partial hepatectomy without impaired liver regeneration in multiple murine genetic models†

Newberry, E. P., Kennedy, S., Xie, Y., Luo, J., Stanley, S. E., Semenkovich, C. F., Crooke, R. M., Graham, M. J., & Davidson, N. O. (2008) · Hepatology · doi:10.1002/hep.22473 · Cited by 120 · see citing works

Curcumin-cyclodextrin complexes enhanced the anti-cancer effects of curcumin

Zhang, L., Man, S., Qiu, H., Liu, Z., Zhang, M., Ma, L., & Gao, W. (2016) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2016.09.021 · Cited by 115 · see citing works

p53 on the crossroad between regeneration and cancer

Charni‐Natan, M., Aloni-Grinstein, R., Molchadsky, A., & Rotter, V. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.117 · Cited by 112 · see citing works

Platelets in liver disease, cancer and regeneration

Kurokawa, T., & Ohkohchi, N. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i18.3228 · Cited by 111 · see citing works

The senotherapeutic drug ABT-737 disrupts aberrant p21 expression to restore liver regeneration in adult mice

Ritschka, B., Knauer-Meyer, T., Gonçalves, D. S., Mas, A., Plassat, J.-L., Durik, M., Jacobs, H., Pedone, E., Di Vicino, U., Cosma, M. P., et al. (2020) · Genes &amp; Development · doi:10.1101/gad.332643.119 · Cited by 105 · see citing works

Cellular plasticity balances the metabolic and proliferation dynamics of a regenerating liver

Chembazhi, U. V., Bangru, S., Hernaez, M., & Kalsotra, A. (2021) · Genome Research · doi:10.1101/gr.267013.120 · Cited by 102 · see citing works

Fibroblast growth factor 15 deficiency impairs liver regeneration in mice.

Kong, B., Huang, J., Zhu, Y., Li, G., Williams, J. A., Shen, S., Aleksunes, L., Richardson, J., Apte, U., Rudnick, D. A., et al. (2014) · American Journal of Physiology - Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00337.2013 · Cited by 107 · see citing works

Annexin A2 contributes to cisplatin resistance by activation of JNK-p53 pathway in non-small cell lung cancer cells

Feng, X., Liu, H., Zhang, Z., Gu, Y., Qiu, H., & He, Z. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0594-1 · Cited by 99 · see citing works

Gadd45β promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling

Papa, S., Zazzeroni, F., Fu, Y., Bubici, C., Alvarez, K., Dean, K., Christiansen, P. A., Anders, R. A., & Franzoso, G. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33913 · Cited by 92 · see citing works

Identification of microRNAs during rat liver regeneration after partial hepatectomy and modulation by ursodeoxycholic acid

Castro, R. E., Ferreira, D. M. S., Zhang, X., Borralho, P. M., Sarver, A. L., Zeng, Y., Steer, C. J., Kren, B. T., & Rodrigues, C. M. P. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00216.2010 · Cited by 91 · see citing works

Molecular Mechanisms of Liver Injury and Hepatocarcinogenesis: Focusing on the Role of Stress-Activated MAPK

Nakagawa, H., & Maeda, S. (2012) · Pathology Research International · doi:10.1155/2012/172894 · Cited by 90 · see citing works

Mitogen‐inducible gene‐6 is a negative regulator of epidermal growth factor receptor signaling in hepatocytes and human hepatocellular carcinoma†

Reschke, M., Ferby, I., Stępniak-Konieczna, E., Seitzer, N., Horst, D. A., Wagner, E. F., & Ullrich, A. (2009) · Hepatology · doi:10.1002/hep.23428 · Cited by 85 · see citing works

Interactions between Myc and Mediators of Inflammation in Chronic Liver Diseases

Liu, T., Zhou, Y., Ko, K. S., & Yang, H. (2015) · Mediators of Inflammation · doi:10.1155/2015/276850 · Cited by 84 · see citing works

Schistosoma mansoni Egg–Secreted Antigens Activate Hepatocellular Carcinoma–Associated Transcription Factors c‐Jun and STAT3 in Hamster and Human Hepatocytes

