Assessment of normal fetal brain maturation in utero by proton magnetic resonance spectroscopy
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Cerebral maturation in the normal human fetal brain was investigated by in utero localized proton MR spectroscopy (1 H MRS). Fifty‐eight subjects at 22–39 weeks of gestational age (GA) were explored. A combination of anterior body phased‐array coils (four elements) and posterior spinal coils (two to three elements) was used. Four sequences were performed (point‐resolved spectroscopy (PRESS) sequence with short and long TEs (30 and 135 ms), with and without water saturation). A significant reduction in myo‐inositol (myo‐Ins) and choline (Cho) levels, and an increase in N‐acetylaspartate (NAA) and creatine (Cr) content were observed with progressing age. A new finding is the detection of NAA as early as 22 weeks of GA. This result is probably related to the fact that oligodendrocytes (whether mature or not) express NAA, as demonstrated by in vitro studies. Cho and myo‐inositol were the predominant resonances from 22 to 30 weeks and decreased gradually, probably reflecting the variations in substrate needed for membrane synthesis and myelination. The normal MRS data for the second trimester of gestation (when fetal MRI is usually performed) reported here can help determine whether brain metabolism is altered or not, especially when subtle anatomic changes are observed on conventional images. Magn Reson Med, 2006. © 2006 Wiley‐Liss, Inc.
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N-acetyl aspartate increases with gestational age and decreases with brain injury, and reflects the development of dendrites and synapses as well as oligodendrocyte proliferation and differentiation.
“NAA increases with GA and decreases with brain injury [24], and reflects not only the development of dendrites and synapses but also oligodendrocyte proliferation and differentiation [36].”
From Brain Volume and Metabolism in Fetuses With Congenital Heart Disease: Evaluation With Quantitative Magnetic Resonance Imaging and Spectroscopy (2010) · cites this paper as [24]
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- Kok RD, van den Berg PP, van den Bergh AJ, Nijland R, Heerschap A. Maturation of the human fetal brain as observed by 1H MR spectros- copy. Magn Reson Med 2002;48:611-616.
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- Authors
- Girard, N., Gouny, S. C., Viola, A., Le Fur, Y., Viout, P., Chaumoitre, K., D'Ercole, C., Gire, C., Figarella‐Branger, D., & Cozzone, P. J.
- Affiliations
- Assistance Publique Hôpitaux de Marseille (FR)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Girard, Nadine
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 2006-09-08
- Volume
- 56
- Issue
- 4
- Pages
- 768-775
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W2023439888
- Cited by
- 111
- References
- 39
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 8 · 2020: 2 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 7 · 2015: 12 · 2014: 8 · 2013: 6 · 2012: 8
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Magnetic Resonance in Medicine (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Keywords
- fetal brain maturation, myo-inositol, choline, N-acetylaspartate, creatine, oligodendrocytes, myelination, second trimester, gestational age, fetal brain metabolism, PRESS sequence
- MeSH terms
- Aging, Algorithms, Aspartic Acid, Brain, Brain Chemistry, Female, Gestational Age, Humans, Magnetic Resonance Spectroscopy, Pregnancy, Linear Models, Fetal Development
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