Chemotherapy-only treatment effects on long-term neurocognitive functioning in childhood ALL survivors: a review and meta-analysis
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Key Points: Children treated for ALL without cranial radiation display significant IQ deficits of 6 to 8 points compared with healthy controls. Moderate deficits occur in other neurocognitive domains including working memory, information processing speed, and fine motor functioning.
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Neurocognitive and behavioral late effects of childhood ALL treatment include weaknesses in working memory, visual-spatial reasoning, motor coordination, processing speed, and attention.
“Neurocognitive and behavioral late effects include weaknesses in working memory, visual‐spatial reasoning, motor coordination, processing speed, and attention (Campbell et al., 2009; Iyer, Balsamo, Bracken, & Kadan‐lottick, 2015; Jacola et al., 2016; Peterson et al., 2008).”
From Brain structure, working memory and response inhibition in childhood leukemia survivors (2017) · cites this paper as Iyer, Balsamo, Bracken, & Kadan‐lottick, 2015
The Working memory, Information processing speed, and Fine motor functioning sections report weaknesses in childhood ALL survivors treated without cranial radiation. The Attention/concentration section reports mixed results and a nonsignificant pooled effect; the Visuoconstruction section does not establish a weakness in visual-spatial reasoning. The cited review therefore supports only part of the list. Page numbers were not available in our copy. (LLM, conf=0.88)
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- Authors
- Iyer, N. S., Balsamo, L. M., Bracken, M. B., & Kadan-Lottick, N. S.
- Affiliations
- Lake Erie College of Osteopathic Medicine (US)
- Yale Cancer Center (US)
- Yale University (US)
- Pediatric Hematology/Oncology, Yale School of Medicine and Yale Cancer Center, New Haven, CT; and
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2015-07-16
- Volume
- 126
- Issue
- 3
- Pages
- 346-353
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1888049586
- Cited by
- 194
- References
- 66
- Citations by year
- 2026: 14 · 2025: 11 · 2024: 14 · 2023: 16 · 2022: 9 · 2021: 27 · 2020: 20 · 2019: 22 · 2018: 17 · 2017: 19 · 2016: 20 · 2015: 4
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Funders
- St. Baldrick's Foundation
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Childhood Cancer Survivors' Quality of Life
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- childhood acute lymphoblastic leukemia, cognitive impairment, intelligence quotient, verbal IQ, performance IQ, working memory, processing speed, fine motor skills, cancer survivors
- MeSH terms
- Antineoplastic Combined Chemotherapy Protocols, Brain Neoplasms, Child, Cognition Disorders, Humans, Survival Rate, Survivors, Precursor Cell Lymphoblastic Leukemia-Lymphoma
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