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Analysis of macromolecule resonances in 1H NMR spectra of human brain
Abstract
Macromolecule resonances underlying metabolites in 1 H NMR spectra were investigated in temporal lobe biopsy tissue from epilepsy patients and from localized 1 H spectra of the brains of healthy volunteers. The 1 H NMR spectrum of brain tissue was cornpared with that of cytosol and dialyzed cytosol after removal of low molecular weight molecules (4500 daltons) at 8.4 and 2.1 Tesla. The assignment of specific resonances to macromolecules in 2.1 Tesla, short‐ TE, localized human brain 1 H NMR spectra in vivo was made on the basis of a J‐editing method using the spectral parameters (δ, J) and connectivities determined from 2D experiments in vitro. Two prominent corinectivities associated with macromolecules in vitro (0.93–2.05 δ and 1.6–3.00 δ) were also detected in vivo by the J‐editing method. Advantage was taken of the large difference in measured T1 relaxation times between macromolecule and metabolite resonances in the brain spectrum to acquire ‘metabolite‐nulled’ macromolecule spectra. These spectra appear identical to the spectra of macromolecules isolated in vitro.
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Cited by
Sanacora, G., Mason, G. F., Rothman, D. L., Behar, K. L., Hyder, F., Petroff, O. A. C., Berman, R. M., Charney, D. S., & Krystal, J. H. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.11.1043 · Cited by 627
Self-citationDetermination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13 C NMR
Shen, J., Petersen, K. F., Behar, K. L., Brown, P., Nixon, T. W., Mason, G. F., Petroff, O. A. C., Shulman, G. I., Shulman, R. G., & Rothman, D. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.8235 · Cited by 462
Self-citationMao, X. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1519 · Cited by 296
The effect of gabapentin on brain gamma‐aminobutyric acid in patients with epilepsy
Petroff, O. A. C., Rothman, D. L., Behar, K. L., Lamoureux, D., & Mattson, R. H. (1996) · Annals of Neurology · doi:10.1002/ana.410390114 · Cited by 285
Self-citationN-acetylcysteine Boosts Brain and Blood Glutathione in Gaucher and Parkinson Diseases
Holmay, M. J., Terpstra, M., Coles, L. D., Mishra, U., Ahlskog, M., Öz, G., Cloyd, J. C., & Tuite, P. J. (2013) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e31829ae713 · Cited by 216
“680 seconds).(24) Metabolites quantified with Cramér-Rao lower bounds (estimated error of the metabolite quantification) greater than 50% or correlation coefficient less than −0.”
Method
Metadata
- Authors
- Behar, K. L., Rothman, D. L., Spencer, D. D., & Petroff, O. A. C.
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 1994-09
- Volume
- 32
- Issue
- 3
- Pages
- 294-302
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W2158388157
- Cited by
- 467
- References
- 0
- FWCI
- 11.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- Behar, K. L., Rothman, D. L., Spencer, D. D., & Petroff, O. A. C. (1994). Analysis of macromolecule resonances in 1H NMR spectra of human brain. Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.1910320304
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