Roderfeld, M., Padem, S., Lichtenberger, J., Quack, T., Weiskirchen, R., Longerich, T., Schramm, G., Churin, Y., Irungbam, K., Tschuschner, A., et al. (2018) · Hepatology · doi:10.1002/hep.30192 · Cited by 76 · see citing works

Jun and JunD-dependent functions in cell proliferation and stress response

Meixner, A., Karreth, F. A., Kenner, L., Penninger, J. M., & Wagner, E. F. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.22 · Cited by 75 · see citing works

The Transcription Factor c-Jun Protects Against Sustained Hepatic Endoplasmic Reticulum Stress Thereby Promoting Hepatocyte Survival

Fuest, M., Willim, K., MacNelly, S., Fellner, N., Resch, G. P., Blum, H. E., & Hasselblatt, P. (2011) · Hepatology · doi:10.1002/hep.24699 · Cited by 75 · see citing works

Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase

Hasselblatt, P., Rath, M., Komnenovic, V., Zatloukal, K., & Wagner, E. F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706272104 · Cited by 75 · see citing works

Annexin A2 Silencing Induces G2 Arrest of Non-small Cell Lung Cancer Cells through p53-dependent and -independent Mechanisms

Wang, C., Chen, C.-L., Tseng, Y.-L., Fang, Y.-T., Lin, Y.-S., Su, W., Chen, C., Chang, K.-C., Wang, Y., & Lin, C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.351957 · Cited by 73 · see citing works

Regulation of cell signaling pathways by dietary agents for cancer prevention and treatment

Pandey, M. K., Gupta, S. C., Nabavizadeh, A., & Aggarwal, B. B. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.07.002 · Cited by 72 · see citing works

Antagonistic effects of selenium and lipid peroxides on growth control in early hepatocellular carcinoma

Rohr‐Udilova, N., Sieghart, W., Eferl, R., Stoiber, D., Björkhem‐Bergman, L., Eriksson, L. C., Stolze, K., Hayden, H., Keppler, B. K., Sagmeister, S., et al. (2011) · Hepatology · doi:10.1002/hep.24808 · Cited by 68 · see citing works

Critical role of c-Jun overexpression in liver metastasis of human breast cancer xenograft model

Zhang, Y., Pu, X., Shi, M., Chen, L., Song, Y., Lu, Q., Yuan, G., Zhang, H., Yu, M., Hu, M., et al. (2007) · BMC Cancer · doi:10.1186/1471-2407-7-145 · Cited by 68 · see citing works

The transcription factor c-JUN/AP-1 promotes HBV-related liver tumorigenesis in mice

Trierweiler, C., Hockenjos, B., Zatloukal, K., Thimme, R., Blum, H. E., Wagner, E. F., & Hasselblatt, P. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.121 · Cited by 67 · see citing works

Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17

Guinea‐Viniegra, J., Zenz, R., Scheuch, H., Jiménez, M., Bakiri, L., Petzelbauer, P., & Wagner, E. F. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63103 · Cited by 64 · see citing works

Deficiency of Histone Methyltransferase SET Domain‐Containing 2 in Liver Leads to Abnormal Lipid Metabolism and HCC

Li, X., Li, Q., Ju, L., Zhao, C. N., Zhao, L., Du, J., Wang, Y., Zheng, L., Song, B., Li, L., et al. (2020) · Hepatology · doi:10.1002/hep.31594 · Cited by 63 · see citing works

p53 as a Dichotomous Regulator of Liver Disease: The Dose Makes the Medicine

Krstić, J., Galhuber, M., Schulz, T. J., Schupp, M., & Prokesch, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030921 · Cited by 63 · see citing works

Molecular pathways of liver regeneration: A comprehensive review

Kiseleva, Y. V., Antonyan, S. Z., Zharikova, T. S., Tupikin, K. A., Kalinin, D. V., & Zharikov, Y. O. (2021) · World Journal of Hepatology · doi:10.4254/wjh.v13.i3.270 · Cited by 62 · see citing works

