The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Assessment of relative brain iron concentrations using T2‐weighted and T2*‐weighted MRI at 3 Tesla
Abstract
In this paper a new method is presented for the relative assessment of brain iron concentrations based on the evaluation of T 2 and T 2* ‐weighted images. A multiecho sequence is employed for rapid measurement of T 2 and T 2*, enabling calculation of the line broadening effect ( T 2′). Several groups have failed to show a correlation between T 2 and brain iron content. However, quantification of T 2′, and the associated relaxation rate R 2′, may provide a more specific relative measure of brain iron concentration. This may find application in the study of brain diseases, which cause associated changes in brain iron levels. A new method of field inhomogeneity correction is presented that allows the separation of global and local field inhomogeneities, leading to more accurate T 2* measurements and hence, T 2′ values. The combination of T 2*, and T 2‐weighted MRI methods enables the differentiation of Parlkinson's disease patients from normal age‐matched controls based on differences in iron content within the substantia nigra.
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Cites
Prudnikov, A. P., Brychkov, Y. A., Marichev, O. I., & Romer, R. H. (1988) · American Journal of Physics · doi:10.1119/1.15375 · Cited by 2,910
Dexter, D. T., Wells, F. R., Lee, A. J., Agid, F., Agid, Y., Jenner, P., & Marsden, C. D. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb07264.x · Cited by 1,149
Cited by
Neural responses during anticipation of a primary taste reward
O'Doherty, J. P., Deichmann, R., Critchley, H. D., & Dolan, R. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00603-7 · Cited by 1,076
Imaging iron stores in the brain using magnetic resonance imaging
Haacke, E. M., Cheng, N. Y. C., House, M. J., Liu, Q., Neelavalli, J., Ogg, R. J., Khan, A., Ayaz, M., Kirsch, W., & Obenaus, A. (2005) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2004.10.001 · Cited by 995
Quantitative susceptibility mapping (QSM): Decoding MRI data for a tissue magnetic biomarker
Wang, Y., & Liu, T. (2015) · Magnetic Resonance in Medicine · doi:10.1002/mrm.25358 · Cited by 878
Optimized EPI for fMRI studies of the orbitofrontal cortex
Deichmann, R., Gottfried, J. A., Hutton, C., & Turner, R. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00073-9 · Cited by 821
Myelin and iron concentration in the human brain: a quantitative study of MRI contrast
Stüber, C., Morawski, M., Schäfer, A., Labadie, C., Wähnert, M., Leuze, C., Streicher, M., Barapatre, N., Reimann, K., Geyer, S., et al. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.02.026 · Cited by 635
Metadata
- Authors
- Ordidge, R. J., Gorell, J. M., Deniau, J. C., Knight, R. A., & Helpern, J. A.
- Venue
- Magnetic Resonance in Medicine
- Publisher
- Wiley
- Published
- 1994-09
- Volume
- 32
- Issue
- 3
- Pages
- 335-341
- ISSN
- 0740-3194 (ISSN-L)
- 1522-2594
- OpenAlex
- W1983432533
- Cited by
- 323
- References
- 2
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ordidge, R. J., Gorell, J. M., Deniau, J. C., Knight, R. A., & Helpern, J. A. (1994). Assessment of relative brain iron concentrations using T2‐weighted and T2*‐weighted MRI at 3 Tesla. Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.1910320309
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