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Cited by 203Childhood Cancer Survivors' Quality of LifeCancer-related cognitive impairment studiesAcute Lymphoblastic Leukemia research

Neurocognitive effects of treatment for childhood cancer

Butler, Robert W., Haser, Jennifer K.·2006·Mental Retardation and Developmental Disabilities Research Reviews
DOI 10.1002/mrdd.20110
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Abstract

We review research on the neuropsychological effects that central nervous system (CNS) cancer treatments have on the cognitive abilities of children and adolescents. The authors focus on the two most common malignancies of childhood: leukemias and brain tumors. The literature review is structured so as to separate out earlier studies, generally those published prior to 1995, as opposed to manuscripts that have been published within the past decade. This is an important distinction for both leukemia and brain tumors. Earlier studies were ground breaking in that they began to map out what could be expected in terms of intelligence and academic problems in survivors of pediatric malignancies. Survivorship in this population has and continues to markedly increase and this is largely due to changes in treatment protocols. Research on neurocognitive effects of disease and treatment in pediatric oncology has become increasingly sophisticated, and this literature review not only reflects this trend, but highlights the growing collaboration between neuropsychology, cognitive neuroscience, and neuro-imaging. Thus, our goal was to provide a historical foundation, lead the reader towards the progression of research methodology up to the current state of the art, and perhaps most importantly, discuss future directions. These directions are especially relevant to the concepts of remediation and treatment of cognitive problems, and this is emphasized at the conclusion of the review.

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Crossref · 10.1002/mrdd.20110

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  • Ionizing radiation can damage the CNS, causing changes to cognitive function, inducing fatigue, and generating performance decrements.

    “Ionizing radiation can damage the CNS, causing changes to cognitive function, inducing fatigue, and generating performance decrements [2,30,42,43,44,45,46,47,48,49,50,51].”

    From Space Radiation: The number one risk to astronaut health beyond low earth orbit (2014) · cites this paper as [42]

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Authors
Butler, R. W., & Haser, J. K.
Affiliations
Oregon Health & Science University (US)
Corresponding author
Butler, Robert W.
Venue
Mental Retardation and Developmental Disabilities Research Reviews
Publisher
Wiley
Published
2006-01
Volume
12
Issue
3
Pages
184-191
ISSN
  • 1080-4013 (ISSN-L)
  • 1098-2779
DOI
10.1002/mrdd.20110
OpenAlex
W2045533008
Cited by
203
References
78
Citations by year
2026: 4 · 2025: 5 · 2024: 6 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 9 · 2018: 6 · 2017: 10 · 2016: 13 · 2015: 18 · 2014: 18 · 2013: 13 · 2012: 15
FWCI
1.83
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 295 d)
Locations
  • Mental Retardation and Developmental Disabilities Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (R01CA083936, R01 CA83936)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
Keywords
neurocognitive effects, childhood cancer, central nervous system cancer, pediatric leukemia, brain tumors, cancer survivors, intelligence, academic difficulties, cognitive remediation, neuropsychology, cognitive neuroscience, neuroimaging
MeSH terms
Antineoplastic Agents, Brain Neoplasms, Child, Developmental Disabilities, Cognition Disorders, Combined Modality Therapy, Humans, Injections, Spinal, Intellectual Disability, Methotrexate, Cranial Irradiation, Precursor Cell Lymphoblastic Leukemia-Lymphoma

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