Hepatic apoptosis can modulate liver fibrosis through TIMP1 pathway

Wang, K., Lin, B., Brems, J. J., & Gamelli, R. L. (2013) · APOPTOSIS · doi:10.1007/s10495-013-0827-5 · Cited by 61 · see citing works

MoS 2 Nanozyme–Chlorella Hydrogels: Pioneering a Hepatocellular Carcinoma Integrative Therapy

Zhang, M., Zhou, J., Jiang, X., Shi, T., Jin, X., Ren, Y., Ji, K., Xin, Z., Zhang, Z., Yin, C., et al. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202417125 · Cited by 59 · see citing works

MLK3 Is Part of a Feedback Mechanism That Regulates Different Cellular Responses to Reactive Oxygen Species

Lee, H.-S., Hwang, C. Y., Shin, S., Kwon, K., & Cho, K. (2014) · Science Signaling · doi:10.1126/scisignal.2005260 · Cited by 59 · see citing works

Cascades of transcription regulation during liver regeneration

Kurinna, S. M., & Barton, M. C. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.03.013 · Cited by 55 · see citing works

Inactivation of p38 MAPK during liver regeneration

Campbell, J. S., Argast, G. M., Yuen, S. Y., Hayes, B. J., & Fausto, N. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.08.002 · Cited by 55 · see citing works

Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation

Hefetz-Sela, S., Stein, I., Klieger, Y., Porat, R. M., Sade-Feldman, M., Zreik, F., Nagler, A., Pappo, O., Quagliata, L., Dazert, E., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409700111 · Cited by 54 · see citing works

The matricellular protein CCN1 suppresses hepatocarcinogenesis by inhibiting compensatory proliferation

Chen, C.-C., Kim, K.-H., & Lau, L. F. (2015) · Oncogene · doi:10.1038/onc.2015.190 · Cited by 51 · see citing works

Human Liver Regeneration Is Characterized by the Coordinated Expression of Distinct MicroRNA Governing Cell Cycle Fate

Salehi, S., Brereton, H., Arno, M. J., Darling, D., Quaglia, A., O’Grady, J., Heaton, N. D., & Aluvihare, V. R. (2013) · American Journal of Transplantation · doi:10.1111/ajt.12183 · Cited by 50 · see citing works

Apoptosis Signaling Kinases: From Stress Response to Health Outcomes

Takeda, K., Naguro, I., Nishitoh, H., Matsuzawa, A., & Ichijo, H. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3392 · Cited by 48 · see citing works

Targeted Disruption of Mapk14 (p38MAPKα) in Granulosa Cells and Cumulus Cells Causes Cell-Specific Changes in Gene Expression Profiles that Rescue COC Expansion and Maintain Fertility

Liu, Z., Fan, H., Wang, Y., & Richards, J. S. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0086 · Cited by 50 · see citing works

Mark4 promotes adipogenesis and triggers apoptosis in 3T3‐L1 adipocytes by activating JNK1 and inhibiting p38MAPK pathways

Feng, M., Liang, T., Gan, L., Liu, Z., & Sun, C. (2014) · Biology of the Cell · doi:10.1111/boc.201400004 · Cited by 49 · see citing works

Proliferation-inhibiting pathways in liver regeneration

Liu, M., & Chen, P. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6613 · Cited by 49 · see citing works

Decoy oligodeoxynucleotide targeting activator protein-1 (AP-1) attenuates intestinal inflammation in murine experimental colitis

Moriyama, I., Ishihara, S., Rumi, M. A. K., Aziz, M., Mishima, Y., Oshima, N., Kadota, C., Kadowaki, Y., Amano, Y., & Kinoshita, Y. (2008) · Laboratory Investigation · doi:10.1038/labinvest.2008.38 · Cited by 48 · see citing works

Aloin Attenuates Oxidative Stress, Inflammation, and CCl 4 -Induced Liver Fibrosis in Mice: Possible Role of TGF-β/Smad Signaling

