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Saturation recovery single‐shot acquisition (SASHA) for myocardial T1 mapping

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Chow, Kelvin, Flewitt, Jacqueline A., Green, Jordin D., Pagano, Joseph J., Friedrich, Matthias G., Thompson, Richard B.·2014·Magnetic Resonance in Medicine

Abstract

Purpose: To validate a new saturation recovery single‐shot acquisition (SASHA) pulse sequence for T1 mapping and to compare SASHA T1 values in heart failure patients and healthy controls. Theory: The SASHA sequence consists of 10 electrocardiogram‐triggered single‐shot balanced steady‐state free precession images in a breath‐hold. The first image is acquired without magnetization preparation and the remaining nine images follow saturation pulses with variable saturation recovery times. Methods: SASHA was validated through Bloch equation simulations, Monte Carlo simulations, and phantom experiments. Pre‐ and postcontrast myocardial and blood T1 values were measured in 29 healthy volunteers and 7 patients with heart failure. Results: SASHA T1 values had excellent agreement (bias, 5 ± 5 ms) with spin echo experiments in phantoms with a wide range of physiologic T1 and T2 values and its accuracy was independent of flip angle, absolute T1, T2, and heart rate. The average baseline myocardial T1 in heart failure patients was higher than in healthy controls (1200 ± 32 vs. 1170 ± 9 ms, P < 0.05) at 1.5T, as was the calculated blood–tissue partition coefficient, λ, (0.42 ± 0.04 vs. 0.38 ± 0.02, P < 0.05), consistent with diffuse myocardial fibrosis. Conclusions: The SASHA sequence is a simple and fast approach to in vivo T1 mapping with good accuracy in simulations and phantom experiments. Magn Reson Med 71:2082–2095, 2014. © 2013 Wiley Periodicals, Inc.

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Metadata

Authors
Chow, K., Flewitt, J. A., Green, J. D., Pagano, J. J., Friedrich, M. G., & Thompson, R. B.
Venue
Magnetic Resonance in Medicine
Publisher
Wiley
Published
2013-07-23
Volume
71
Issue
6
Pages
2082-2095
ISSN
  • 0740-3194 (ISSN-L)
  • 1522-2594
OpenAlex
W2149392970
Cited by
396
References
32
FWCI
24.01
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Saturation recovery single‐shot acquisition (SASHA) for myocardial T1 mapping. https://app.cochat.ai/papers/10.1002/mrm.24878
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Chow, K., Flewitt, J. A., Green, J. D., Pagano, J. J., Friedrich, M. G., & Thompson, R. B. (2014). Saturation recovery single‐shot acquisition (SASHA) for myocardial T1 mapping. Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.24878

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