The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Sperm selection capacity of the human zona pellucida
Abstract
Previous hemizona assay (HZA) results have illustrated a positive and significant correlation between the percentage of morphologically normal spermatozoa in the semen and the number of spermatozoa tightly bound to the zona pellucida. The present study was designed to evaluate the morphologic features using strict criteria of spermatozoa tightly bound to the zona pellucida. Semen samples of 4 normozoospermic and 11 teratozoospermic men were used to compare the percentage of normal spermatozoa in the semen with that found 1) after swim-up separation and 2) bound to the zona under HZA conditions. The mean (+/- SEM) % normal forms for normozoospermic men in semen, after swim-up and zona-bound spermatozoa were 21.5 +/- 1.6, 27.5 +/- 2.9, and 44.8 +/- 3.4, respectively. A significantly higher % of normal forms were found among zona-bound sperm compared to swim-up forms (p = 0.02) and seminal sperm (p = 0.02). The mean % of normal sperm forms present in semen, after swim-up and zona pellucida-binding for teratozoospermic men, were 3.7 +/- 0.9, 5.8 +/- 1.6 and 15.6 +/- 3.1, respectively. Significant differences existed between the % of normal sperm forms found in the swim-up and zona-bound spermatozoa (P = less than 0.01 and P = less than 0.0003, respectively) compared to the original ejaculates. Results indicate that a selective process against abnormal spermatozoa occurs at the site of the zona pellucida.(ABSTRACT TRUNCATED AT 250 WORDS)
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This approach was based on the observation that the morphology of spermatozoa in the cervical mucus was better than those from the semen sample and similar to the morphology required for binding to zona pellucida (28,29).”
From Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review (2024) · cites this paper as [28]
Citations
Cites
Sperm morphologic features as a prognostic factor in in vitro fertilization
Kruger, T. F., Menkveld, R., Stander, F. S. H., Lombard, C. J., Van der Merwe, J. P., van Zyl, J. A., & Smith, K. (1986) · Fertility and Sterility · doi:10.1016/s0015-0282(16)49891-2 · Cited by 1,208
Self-citationAitken, R. J., & Clarkson, J. S. (1988) · Journal of Andrology · doi:10.1002/j.1939-4640.1988.tb01067.x · Cited by 784
A New Procedure for Staining Vaginal Smears
Papanicolaou, G. N. (1942) · Science · doi:10.1126/science.95.2469.438 · Cited by 680
The evaluation of morphological characteristics of human spermatozoa according to stricter criteria
Menkveld, R., Stander, F. S. H., Kotze, T. J. V., Kruger, T. F., & Zyl, J. A. V. (1990) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137150 · Cited by 677
Self-citationBurkman, L. J., Coddington, C. C., Franken, D. R., Kruger, T. F., Rosenwaks, Z., & Hodgen, G. D. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)59841-0 · Cited by 391
Self-citationAitken, R. J., Clarkson, J. S., Hargreave, T. B., Irvine, D. S., & Wu, F. C. W. (1989) · Journal of Andrology · doi:10.1002/j.1939-4640.1989.tb00091.x · Cited by 332
ELIASSON, R. (2009) · Andrologia · doi:10.1111/j.1439-0272.1971.tb01125.x · Cited by 246
Oehninger, S., Acosta, A. A., Morshedi, M., Veeck, L. L., Swanson, R. J., Simmons, K. E., & Rosenwaks, Z. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)60074-2 · Cited by 200
Self-citationPenetration of the Zona Pellucida of Nonliving Human Oocytes by Human Spermatozoa in Vitro
Overstreet, J. W., & Hembree, W. C. (1976) · Fertility and Sterility · doi:10.1016/s0015-0282(16)41959-x · Cited by 171
A human sperm-zona pellucida binding test using oocytes that failed to fertilize in vitro