Bai, J., Qian, B., Cai, T., Chen, Y., Li, T., Cheng, Y., Wu, Z., Liu, C., Ye, M., Du, Y., et al. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c01721 · Cited by 51 · see citing works

Global Gene Profiling of Spontaneous Hepatocellular Carcinoma in B6C3F1 Mice

Hoenerhoff, M. J., Pandiri, A. R., Lahousse, S. A., Hong, H.-H., Ton, T.-V., Masinde, T., Auerbach, S. S., Gerrish, K., Bushel, P. R., Shockley, K. R., et al. (2011) · Toxicologic Pathology · doi:10.1177/0192623311407213 · Cited by 46 · see citing works

Pleiotropic Role of p53 in Injury and Liver Regeneration after Acetaminophen Overdose

Borude, P. C., Bhushan, B., Gunewardena, S., Akakpo, J. Y., Jaeschke, H., & Apte, U. M. (2018) · American Journal Of Pathology · doi:10.1016/j.ajpath.2018.03.006 · Cited by 45 · see citing works

Controlling the Stem Cell Compartment and Regeneration In Vivo: The Role of Pluripotency Pathways

Greenow, K. R., & Clarke, A. R. (2012) · Physiological Reviews · doi:10.1152/physrev.00040.2010 · Cited by 44 · see citing works

Clinical Implications of Advances in the Basic Science of Liver Repair and Regeneration

Karp, S. J. (2009) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2009.02731.x · Cited by 43 · see citing works

The cytoprotective Nrf2 transcription factor controls insulin receptor signaling in the regenerating liver

Beyer, T. A., & Werner, S. (2008) · Cell Cycle · doi:10.4161/cc.7.7.5617 · Cited by 44 · see citing works

Does Schistosoma Mansoni Facilitate Carcinogenesis?

von Bülow, V., Lichtenberger, J., Grevelding, C. G., Falcone, F. H., Roeb, E., & Roderfeld, M. (2021) · Cells · doi:10.3390/cells10081982 · Cited by 43 · see citing works

The role of lncRNA MALAT1 in the regulation of hepatocyte proliferation during liver regeneration

Li, C., Chang, L., Chen, Z., Liu, Z., Wang, Y., & Ye, Q. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.2854 · Cited by 43 · see citing works

MicroRNA-203 suppresses proliferation in liver cancer associated with PIK3CA, p38 MAPK, c-Jun, and GSK3 signaling

Zhang, A., Lakshmanan, J., Motameni, A. T., & Harbrecht, B. G. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-3176-9 · Cited by 43 · see citing works

The HBV web: An insight into molecular interactomes between the hepatitis B virus and its host en route to hepatocellular carcinoma

Kar, A., Samanta, A., Mukherjee, S., Barik, S., & Biswas, A. (2022) · Journal of Medical Virology · doi:10.1002/jmv.28436 · Cited by 42 · see citing works

Extracellular ATP and Purinergic P2Y2 Receptor Signaling Promote Liver Tumorigenesis in Mice by Exacerbating DNA Damage

Schulien, I., Hockenjos, B., Marck, V. V., Ayata, C. K., Follo, M., Thimme, R., & Hasselblatt, P. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-1909 · Cited by 42 · see citing works

Cell-delivery therapeutics for liver regeneration☆

Zhang, W., Tucker‐Kellogg, L., Narmada, B. C., Venkatraman, L., Chang, S., Yin, L., Tan, N., White, J., Jia, R., & Bhowmick, S. S. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.02.005 · Cited by 41 · see citing works

Activator protein-1 (AP-1): a bridge between life and death in lung epithelial (A549) cells under hypoxia

Yadav, S., Kalra, N., Ganju, L., & Singh, M. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-3082-1 · Cited by 40 · see citing works

Hepatocyte growth control by SOCS1 and SOCS3

Khan, M. G. M., Ghosh, A., Variya, B. C., Santharam, M. A., Kandhi, R., Ramanathan, S., & Ilangumaran, S. (2019) · Cytokine · doi:10.1016/j.cyto.2019.154733 · Cited by 37 · see citing works

