The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Development of the human brain: In vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy
Abstract
Cerebral metabolite concentrations and water content were measured by means of localized proton magnetic resonance spectroscopy in 50 children, while metabolite peak ratios in short echo time spectra were evaluated in 173 examinations. Normative curves for normal development were established for two cerebral locations. The current report presents the first study of absolute metabolite concentrations and T1‐and T2‐relaxation as a function of age. Myo‐inositol was found dominating the spectra at birth (12 mmoles/kg), while choline is responsible for the strongest peak in older infants (2.5 mmoles/kg). Creatine and N‐acetyl groups are at significantly lower concentrations in the neonate than in the adult (Cr: 6, NA: 5 mmoles/kg). NA and Cr are determined by gestational age, whereas the concentration of ml correlates best with postnatal age. Quantitative l H MRS is expected to be of particular value in diagnosis and monitoring of pathology in infants, since metabolite ratios are often misleading.
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Citations
Cites
Quantitative growth and development of human brain
Dobbing, J., & Sands, J. (1973) · Archives of Disease in Childhood · doi:10.1136/adc.48.10.757 · Cited by 1,442
Cited by
Normal development of brain circuits
Tau, G. Z., & Peterson, B. S. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.115 · Cited by 1,391
Magnetic Resonance Spectroscopy
Gujar, S. K., Maheshwari, S., Bj??rkman-Burtscher, I., & Sundgren, P. C. (2005) · Journal of Neuro-Ophthalmology · doi:10.1097/01.wno.0000177307.21081.81 · Cited by 380
Magnetic Resonance Imaging of Myelin
Laule, C., Vavasour, I. M., Kolind, S. H., Li, D. K. B., Traboulsee, T. L., Moore, G. R. W., & MacKay, A. L. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.05.004 · Cited by 334
Long-term follow-up after gene therapy for canavan disease
Leone, P., Shera, D., McPhee, S. W. J., Francis, J. S., Kolodny, E. H., Bilaniuk, L. T., Wang, D.-J., Assadi, M., Goldfarb, O., Goldman, H. W., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003454 · Cited by 307
Harris, A. D., Puts, N. A. J., & Edden, R. A. E. (2015) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.24903 · Cited by 306
Metadata
- Authors
- Kreis, R., Ernst, T., & Ross, B. D.
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 1993-10
- Volume
- 30
- Issue
- 4
- Pages
- 424-437
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W1969348807
- Cited by
- 681
- References
- 1
- FWCI
- 16.65
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kreis, R., Ernst, T., & Ross, B. D. (1993). Development of the human brain: In vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy. Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.1910300405
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