Liu, D. Y., Lopata, A., Johnston, W. I. H., & Baker, H. W. G. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)60316-3 · Cited by 149
Franken, D. R., Oehninger, S., Burkman, L. J., Coddington, C. C., Kruger, T. F., Rosenwaks, Z., Acosta, A. A., & Hodgen, G. D. (1989) · Journal of Assisted Reproduction and Genetics · doi:10.1007/bf01134581 · Cited by 128
Self-citationHemizona assay: assessment of sperm dysfunction and prediction of in vitro fertilization outcome
Oehninger, S., Coddington, C. C., Franken, D. R., Scott, R. T., Burkman, L. J., Acosta, A. A., & Hodgen, G. D. (1989) · Fertility and Sterility · doi:10.1016/s0015-0282(16)60618-0 · Cited by 122
Self-citationDifferences in the Movement of Morphologically Normal and Abnormal Human Seminal Spermatozoa
Katz, D. F., Diel, L., & Overstreet, J. W. (1982) · Biology of Reproduction · doi:10.1095/biolreprod26.4.566 · Cited by 111
Spermatozoa, Antibodies and Infertility
Morton, D. B. (1980) · Journal of Reproductive Immunology · doi:10.1016/0165-0378(80)90009-1 · Cited by 109
Liu, D. Y., & Baker, H. W. G. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)60075-4 · Cited by 106
Deep-freezing and transfer of human embryos
Mohr, L. R., Trounson, A. O., & Freemann, L. (1985) · Journal of Assisted Reproduction and Genetics · doi:10.1007/bf01130825 · Cited by 99
Morphological selection of human spermatozoa in vivo and in vitro
Mortimer, D., Leslie, E. E., Kelly, R. W., & Templeton, A. A. (1982) · Reproduction · doi:10.1530/jrf.0.0640391 · Cited by 97
The interaction of human spermatozoa with cervical mucus in vivo
Hanson, F. W., & Overstreet, J. W. (1981) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(81)90105-8 · Cited by 80
Mechanisms of filtration of morphologically abnormal human sperm by cervical mucus
Katz, D. F., Morales, P. J., Samuels, S. J., & Overstreet, J. W. (1990) · Fertility and Sterility · doi:10.1016/s0015-0282(16)53772-8 · Cited by 66
Oehninger, S., ACOSTA, R., Morshedi, M., Philput, C. B., Swanson, R. J., & Acosta, A. A. (1990) · Journal of Andrology · doi:10.1002/j.1939-4640.1990.tb00174.x · Cited by 64
Self-citationMechanisms of filtration of morphologically abnormal human sperm by cervical mucus
Katz, D. F., Morales, P. J., Samuels, S., & Overstreet, J. W. (1991) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(91)90311-r · Cited by 63
Human sperm—zona pellucida binding, sperm characteristics and in-vitro fertilization
Liu, D. Y., Lopata, A. L., Johnston, W. I. H., & Baker, H. W. G. (1989) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a136969 · Cited by 60
Human Spermatozoa in Assisted Reproduction
Klein, T. A. (1990) · Military Medicine · doi:10.1093/milmed/155.10.a15e · Cited by 57
The Relationship Between the Motility and Morphology of Spermatozoa in Human Semen
Morales, P. J., Katz, D. F., Overstreet, J. W., Samuels, S., & Chang, R. J. (1988) · Journal of Andrology · doi:10.1002/j.1939-4640.1988.tb01045.x · Cited by 56
Binding of morphologically abnormal sperm to mouse egg zonae pellucidae in vitro
Kot, M. C., & Handel, M. A. (1987) · Gamete Research · doi:10.1002/mrd.1120180107 · Cited by 52
Influence of egg investments on in-vitro penetration of mouse eggs by misshapen spermatozoa
KRZANOWSKA, H., & Lorenc, E. (1983) · Reproduction · doi:10.1530/jrf.0.0680057 · Cited by 52
Coddington, C. C., Fulgham, D. L., Alexander, N. J., Johnson, D. E., Herr, J. C., & Hodgen, G. D. (1990) · Fertility and Sterility · doi:10.1016/s0015-0282(16)53770-4 · Cited by 46
Self-citationAtlas of human sperm morphology
Menkveld, R. (1991) · Williams & Wilkins eBooks · Cited by 43
Self-citationFranken, D. R., Coddington, C. C., Burkman, L. J., Oosthuizen, W. T., Oehninger, S., Kruger, T. F., & Hodgen, G. D. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54732-3 · Cited by 43