Premature Cell Cycle Entry Induced by Hepatitis B Virus Regulatory HBx Protein during Compensatory Liver Regeneration

Hodgson, A. J., Keasler, V. V., & Slagle, B. L. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2695 · Cited by 37 · see citing works

Oncostatin M Gene Therapy Attenuates Liver Damage Induced by Dimethylnitrosamine in Rats

Hamada, T., Sato, A., Hirano, T., Yamamoto, T., Son, G., Onodera, M., Torii, I., Nishigami, T., Tanaka, M., Miyajima, A., et al. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060972 · Cited by 37 · see citing works

Liver regeneration and liver metastasis

Riddiough, G. E., Jalal, Q., Perini, M. V., & Majeed, A. W. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.05.012 · Cited by 36 · see citing works

Promoter-distal RNA polymerase II binding discriminates active from inactive CCAAT/ enhancer-binding protein beta binding sitesPreprint

Savic, D., Roberts, B. S., Carleton, J. B., Partridge, E. C., White, M. A., Cohen, B. A., Cooper, G. M., Gertz, J., & Myers, R. (2015) · Genome Research · doi:10.1101/gr.191593.115 · Cited by 33 · see citing works

Inhibition of wild‐type p53‐induced phosphatase 1 promotes liver regeneration in mice by direct activation of mammalian target of rapamycin

Zhang, L., Liu, L., He, Z., Li, G., Liu, J., Song, Z., Jin, H., Rudolph, K. L., Yang, H., Mao, Y., et al. (2015) · Hepatology · doi:10.1002/hep.27755 · Cited by 35 · see citing works

Novel therapy for liver regeneration by increasing the number of platelets

Takahashi, K., Murata, S., & Ohkohchi, N. (2012) · Surgery Today · doi:10.1007/s00595-012-0418-z · Cited by 35 · see citing works

Liver cancer development driven by the AP-1/c-Jun~Fra-2 dimer through c-Myc

Bakiri, L., Hasenfuss, S. C., Guío-Carrión, A., Thomsen, M. K., Hasselblatt, P., & Wagner, E. F. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2404188121 · Cited by 34 · see citing works

Loss of caspase-8 in hepatocytes accelerates the onset of liver regeneration in mice through premature nuclear factor kappa B activation

Freimuth, J., Bangen, J., Lambertz, D., Hu, W., Nevzorova, Y. A., Sonntag, R., Gaßler, N., Riethmacher, D., Trautwein, C., & Liedtke, C. (2013) · Hepatology · doi:10.1002/hep.26538 · Cited by 34 · see citing works

Function of Mitogen-Activated Protein Kinases in Hepatic Inflammation

Westenberger, G., Sellers, J., Fernando, S., Junkins, S., Han, S. M., Min, K., & Lawan, A. (2021) · Journal of Cellular Signaling · doi:10.33696/signaling.2.049 · Cited by 31 · see citing works

Zebrafish neurotoxicity from aphantoxins—cyanobacterial paralytic shellfish poisons (PSPs) from Aphanizomenon flos‐aquae DC‐1

Zhang, D., Hu, C., Wang, G., Li, D., Li, G., & Liu, Y. (2011) · Environmental Toxicology · doi:10.1002/tox.20714 · Cited by 29 · see citing works

Specific Activin Receptor–Like Kinase 3 Inhibitors Enhance Liver Regeneration

Tsugawa, D., Oya, Y., Masuzaki, R., Ray, K. C., Engers, D. W., Dib, M. J., Do, N., Kuramitsu, K., Ho, K. J., Frist, A. Y., et al. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.216903 · Cited by 29 · see citing works

Molecular docking and in vitro experiments verified that kaempferol induced apoptosis and inhibited human HepG2 cell proliferation by targeting BAX, CDK1, and JUN

Zhang, Q., Chen, L., Gao, M., Wang, S., Meng, L., & Guo, L. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04546-6 · Cited by 29 · see citing works

Choline Kinase Alpha Is a Novel Transcriptional Target of the Brg1 in Hepatocyte: Implication in Liver Regeneration

