The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Tissue correction for GABA‐edited MRS: Considerations of voxel composition, tissue segmentation, and tissue relaxations
Open accessAbstract
Purpose: To develop a tissue correction for GABA‐edited magnetic resonance spectroscopy (MRS) that appropriately addresses differences in voxel gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) fractions. Materials and Methods: Simulations compared the performance of tissue correction approaches. Corrections were then applied to in vivo data from 16 healthy volunteers, acquired at 3T. GM, WM, and CSF fractions were determined from T1‐weighted images. Corrections for CSF content, GM/WM GABA content, and water relaxation of the three compartments are combined into a single, fully corrected measurement. Results: Simulations show that CSF correction increases the dependence of GABA measurements on GM/WM fraction, by an amount equal to the fraction of CSF. Furthermore, GM correction substantially (and nonlinearly) increases the dependence of GABA measurements on GM/WM fraction, for example, by a factor of over four when the voxel GM tissue fraction is 50%. At this tissue fraction, GABA is overestimated by a factor of 1.5. For the in vivo data, correcting for voxel composition increased measured GABA values (P < 0.001 for all regions), but did not reduce intersubject variance (P > 0.5 for all regions). Corrected GABA values differ significantly based on the segmentation procedure used (P < 0.0001) and tissue parameter assumptions made (P < 0.0001). Conclusion: We introduce a comprehensive tissue correction factor that adjusts GABA measurements to correct for different voxel compositions of GM, WM, and CSF. J. Magn. Reson. Imaging 2015;42:1431–1440.
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Cites
STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT
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T1, T2 relaxation and magnetization transfer in tissue at 3T
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Simultaneousin vivo spectral editing and water suppression
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Polarity-Sensitive Modulation of Cortical Neurotransmitters by Transcranial Stimulation
Stagg, C. J., Best, J. G., Stephenson, M. C., O'Shea, J., Wylezinska, M., Kincses, Z. T., Morris, P. G., Matthews, P. M., & Johansen-Berg, H. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4432-08.2009 · Cited by 941
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Self-citationCurrent practice in the use of MEGA-PRESS spectroscopy for the detection of GABA
Mullins, P. G., McGonigle, D. J., O'Gorman, R. L., Puts, N. A. J., Vidyasagar, R., Evans, C. J., & Edden, R. A. E. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2012.12.004 · Cited by 553
Self-citationUse of tissue water as a concentration reference for proton spectroscopic imaging
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Cited by
Reduced GABA and altered somatosensory function in children with autism spectrum disorder
Puts, N. A. J., Wodka, E. L., Harris, A. D., Crocetti, D., Tommerdahl, M., Mostofsky, S. H., & Edden, R. A. E. (2017) · Autism Research · doi:10.1002/aur.1691 · Cited by 265
Self-citationHone-Blanchet, A., Edden, R. A., & Fecteau, S. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.11.008 · Cited by 110
Self-citationReduced striatal GABA in unmedicated children with ADHD at 7T
Puts, N. A., Ryan, M., Oeltzschner, G., Horska, A., Edden, R. A. E., & Mahone, E. M. (2020) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2020.111082 · Cited by 65
Self-citationPierce, S., Kadlaskar, G., Edmondson, D. A., McNally Keehn, R., Dydak, U., & Keehn, B. (2021) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-020-09351-0 · Cited by 42
Flores-Ramos, M., Alcauter, S., López-Titla, M., Bernal-Santamaría, N., Calva-Coraza, E., & Edden, R. A. E. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.08.033 · Cited by 21
Metadata
- Authors
- Harris, A. D., Puts, N. A. J., & Edden, R. A. E.
- Venue
- Journal of Magnetic Resonance Imaging
- Publisher
- Wiley
- Published
- 2015-07-14
- Volume
- 42
- Issue
- 5
- Pages
- 1431-1440
- ISSN
- 1053-1807 (ISSN-L)
- 1522-2586
- OpenAlex
- W1901260206
- Cited by
- 306
- References
- 31
- FWCI
- 10.84
- Type
- journal article
- Language
- en
- Open access
- green
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