Sperm morphologic features as a prognostic factor in in vitro fertilization
Open accessAbstract
To determine whether there is a prognostic value in the percentage normal sperm morphologic features in a human in vitro fertilization (IVF) program, the authors conducted a prospective study in women with bilateral tubal damage. Based on the percentage of morphologically normal spermatozoa, the patients were divided into four groups: group I, normal morphologic features between 0% and 14%; group II, 15% to 30%; group III, 31% to 45%; and group IV, 46% to 60%. One hundred ninety successful laparoscopic cycles were evaluated. In group I, 104 oocytes were obtained, of which 37% fertilized, but no pregnancy resulted; in group II, 81% of 324 oocytes were fertilized, with a pregnancy rate per embryo transfer (ET) of 22%; in group III, 82% of 309 oocytes were fertilized, with a 31% pregnancy rate; and in group IV, 91% of 69 oocytes were fertilized, with a pregnancy rate of 12%. Probability models indicated that there was a clear threshold in normal sperm morphologic features at 14%, with high fertilization and pregnancy rate in the groups with normal sperm morphologic features greater than 14%.
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In 1986, Kruger et al. published a classification system to evaluate sperm morphology and correlate it with the likelihood of IVF outcomes in terms of fertilization and clinical pregnancy.
“In 1986, Kruger et al.2 published a novel classification system to evaluate sperm morphology and correlate it with the likelihood of IVF outcomes in terms of fertilization and clinical pregnancy.”
From Men with a complete absence of normal sperm morphology exhibit high rates of success without assisted reproduction (2017) · cites this paper as [2]
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- Authors
- Kruger, T. F., Menkveld, R., Stander, F. S. H., Lombard, C. J., Van der Merwe, J. P., van Zyl, J. A., & Smith, K.
- Affiliations
- Tygerberg Hospital (ZA)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 1986-12
- Volume
- 46
- Issue
- 6
- Pages
- 1118-1123
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W1989070741
- Cited by
- 1,208
- References
- 0
- Citations by year
- 2026: 8 · 2025: 30 · 2024: 11 · 2023: 15 · 2022: 16 · 2021: 23 · 2020: 18 · 2019: 27 · 2018: 29 · 2017: 34 · 2016: 24 · 2015: 31 · 2014: 26 · 2013: 55 · 2012: 50
- FWCI
- 9.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- SUNScholar (Stellenbosch University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- sperm morphology, in vitro fertilization, prognostic factors, tubal damage, fertilization rate, pregnancy rate, embryo transfer, oocyte fertilization, probability models, cut-off values
- MeSH terms
- Embryo Transfer, Female, Fertilization in Vitro, Humans, Male, Menstrual Cycle, Oocytes, Laparoscopy, Pregnancy, Prognosis, Prospective Studies, Sperm Count, Sperm Motility, Spermatozoa
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