Kong, M., Dong, W., Xu, H., Fan, Z., Miao, X., Guo, Y., Li, C., Ye, Q., Wang, Y., & Xu, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.705302 · Cited by 28 · see citing works

MAP Kinase cross talks in oxidative stress‐induced impairment of insulin secretion. Involvement in the protective activity of quercetin

Youl, E., Magous, R., Cros, G. H., & Oiry, C. (2014) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12078 · Cited by 28 · see citing works

The role of p21 in regulating mammalian regeneration

Arthur, L. M., & Heber‐Katz, E. (2011) · Stem Cell Research & Therapy · doi:10.1186/scrt71 · Cited by 29 · see citing works

Acute ethanol preexposure promotes liver regeneration after partial hepatectomy in mice by activating ALDH2

Ding, X., Beier, J. I., Baldauf, K. J., Jokinen, J. D., Zhong, H., & Arteel, G. E. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00085.2013 · Cited by 27 · see citing works

Tob1 is a constitutively expressed repressor of liver regeneration

Ho, K. J., Do, N. L., Otu, H. H., Dib, M. J., Ren, X., Enjyoji, K., Robson, S. C., Terwilliger, E. F., & Karp, S. J. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20092434 · Cited by 27 · see citing works

Hepatic c-Jun regulates glucose metabolism via FGF21 and modulates body temperature through the neural signals

Xiao, F., Guo, Y., Deng, J., Yuan, F., Xiao, Y., Hui, L., Li, Y., Hu, Z., Zhou, Y., Li, K., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.12.003 · Cited by 28 · see citing works

Crosstalk between NLRP12 and JNK during Hepatocellular Carcinoma

Khan, S., & Zaki, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020496 · Cited by 26 · see citing works

Transcriptional profiling of the bovine hepatic response to experimentally induced E. coli mastitis

Jørgensen, H., Buitenhuis, B., Røntved, C. M., Jiang, L., Ingvartsen, K. L., & Sørensen, P. (2012) · Physiological Genomics · doi:10.1152/physiolgenomics.00084.2011 · Cited by 26 · see citing works

Pregnane X Receptor–Humanized Mice Recapitulate Gender Differences in Ethanol Metabolism but Not Hepatotoxicity

Spruiell, K., Gyamfi, A. A., Yeyeodu, S. T., Richardson, R. M., Gonzalez, F. J., & Gyamfi, M. A. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.224295 · Cited by 25 · see citing works

Peptides as Signaling Inhibitors for Mammalian MAP Kinase Cascades

Gaestel, M., & Kracht, M. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788682299 · Cited by 25 · see citing works

Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c‐jun in the liver

Behrens, A., Sibilia, M. C., David, J., Möhle-Steinlein, U., Tronche, F., Schütz, G., & Wagner, E. F. (2002) · The EMBO Journal · doi:10.1093/emboj/21.7.1782 · Cited by 270 · see citing works

Signal transduction during liver regeneration

BRENNER, D. (1998) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.1998.13.s1.93 · Cited by 72 · see citing works

Activation of Jun kinase is an early event in hepatic regeneration.

Westwick, J. K., Weitzel, C., Leffert, H. L., & Brenner, D. A. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117730 · Cited by 148 · see citing works

C–Jun–N–Terminal Kinase Drives Cyclin D1 Expression and Proliferation During Liver Regeneration

Schwabe, R. F., Bradham, C. A., Uehara, T., Hatano, E., Bennett, B. L., Schoonhoven, R., & Brenner, D. A. (2003) · Hepatology · doi:10.1053/jhep.2003.50135 · Cited by 251 · see citing works

Bone marrow-derived c-jun N-terminal kinase-1 (JNK1) mediates liver regeneration

Schaefer, F. M., Peng, J., Hu, W., Drvarov, O., Nevzorova, Y. A., Zhao, G., Masaoudi, M. A., Davis, R. J., Trautwein, C., & Cubero, F. J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.10.011 · Cited by 8 · see citing works