Oxidative stress may be a piece in the endometriosis puzzle.
Open accessAbstract
Objective To assess the total antioxidant potential of women with endometriosis-associated infertility, women with idiopathic infertility, and fertile controls. Design Retrospective study. Setting University medical hospital. Patient(s) Sixty-five women admitted for diagnostic laparoscopy. Main outcome measures Peritoneal fluid samples were analyzed for superoxide dismutase activity and total antioxidant status on spectrophotometry, glutathione peroxidase activity on enzyme-linked immunosorbent assay, and lipid peroxides levels on colorimetry. Result(s) Mean activity of superoxide dismutase, glutathione peroxidase, and total antioxidant status was lowest and lipid peroxide level was highest among infertile patients with endometriosis. Women with idiopathic infertility, in contrast, had the highest superoxide dismutase, glutathione peroxidase, and total antioxidant status activity and the lowest lipid peroxide level. Conclusion(s) High antioxidant potential is not a contributing factor in women with idiopathic infertility. Low total antioxidant status and low activity of antioxidant enzymes in the peritoneal fluid of infertile women with endometriosis probably do not influence fertility in these women, but these factors may play a role in the development of the disease.
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Preeclampsia, miscarriages, preterm labour, birth defects, endometriosis, tubal factor infertility, intrauterine growth retardation, and stillbirth have been linked to insufficient trophoblast invasion, development, vascular remodeling, and impaired placental development and function.
“Preeclampsia, miscarriages, preterm labour, birth defects, endometriosis and tubal factor infertility, intrauterine growth retardation and stillbirth have been linked to insufficient trophoblast invasion, development, vascular remodeling and impaired placental development and function (Jauniaux et al., 2003, Szczepanska et al., 2003, Pringle et al, 2010)”
From Iron, Oxidative Stress and Health (2012) · cites this paper as Szczepanska et al., 2003
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“…to insufficient trophoblast invasion, development, vascular remodeling and impaired placental development and function (Jauniaux et al., 2003, Szczepanska et al., 2003, Pringle et al, 2010) In the event of placental hypoxia, due to defective placentation, ischemicreperfusion injury occurs…”
Background
- Authors
- Szczepańska, M., Koźlik, J., Skrzypczak, J., & Mikołajczyk, M.
- Affiliations
- Poznan University of Medical Sciences (PL)
- Corresponding author
- Mikołajczyk, Mateusz
- ORCID
- Mikołajczyk, Mateusz
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2003-06
- Volume
- 79
- Issue
- 6
- Pages
- 1288-1293
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2052656267
- Cited by
- 269
- References
- 1
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 13 · 2023: 17 · 2022: 10 · 2021: 13 · 2020: 13 · 2019: 9 · 2018: 12 · 2017: 16 · 2016: 9 · 2015: 13 · 2014: 18 · 2013: 23 · 2012: 19
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- endometriosis, oxidative stress, endometriosis-associated infertility, unexplained infertility, total antioxidant status, superoxide dismutase, glutathione peroxidase, lipid peroxidation, peritoneal fluid, antioxidant enzymes
- MeSH terms
- Ascitic Fluid, Endometriosis, Female, Glutathione Peroxidase, Humans, Infertility, Lipid Peroxides, Retrospective Studies, Superoxide Dismutase, Oxidative Stress
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