Self-citationMahadevan, M. M., Trounson, A. O., Wood, C. E., & LEETON, J. F. (1987) · Journal of Assisted Reproduction and Genetics · doi:10.1007/bf01533760 · Cited by 33
Jackson, K. V., & Kiessling, A. A. (1989) · Fertility and Sterility · doi:10.1016/s0015-0282(16)60620-9 · Cited by 32
Analysis of human spermatozoa before and after processing for in vitro fertilization
McDowell, J. S., Veeck, L. L., & Jones, H. W. (1985) · Journal of Assisted Reproduction and Genetics · doi:10.1007/bf01130828 · Cited by 27
On the Morphology of Live Spermatozoa of Human Semen
Fredricsson, B., Waxegård, G., Brege, S., & Lundberg, I. (1977) · Fertility and Sterility · doi:10.1016/s0015-0282(16)42377-0 · Cited by 20
Scott, R. T., Oehninger, S., Menkveld, R., Veeck, L. L., & Acosta, A. A. (1989) · Archives of Andrology · doi:10.3109/01485018908986834 · Cited by 19
Self-citationCourtot, A. M., Escalier, D., Jouannet, P., & David, G. (1987) · Gamete Research · doi:10.1002/mrd.1120170206 · Cited by 15
The infertile couple. Part II. Examination and evaluation of semen.
Zyl, J. A. V. (1980) · PubMed · Cited by 13
Research works printed but not linked: 3
- FrankenDR OosthuizenWT CooperS KrugerTF BurkmanLJ CoddingtonCC HodgenGD(1991aa): Electron microscopic evidence on the acrosomal status of bound sperm and their penetration to human hemizona pellucida after storage in a buffered salt solution.Andrologia(in press).
- van Zyl JA, 1990, Human Spermatozoa in Assisted Reproduction, 319
- World Health Organization, 1987, WHO Laboratory Manual for the Examination of Human Semen and Semen‐Cervical Mucus Interaction, 32
Cited by
Sorted by citations
Sperm DNA fragmentation: paternal effect on early post-implantation embryo development in ART
Borini, A., Tarozzi, N., Bizzaro, D., Bonu, M. A., Fava, L., Flamigni, C., & Coticchio, G. (2006) · Human Reproduction · doi:10.1093/humrep/del251 · Cited by 462
Lewis, S. E. M., Aitken, R. J., Conner, S. J., Iuliis, G. N. D., Evenson, D. P., Henkel, R., Giwercman, A., & Gharagozloo, P. (2013) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2013.06.014 · Cited by 292
Predictive value of normal sperm morphology: a structured literature review
Coetzee, K. (1998) · Human Reproduction Update · doi:10.1093/humupd/4.1.73 · Cited by 253
Fertility testing and ICSI sperm selection by hyaluronic acid binding: clinical and genetic aspects
Huszar, G. B., Jakab, A., Sakkas, D., Özenci, Ç. Ç., Çaylı, S., Delpiano, E. M., & Özkavukçu, S. (2007) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)61060-7 · Cited by 228
Menkveld, R. (2010) · Asian Journal of Andrology · doi:10.1038/aja.2009.14 · Cited by 194
Self-citation
Metadata
- Authors
- Menkveld, R., Franken, D. R., Kruger, T. F., Oehninger, S., & Hodgen, G. D.
- Affiliations
- Tygerberg Hospital (ZA)
- Eastern Virginia Medical School (US)
- Corresponding author
- Oehninger, Sergio
- Venue
- Molecular Reproduction and Development
- Publisher
- Wiley
- Published
- 1991-12
- Volume
- 30
- Issue
- 4
- Pages
- 346-352
- ISSN
- 1040-452X (ISSN-L)
- 1098-2795
- OpenAlex
- W1970974034
- Cited by
- 129
- References
- 36
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 4 · 2017: 12 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 7 · 2012: 4
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Reproduction and Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- zona pellucida, sperm selection, teratozoospermia, sperm morphology, hemizona assay
- MeSH terms
- Cell Separation, Female, Humans, Male, Semen, Sperm-Ovum Interactions, Spermatozoa, Zona Pellucida
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
