Cited by 406Advanced Image Processing TechniquesAdvanced MRI Techniques and ApplicationsArtificial Intelligence in Healthcare and Education

Super‐resolution musculoskeletal MRI using deep learning

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Chaudhari, Akshay S., Fang, Zhongnan, Kogan, Feliks, Wood, Jeff, Stevens, Kathryn J., Gibbons, Eric K., Lee, Jin Hyung, Gold, Garry E. +1 more·2018·Magnetic Resonance in Medicine

Abstract

PURPOSE: To develop a super-resolution technique using convolutional neural networks for generating thin-slice knee MR images from thicker input slices, and compare this method with alternative through-plane interpolation methods. METHODS: We implemented a 3D convolutional neural network entitled DeepResolve to learn residual-based transformations between high-resolution thin-slice images and lower-resolution thick-slice images at the same center locations. DeepResolve was trained using 124 double echo in steady-state (DESS) data sets with 0.7-mm slice thickness and tested on 17 patients. Ground-truth images were compared with DeepResolve, clinically used tricubic interpolation, and Fourier interpolation methods, along with state-of-the-art single-image sparse-coding super-resolution. Comparisons were performed using structural similarity, peak SNR, and RMS error image quality metrics for a multitude of thin-slice downsampling factors. Two musculoskeletal radiologists ranked the 3 data sets and reviewed the diagnostic quality of the DeepResolve, tricubic interpolation, and ground-truth images for sharpness, contrast, artifacts, SNR, and overall diagnostic quality. Mann-Whitney U tests evaluated differences among the quantitative image metrics, reader scores, and rankings. Cohen's Kappa (κ) evaluated interreader reliability. RESULTS: DeepResolve had significantly better structural similarity, peak SNR, and RMS error than tricubic interpolation, Fourier interpolation, and sparse-coding super-resolution for all downsampling factors (p < .05, except 4 × and 8 × sparse-coding super-resolution downsampling factors). In the reader study, DeepResolve significantly outperformed (p < .01) tricubic interpolation in all image quality categories and overall image ranking. Both readers had substantial scoring agreement (κ = 0.73). CONCLUSION: DeepResolve was capable of resolving high-resolution thin-slice knee MRI from lower-resolution thicker slices, achieving superior quantitative and qualitative diagnostic performance to both conventionally used and state-of-the-art methods.

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  • Deep learning approaches have been introduced for MRI super-resolution.

    “Recently deep learning approaches has been introduced, e.g. generating super-resolution single (no reference information) and multi-contrast (applying a high-resolution image of another modality as reference) brain MR images using CNNs [197]; constructing superresolution brain MRI by a CNN stacked by multi-scale fusion units [198]; and super-resolution musculoskeletal MRI ('DeepResolve') [199].”

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  1. [7]Kijowski R Davis KW Woods MA Lindstrom MJ De Smet AA Gold GE Busse RF Knee joint: comprehensive assessment with 3D isotropic resolution fast spin-echo MR imaging–diagnostic performance compared with that of conventional MR imaging at 3.0 T Radiology 2009 252 486 495 10.1148/radiol.2523090028 19703886 PMC6939958 · DOI
  2. [20]Plenge E Poot DHJ Bernsen M Kotek G Houston G Wielopolski P van der Weerd L Niessen WJ Meijering E Super-resolution methods in MRI: Can they improve the trade-off between resolution, signal-to-noise ratio, and acquisition time? Magn Reson Med 2012 68 1983 1993 22298247

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Authors
Chaudhari, A. S., Fang, Z., Kogan, F., Wood, J., Stevens, K. J., Gibbons, E. K., Lee, J. H., Gold, G. E., & Hargreaves, B. A.
Affiliations
  • Stanford Medicine (US)
  • LVIS Corporation Palo Alto California
  • University of Utah (US)
  • Stanford University (US)
Corresponding author
Chaudhari, Akshay S.
Venue
Magnetic Resonance in Medicine
Publisher
Wiley
Published
2018-03-26
Volume
80
Issue
5
Pages
2139-2154
ISSN
  • 0740-3194 (ISSN-L)
  • 1522-2594
OpenAlex
W2794977498
Cited by
406
References
52
Citations by year
2026: 30 · 2025: 50 · 2024: 52 · 2023: 51 · 2022: 46 · 2021: 88 · 2020: 53 · 2019: 26 · 2018: 9
FWCI
22.01
Type
journal article
Language
en
Open access
Locations
  • Magnetic Resonance in Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (R01 AR063643, R01 EB002524, K24 AR062068, P41 EB015891, N01‐AR‐2‐2258, N01‐AR‐2‐2259, N01‐AR‐2‐2260, N01‐AR‐2‐2261, N01‐AR‐2‐2262)
  • GE Healthcare
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR062068, AR063643, AR22258, AR22259, AR22260, AR22261, AR22262)
  • National Institute of Biomedical Imaging and Bioengineering (EB002524, EB015891)
  • Thomas and Stacey Siebel Foundation
Topics
  • Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Advanced Image Processing Techniques
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
Keywords
MRI super-resolution, knee MRI, musculoskeletal MRI, convolutional neural networks, Fourier interpolation, image quality, reader study, inter-reader reliability
MeSH terms
Deep Learning, Algorithms, Cartilage Diseases, Humans, Knee, Magnetic Resonance Imaging, Pilot Projects, Phantoms, Imaging, Osteoarthritis, Knee, Imaging, Three-Dimensional, Signal-To-Noise Ratio

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