Maturation of the human fetal brain as observed by 1H MR spectroscopy
Open accessAbstract
Proton MRS was used to monitor cerebral metabolite tissue levels in 35 normal fetuses during development in the gestational age range of 30–41 weeks. First, MRI in three orthogonal orientations was performed. A volume of interest (VOI) (15–43 cc) of fetal brain tissue was then selected for 1 H MRS. For localization, two pulse sequences (stimulated echo acquisition mode (STEAM) at TE = 20 ms, and point‐resolved spectroscopy (PRESS) at TE = 135 ms) were applied. The MR spectra of the brain showed signals for inositol (Ino), choline (Cho), creatine (Cr), and N‐acetyl (NA) compounds. From 30 to 41 weeks the absolute tissue level of NA, and the ratios of NA/Cr and NA/Cho increased, whereas the ratio of Cho/Cr decreased. These changes reflect maturation of the brain. Considering the diagnostic value of proton MRS in pediatric neurology, this new approach may also be useful for characterizing pathological conditions in the fetal brain. Magn Reson Med 48:611–616, 2002. © 2002 Wiley‐Liss, Inc.
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Choline:creatine and N-acetyl aspartate:choline ratios were calculated only when MR spectra met a reliable fit criterion of standard deviation below 20% for each metabolite.
“Cho:Cr and NAA:Cho ratios were calculated when MR spectra satisfied a reliable fit with a standard deviation <20% for each metabolite [27].”
From Brain Volume and Metabolism in Fetuses With Congenital Heart Disease: Evaluation With Quantitative Magnetic Resonance Imaging and Spectroscopy (2010) · cites this paper as [27]
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- Authors
- Kok, R. D., van den Berg, P. P., van den Bergh, A. J., Nijland, R., & Heerschap, A.
- Affiliations
- Radboud University Nijmegen (NL)
- Corresponding author
- Kok, René D.
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 2002-09-26
- Volume
- 48
- Issue
- 4
- Pages
- 611-616
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W2010731661
- Cited by
- 129
- References
- 25
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2021: 6 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 10 · 2014: 6 · 2013: 6 · 2012: 12
- FWCI
- 4.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Magnetic Resonance in Medicine (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- fetal brain maturation, human fetal brain, brain metabolites, choline, creatine, myo-inositol, gestational age, fetal brain development
- MeSH terms
- Aspartic Acid, Brain, Choline, Creatine, Dipeptides, Female, Fetus, Gestational Age, Humans, Inositol, Magnetic Resonance Spectroscopy, Pregnancy
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