The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Involvement of superoxide radicals in the mouse two‐cell block
Abstract
The effect of oxygen toxicity on the development of mammalian embryos was asssessed by the use of superoxide dismutase (SOD), a potent scavenger of superoxide radicals. Mouse pronuclear embryos recovered 17 h after human chorionic gonadotropin (hCG) were cultured in medium BWW at 37°C under an atmosphere of 5% CO 2 in air. Culture of mouse pronuclear embryos in the presence of Cu ∣ Zn‐SOD (500 μg/ml) significantly increased the blastulation rate (44.6%) when compared with the control culture system (4.2%). Essentially the same effects were observed in SOD containing either Mn or Fe in the catalytic center. Heat treatment of the SOD preparation, and the addition of anti‐SOD antibodies to the culture medium, significantly reduced the attenuation of the two‐cell block by SOD, indicating that this effect is SOD dependent. SOD activity was detected in rabbit oviduct fluid (3,675 ± 3,084 mlU/mg protein) by electron spin resonance. These results suggest that active oxygen is involved in the two‐cell block phenomenon in mouse embryos exposed to air and that SOD in the oviduct may play an important role in the protection of embryos from superoxide radicals.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 317,331
McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952
Methods in Mammalian Embryology
Latshaw, W. K. (1972) · Europe PMC (PubMed Central) · Cited by 1,292
SUCCESSFUL CULTURE IN VITRO OF SHEEP AND CATTLE OVA
TERVIT, H. R., WHITTINGHAM, D. G., & ROWSON, L. E. A. (1972) · Reproduction · doi:10.1530/jrf.0.0300493 · Cited by 1,004
An Enzyme-Based Theory of Obligate Anaerobiosis: The Physiological Function of Superoxide Dismutase
McCord, J. M., Keele, B. B., & Fridovich, I. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.5.1024 · Cited by 973
Handbook of experimental immunology
Emmrich, F. (1986) · Immunology Today · doi:10.1016/0167-5699(86)90032-0 · Cited by 688
Toxic drug effects associated with oxygen metabolism: Redox cycling and lipid peroxidation
Kappus, H., & Sies, H. (1981) · Experientia · doi:10.1007/bf01948335 · Cited by 642
Superoxide Dismutase from Escherichia coli B
Keele, B. B., McCord, J. M., & Fridovich, I. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62675-4 · Cited by 559
Superoxide radical and superoxide dismutase
Fridovich, I. (1972) · Accounts of Chemical Research · doi:10.1021/ar50058a001 · Cited by 469
An Iron-containing Superoxide Dismutase from Escherichia coli
Yost, F. J., & Fridovich, I. (1973) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)43649-1 · Cited by 388
Cited by
Oxygen tension in the oviduct and uterus of rhesus monkeys, hamsters and rabbits
Fischer, B., & Bavister, B. D. (1993) · Reproduction · doi:10.1530/jrf.0.0990673 · Cited by 767
Melatonin and the ovary: physiological and pathophysiological implications
Tamura, H., Nakamura, Y., Korkmaz, A., Manchester, L. C., Tan, D.-X., Sugino, N., & Reiter, R. J. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.05.016 · Cited by 468
Johnson, M. H., & Nasresfahani, M. H. (1994) · BioEssays · doi:10.1002/bies.950160105 · Cited by 342
Oxidative stress may be a piece in the endometriosis puzzle.
Szczepańska, M., Koźlik, J., Skrzypczak, J., & Mikołajczyk, M. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(03)00266-8 · Cited by 269
Oxidative Stress and Redox Regulation on In Vitro Development of Mammalian Embryos
TAKAHASHI, M. (2012) · Journal of Reproduction and Development · doi:10.1262/jrd.11-138n · Cited by 255
Metadata
- Authors
- Noda, Y., Matsumoto, H., Umaoka, Y., Tatsumi, K., Kishi, J., & Mori, T.
- Venue
- Molecular Reproduction and Development
- Publisher
- Wiley
- Published
- 1991-04
- Volume
- 28
- Issue
- 4
- Pages
- 356-360
- ISSN
- 1040-452X (ISSN-L)
- 1098-2795
- OpenAlex
- W2095024931
- Cited by
- 260
- References
- 23
- FWCI
- 25.70
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Involvement of superoxide radicals in the mouse two‐cell block. https://app.cochat.ai/papers/10.1002/mrd.1080280408
- The paper
- Noda, Y., Matsumoto, H., Umaoka, Y., Tatsumi, K., Kishi, J., & Mori, T. (1991). Involvement of superoxide radicals in the mouse two‐cell block. Molecular Reproduction and Development. https://doi.org/10.1002/mrd.1080280408
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
